| Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory … H Chu, JFW Chan, TTT Yuen, H Shuai, S Yuan, Y Wang, B Hu, CCY Yip, ... The Lancet Microbe 1 (1), e14-e23, 2020 | 895 | 2020 |
| Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19 H Chu, JFW Chan, Y Wang, TTT Yuen, Y Chai, Y Hou, H Shuai, D Yang, ... Clinical Infectious Diseases 71 (6), 1400-1409, 2020 | 766 | 2020 |
| Attenuated replication and pathogenicity of SARS-CoV-2 B. 1.1. 529 Omicron H Shuai, JFW Chan, B Hu, Y Chai, TTT Yuen, F Yin, X Huang, C Yoon, ... Nature 603 (7902), 693-699, 2022 | 610 | 2022 |
| Attenuated interferon and proinflammatory response in SARS-CoV-2–infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation D Yang, H Chu, Y Hou, Y Chai, H Shuai, ACY Lee, X Zhang, Y Wang, ... The Journal of infectious diseases 222 (5), 734-745, 2020 | 206 | 2020 |
| Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells H Chu, CM Chan, X Zhang, Y Wang, S Yuan, J Zhou, RKH Au-Yeung, ... Journal of Biological Chemistry 293 (30), 11709-11726, 2018 | 193 | 2018 |
| Emerging SARS-CoV-2 variants expand species tropism to murines H Shuai, JFW Chan, TTT Yuen, C Yoon, JC Hu, L Wen, B Hu, D Yang, ... EBioMedicine 73, 2021 | 152 | 2021 |
| Host and viral determinants for efficient SARS-CoV-2 infection of the human lung H Chu, B Hu, X Huang, Y Chai, D Zhou, Y Wang, H Shuai, D Yang, Y Hou, ... Nature communications 12 (1), 134, 2021 | 149 | 2021 |
| An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron BX Quan, H Shuai, AJ Xia, Y Hou, R Zeng, XL Liu, GF Lin, JX Qiao, WP Li, ... Nature Microbiology 7 (5), 716-725, 2022 | 83 | 2022 |
| Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity H Chu, H Shuai, Y Hou, X Zhang, L Wen, X Huang, B Hu, D Yang, ... Science advances 7 (25), eabf8577, 2021 | 82 | 2021 |
| Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA. 1 and BA. 2 B Hu, JFW Chan, H Liu, Y Liu, Y Chai, J Shi, H Shuai, Y Hou, X Huang, ... Emerging Microbes & Infections 11 (1), 2275-2287, 2022 | 73 | 2022 |
| Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation X Zhang, H Chu, L Wen, H Shuai, D Yang, Y Wang, Y Hou, Z Zhu, S Yuan, ... Emerging microbes & infections 9 (1), 733-746, 2020 | 65 | 2020 |
| Coronaviruses exploit a host cysteine-aspartic protease for replication H Chu, Y Hou, D Yang, L Wen, H Shuai, C Yoon, J Shi, Y Chai, TTT Yuen, ... Nature 609 (7928), 785-792, 2022 | 60 | 2022 |
| Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target C Li, H Chu, X Liu, MC Chiu, X Zhao, D Wang, Y Wei, Y Hou, H Shuai, ... Emerging Microbes & Infections 9 (1), 2663-2672, 2020 | 55 | 2020 |
| Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer H Shuai, H Chu, Y Hou, D Yang, Y Wang, B Hu, X Huang, X Zhang, ... Journal of Infection 81 (4), e1-e10, 2020 | 53 | 2020 |
| SARS-CoV-2 induces a more robust innate immune response and replicates less efficiently than SARS-CoV in the human intestines: an ex vivo study with implications on … H Chu, JFW Chan, Y Wang, TTT Yuen, Y Chai, H Shuai, D Yang, B Hu, ... Cellular and molecular gastroenterology and hepatology 11 (3), 771-781, 2021 | 52 | 2021 |
| A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants C Huang, H Shuai, J Qiao, Y Hou, R Zeng, A Xia, L Xie, Z Fang, Y Li, ... Signal Transduction and Targeted Therapy 8 (1), 128, 2023 | 51 | 2023 |
| Bacillus Calmette-Guérin–induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice BZ Zhang, H Shuai, HR Gong, JC Hu, B Yan, TTT Yuen, YF Hu, C Yoon, ... JCI insight 7 (11), 2022 | 51 | 2022 |
| Virological features and pathogenicity of SARS-CoV-2 Omicron BA. 2 JFW Chan, B Hu, Y Chai, H Shuai, H Liu, J Shi, Y Liu, C Yoon, J Zhang, ... Cell Reports Medicine 3 (9), 2022 | 36 | 2022 |
| The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA. 1, BA. 2, and BA. 5 H Shuai, JFW Chan, B Hu, Y Chai, C Yoon, H Liu, Y Liu, J Shi, T Zhu, ... EBioMedicine 95, 2023 | 34 | 2023 |
| A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo JFW Chan, YJ Oh, S Yuan, H Chu, ML Yeung, D Canena, CCS Chan, ... Cell Reports Medicine 3 (10), 2022 | 32 | 2022 |
