A small-molecule PI3Kα activator for cardioprotection and neuroregeneration GQ Gong, B Bilanges, B Allsop, GR Masson, V Roberton, T Askwith, ... Nature 618 (7963), 159-168, 2023 | 50 | 2023 |
Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention R Basnet, GQ Gong, C Li, MW Wang Acta Pharmaceutica Sinica B 8 (5), 767-771, 2018 | 42 | 2018 |
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion SD Heitz, DJ Hamelin, RM Hoffmann, N Greenberg, G Salloum, Z Erami, ... Journal of Biological Chemistry 294 (12), 4621-4633, 2019 | 15 | 2019 |
Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds GQ Gong, K Wang, XC Dai, Y Zhou, R Basnet, Y Chen, DH Yang, WJ Lee, ... Acta Pharmacologica Sinica 39 (12), 1902-1912, 2018 | 15 | 2018 |
High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds J Wang, GQ Gong, Y Zhou, WJ Lee, CM Buchanan, WA Denny, ... Acta Pharmacologica Sinica 39 (11), 1816-1822, 2018 | 13 | 2018 |
Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists L Lin, G Lin, Q Zhou, RAD Bathgate, GQ Gong, D Yang, Q Liu, MW Wang Bioorganic Chemistry 110, 104782, 2021 | 9 | 2021 |
Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity GQ Gong, JD Kendall, JMJ Dickson, GW Rewcastle, CM Buchanan, ... Biochemical Journal 474 (13), 2261-2276, 2017 | 8 | 2017 |
Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function MM Swamynathan, S Kuang, KE Watrud, MR Doherty, C Gineste, ... Science 386 (6720), eadk9167, 2024 | 5 | 2024 |
Precision Targeting of Mutant PI3Kα GQ Gong, B Vanhaesebroeck Cancer Discovery 14 (2), 204-207, 2024 | 2 | 2024 |
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding GQ Gong, GR Masson, WJJ Lee, JMJ Dickson, JD Kendall, ... Biochemical Journal, 2024 | 1 | 2024 |
Making PI3K superfamily enzymes run faster GQ Gong, M Anandapadamanaban, MS Islam, IM Hay, M Bourguet, ... Advances in Biological Regulation, 101060, 2024 | | 2024 |
Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome GQ Gong PhD Thesis-University of Auckland, 2017 | | 2017 |