Παρακολούθηση
Grace Q. Gong
Grace Q. Gong
Investigator Scientist
Η διεύθυνση ηλεκτρονικού ταχυδρομείου έχει επαληθευτεί στον τομέα mrc-lmb.cam.ac.uk
Τίτλος
Παρατίθεται από
Παρατίθεται από
Έτος
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
GQ Gong, B Bilanges, B Allsop, GR Masson, V Roberton, T Askwith, ...
Nature 618 (7963), 159-168, 2023
502023
Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
R Basnet, GQ Gong, C Li, MW Wang
Acta Pharmaceutica Sinica B 8 (5), 767-771, 2018
422018
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion
SD Heitz, DJ Hamelin, RM Hoffmann, N Greenberg, G Salloum, Z Erami, ...
Journal of Biological Chemistry 294 (12), 4621-4633, 2019
152019
Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds
GQ Gong, K Wang, XC Dai, Y Zhou, R Basnet, Y Chen, DH Yang, WJ Lee, ...
Acta Pharmacologica Sinica 39 (12), 1902-1912, 2018
152018
High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds
J Wang, GQ Gong, Y Zhou, WJ Lee, CM Buchanan, WA Denny, ...
Acta Pharmacologica Sinica 39 (11), 1816-1822, 2018
132018
Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists
L Lin, G Lin, Q Zhou, RAD Bathgate, GQ Gong, D Yang, Q Liu, MW Wang
Bioorganic Chemistry 110, 104782, 2021
92021
Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity
GQ Gong, JD Kendall, JMJ Dickson, GW Rewcastle, CM Buchanan, ...
Biochemical Journal 474 (13), 2261-2276, 2017
82017
Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function
MM Swamynathan, S Kuang, KE Watrud, MR Doherty, C Gineste, ...
Science 386 (6720), eadk9167, 2024
52024
Precision Targeting of Mutant PI3Kα
GQ Gong, B Vanhaesebroeck
Cancer Discovery 14 (2), 204-207, 2024
22024
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding
GQ Gong, GR Masson, WJJ Lee, JMJ Dickson, JD Kendall, ...
Biochemical Journal, 2024
12024
Making PI3K superfamily enzymes run faster
GQ Gong, M Anandapadamanaban, MS Islam, IM Hay, M Bourguet, ...
Advances in Biological Regulation, 101060, 2024
2024
Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
GQ Gong
PhD Thesis-University of Auckland, 2017
2017
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