De novo design of protein structure and function with RFdiffusion JL Watson, D Juergens, NR Bennett, BL Trippe, J Yim, HE Eisenach, ... Nature 620 (7976), 1089-1100, 2023 | 1158* | 2023 |
Scaffolding protein functional sites using deep learning J Wang, S Lisanza, D Juergens, D Tischer, JL Watson, KM Castro, ... Science 377 (6604), 387-394, 2022 | 374* | 2022 |
Design of biologically active binary protein 2D materials AJ Ben-Sasson, JL Watson, W Sheffler, MC Johnson, A Bittleston, ... Nature 589 (7842), 468-473, 2021 | 130 | 2021 |
De novo design of high-affinity binders of bioactive helical peptides S Vázquez Torres, PJY Leung, P Venkatesh, ID Lutz, F Hink, HH Huynh, ... Nature 626 (7998), 435-442, 2024 | 102* | 2024 |
Macromolecular condensation buffers intracellular water potential JL Watson, E Seinkmane, CT Styles, A Mihut, LK Krüger, KE McNally, ... Nature 623 (7988), 842-852, 2023 | 64 | 2023 |
Atomically accurate de novo design of single-domain antibodies NR Bennett, JL Watson, RJ Ragotte, AJ Borst, DL See, C Weidle, ... biorxiv, 2024 | 58 | 2024 |
Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology A Stangherlin, JL Watson, DCS Wong, S Barbiero, A Zeng, E Seinkmane, ... Nature communications 12 (1), 6035, 2021 | 50 | 2021 |
Zero‐shot mutation effect prediction on protein stability and function using RoseTTAFold S Mansoor, M Baek, D Juergens, JL Watson, D Baker Protein Science 32 (11), e4780, 2023 | 34* | 2023 |
High-efficacy subcellular micropatterning of proteins using fibrinogen anchors JL Watson, S Aich, B Oller-Salvia, AA Drabek, SC Blacklow, J Chin, ... Journal of Cell Biology 220 (2), e202009063, 2021 | 22 | 2021 |
Protein stability buffers the cost of translation attenuation following eIF2α phosphorylation K Schneider, GM Nelson, JL Watson, J Morf, M Dalglish, LM Luh, A Weber, ... Cell reports 32 (11), 2020 | 21 | 2020 |
De novo design of pH-responsive self-assembling helical protein filaments H Shen, EM Lynch, S Akkineni, JL Watson, J Decarreau, NP Bethel, ... Nature Nanotechnology 19 (7), 1016-1021, 2024 | 19 | 2024 |
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells JL Watson, LK Krüger, AJ Ben-Sasson, A Bittleston, MN Shahbazi, ... Cell 186 (21), 4710-4727. e35, 2023 | 17 | 2023 |
Multiple-instance-learning-based detection of coeliac disease in histological whole-slide images J Denholm, BA Schreiber, SC Evans, OM Crook, A Sharma, JL Watson, ... Journal of Pathology Informatics 13, 100151, 2022 | 11 | 2022 |
Diffusing protein binders to intrinsically disordered proteins C Liu, K Wu, H Choi, H Han, X Zhang, JL Watson, S Shijo, AK Bera, ... biorxiv, 2024 | 8 | 2024 |
HEATR5B associates with dynein‐dynactin and promotes motility of AP1‐bound endosomal membranes V Madan, L Albacete‐Albacete, L Jin, P Scaturro, JL Watson, N Muschalik, ... The EMBO Journal 42 (23), e114473, 2023 | 7 | 2023 |
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, ... BioRxiv, 2023.03. 22.533832, 2023 | 3 | 2023 |
Improved protein binder design using beta-pairing targeted RFdiffusion I Sappington, M Toul, DS Lee, SA Robinson, I Goreshnik, C McCurdy, ... bioRxiv, 2024.10. 11.617496, 2024 | 2 | 2024 |
Quantitative Chemical Delivery of Quantum Dots into the Cytosol of Cells JL Watson, A Stangherlin, E Derivery Quantum Dots: Applications in Biology, 179-197, 2020 | 2 | 2020 |
A role for vessel‐associated extracellular matrix proteins in multiple sclerosis pathology M Pisa, JL Watson, JI Spencer, G Niblett, Y Mahjoub, A Lockhart, ... Brain Pathology 34 (6), e13263, 2024 | 1 | 2024 |
Parametrically guided design of beta barrels and transmembrane nanopores using deep learning DE Kim, JL Watson, D Juergens, S Majumder, SR Gerben, A Kang, ... BioRxiv, 2024 | 1 | 2024 |