Privileged scaffolds in synthesis: 2, 5-piperazinediones as templates for the preparation of structurally diverse heterocycles JF González, I Ortín, E de la Cuesta, JC Menéndez Chemical Society Reviews 41 (21), 6902-6915, 2012 | 76 | 2012 |
Synthesis and cytotoxic activity of pyrazino [1, 2-b]-isoquinolines, 1-(3-isoquinolyl) isoquinolines, and 6, 15-iminoisoquino [3, 2-b]-3-benzazocines JF González, E de la Cuesta, C Avendaño Bioorganic & Medicinal Chemistry 15 (1), 112-118, 2007 | 55 | 2007 |
Synthesis and transport applications of 3-aminobicyclo [3, 2, 1] octane-3-carboxylic acids HN Christensen, ME Handlogten, JV Vadgama, E De la Cuesta, ... Journal of medicinal chemistry 26 (10), 1374-1378, 1983 | 55 | 1983 |
Synthesis of phthalascidin analogs JF González, L Salazar, E de la Cuesta, C Avendaño Tetrahedron 61 (31), 7447-7455, 2005 | 47 | 2005 |
Synthesis of diaza-anthraquinones by hetero Diels-Alder cycloaddition reactions C Gesto, E De la Cuesta, C Avendaño Tetrahedron 45 (14), 4477-4484, 1989 | 42 | 1989 |
Pyrazino [1, 2-b] isoquinolines: Synthesis and study of their cytostatic and cytotoxic properties I Ortín, JF González, E de la Cuesta, C Manguan-García, R Perona, ... Bioorganic & medicinal chemistry 16 (19), 9065-9078, 2008 | 38 | 2008 |
Pictet Spengler-type reactions in 3-arylmethylpiperazine-2, 5-diones. Synthesis of pyrazinotetrahydroisoquinolines JF González, E de la Cuesta, C Avendaño Tetrahedron 60 (30), 6319-6326, 2004 | 37 | 2004 |
A comparative study of synthetic approaches to 1-methyl-2, 5, 8 (1H)-quinolinetrione and 4-methyl-2, 5, 8 (1H)-quinolinetrione C Avendano, E De la Cuesta, C Gesto Synthesis 1991 (09), 727-730, 1991 | 33 | 1991 |
Improvements in aldol reactions with diketopiperazines JF Gonzalez, E de la Cuesta, C Avendano Synthetic communications 34 (9), 1589-1597, 2004 | 31 | 2004 |
Asymmetric Michael addition reactions using ethyl (S)-4, 4-dimethylpyroglutamate as a chiral auxiliary J Ezquerra, L Prieto, C Avendaño, JL Martos, E de la Cuesta Tetrahedron letters 40 (8), 1575-1578, 1999 | 31 | 1999 |
Synthesis and biological activity of new 1, 8-diaza-2, 9, 10-anthracenetrione derivatives C Gesto, E de la Cuesta, C Avendaño, F Emling Journal of pharmaceutical sciences 81 (8), 815-816, 1992 | 29 | 1992 |
Diels-Alder reactions of phosphaalkene and phosphadiene complexes H Trauner, E de la Cuesta, A Marinetti, F Mathey Bulletin de la Société chimique de France 4 (132), 384-393, 1995 | 28 | 1995 |
Metallation of 2 (1H)-Quinolinone: Synthesis of 3-Substituted Compounds M Fernandez, E De la Cuesta, C Avendaño Synthesis 1995 (11), 1362-1364, 1995 | 26 | 1995 |
Recent Synthetic Approaches to 6,15‐Iminoisoquino[3,2‐b]3‐benzazocine Compounds C Avendaño, E de la Cuesta Chemistry–A European Journal 16 (32), 9722-9734, 2010 | 25 | 2010 |
Short stereocontrolled synthesis of trans and cis-tetrahydro-pyrazinoisoquinolinediones JF González, E de la Cuesta, C Avendaño Tetrahedron letters 44 (23), 4395-4398, 2003 | 25 | 2003 |
Electrophilic substitution in 3-and 4-methyl-2 (1h) quinolinone through metallated species O Martin, E de la Cuesta, C Avendaño Tetrahedron 51 (27), 7547-7554, 1995 | 23 | 1995 |
Ring contraction of 1, 2, 4-triazepino [2, 3-a] benzimidazol-4-ones. New fused. beta.-lactams C Romano, E De la Cuesta, C Avendano The Journal of Organic Chemistry 56 (1), 74-78, 1991 | 23 | 1991 |
Base-catalyzed electrophilic substitution in 2 (1H)-quinolinones R Gonzalez, MT Ramos, E de la Cuesta, C Avendaño Heterocycles 36 (2), 315-322, 1993 | 22 | 1993 |
Acid-promoted reactions in 1-hydroxy, 1-dimethylaminomethyl and 1-methylene-4-arylmethyl-2, 4-dihydro-1H-pyrazino [2, 1-b] quinazoline-3, 6-diones ML Heredia, E de la Cuesta, C Avendaño Tetrahedron 58 (31), 6163-6170, 2002 | 21 | 2002 |
Synthesis of a novel tetrahydroisoquinoline pentacyclic framework I Ortin, JF González, E de la Cuesta, C Avendano Tetrahedron 65 (11), 2201-2211, 2009 | 19 | 2009 |