Παρακολούθηση
Chon Lok Lei
Chon Lok Lei
University of Macau
Η διεύθυνση ηλεκτρονικού ταχυδρομείου έχει επαληθευτεί στον τομέα um.edu.mo - Αρχική σελίδα
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Calibration of ionic and cellular cardiac electrophysiology models
DG Whittaker, M Clerx, CL Lei, DJ Christini, GR Mirams
Wiley Interdisciplinary Reviews: Systems Biology and Medicine 12 (4), e1482, 2020
1092020
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer
CL Lei, A Fabbri, DG Whittaker, M Clerx, MJ Windley, AP Hill, GR Mirams, ...
Wellcome Open Research 5, 152, 2021
106*2021
Probabilistic inference on noisy time series (PINTS)
M Clerx, M Robinson, B Lambert, CL Lei, S Ghosh, GR Mirams, ...
arXiv preprint arXiv:1812.07388, 2018
652018
Considering discrepancy when calibrating a mechanistic electrophysiology model
CL Lei, S Ghosh, DG Whittaker, Y Aboelkassem, KA Beattie, CD Cantwell, ...
Philosophical Transactions of the Royal Society A 378 (2173), 20190349, 2020
622020
Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments
CL Lei, M Clerx, DG Whittaker, DJ Gavaghan, TP de Boer, GR Mirams
Philosophical Transactions of the Royal Society A 378 (2173), 20190348, 2020
582020
Rapid characterization of hERG channel kinetics I: using an automated high-throughput system
CL Lei, M Clerx, DJ Gavaghan, L Polonchuk, GR Mirams, K Wang
Biophysical Journal 117 (12), 2438-2454, 2019
542019
Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations
CL Lei, JA Kellard, M Hara, JD Johnson, B Rodriguez, LJB Briant
Islets 10 (4), 151-167, 2018
542018
Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology
CL Lei, K Wang, M Clerx, RH Johnstone, MP Hortigon-Vinagre, V Zamora, ...
Frontiers in physiology 8, 986, 2017
512017
Rapid characterization of hERG channel kinetics II: temperature dependence
CL Lei, M Clerx, KA Beattie, D Melgari, JC Hancox, DJ Gavaghan, ...
Biophysical Journal 117 (12), 2455-2470, 2019
502019
An audit of uncertainty in multi-scale cardiac electrophysiology models
RH Clayton, Y Aboelkassem, CD Cantwell, C Corrado, T Delhaas, ...
Philosophical Transactions of the Royal Society A 378 (2173), 20190335, 2020
482020
3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients
IM Lei, C Jiang, CL Lei, SR de Rijk, YC Tam, C Swords, MPF Sutcliffe, ...
Nature Communications 12 (1), 6260, 2021
472021
A hackable, multi-functional, and modular extrusion 3D printer for soft materials
IM Lei, Y Sheng, CL Lei, C Leow, YYS Huang
Scientific Reports 12 (1), 12294, 2022
252022
A Bayesian nonparametric method for detecting rapid changes in disease transmission
R Creswell, M Robinson, D Gavaghan, KV Parag, CL Lei, B Lambert
Journal of Theoretical Biology 558, 111351, 2023
132023
Neural network differential equations for ion channel modelling
CL Lei, GR Mirams
Frontiers in Physiology 12, 708944, 2021
132021
Autocorrelated measurement processes and inference for ordinary differential equation models of biological systems
B Lambert, CL Lei, M Robinson, M Clerx, R Creswell, S Ghosh, S Tavener, ...
Journal of the Royal Society Interface 20 (199), 20220725, 2023
122023
Learning transmission dynamics modelling of COVID-19 using comomodels
SA van der Vegt, L Dai, I Bouros, HJ Farm, R Creswell, O Dimdore-Miles, ...
Mathematical Biosciences 349, 108824, 2022
122022
Empirical quantification of predictive uncertainty due to model discrepancy by training with an ensemble of experimental designs: an application to ion channel kinetics
JG Shuttleworth, CL Lei, DG Whittaker, MJ Windley, AP Hill, SP Preston, ...
Bulletin of Mathematical Biology 86 (1), 2, 2024
102024
Model-driven optimal experimental design for calibrating cardiac electrophysiology models
CL Lei, M Clerx, DJ Gavaghan, GR Mirams
Computer Methods and Programs in Biomedicine 240, 107690, 2023
92023
Understanding the impact of numerical solvers on inference for differential equation models
R Creswell, KM Shepherd, B Lambert, GR Mirams, CL Lei, S Tavener, ...
Journal of the Royal Society Interface 21 (212), 20230369, 2024
72024
Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings
AP Clark, M Clerx, S Wei, CL Lei, TP de Boer, GR Mirams, DJ Christini, ...
Europace 25 (9), euad243, 2023
72023
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