| The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response J Zhou, CY Liu, SH Back, RL Clark, D Peisach, Z Xu, RJ Kaufman Proceedings of the national academy of sciences 103 (39), 14343-14348, 2006 | 463 | 2006 |
| Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action Y Yan, Q Liu, X Zang, S Yuan, U Bat-Erdene, C Nguyen, J Gan, J Zhou, ... Nature 559 (7714), 415-418, 2018 | 243 | 2018 |
| Stereodivergent protein engineering of a lipase to access all possible stereoisomers of chiral esters with two stereocenters J Xu, Y Cen, W Singh, J Fan, L Wu, X Lin, J Zhou, M Huang, MT Reetz, ... Journal of the American Chemical Society 141 (19), 7934-7945, 2019 | 144 | 2019 |
| Catalytic asymmetric reduction of difficult-to-reduce ketones: triple-code saturation mutagenesis of an alcohol dehydrogenase Z Sun, R Lonsdale, A Ilie, G Li, J Zhou, MT Reetz ACS Catalysis 6 (3), 1598-1605, 2016 | 131 | 2016 |
| Structure-guided triple-code saturation mutagenesis: efficient tuning of the stereoselectivity of an epoxide hydrolase Z Sun, R Lonsdale, L Wu, G Li, A Li, J Wang, J Zhou, MT Reetz ACS catalysis 6 (3), 1590-1597, 2016 | 128 | 2016 |
| Reshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolution Z Sun, R Lonsdale, XD Kong, JH Xu, J Zhou, MT Reetz Angewandte Chemie 127 (42), 12587-12592, 2015 | 124 | 2015 |
| Structural basis of Vta1 function in the multivesicular body sorting pathway J Xiao, H Xia, J Zhou, IF Azmi, BA Davies, DJ Katzmann, Z Xu Developmental cell 14 (1), 37-49, 2008 | 117 | 2008 |
| Structural insight into enantioselective inversion of an alcohol dehydrogenase reveals a “polar gate” in stereorecognition of diaryl ketones J Zhou, Y Wang, G Xu, L Wu, R Han, U Schwaneberg, Y Rao, YL Zhao, ... Journal of the American Chemical Society 140 (39), 12645-12654, 2018 | 113 | 2018 |
| Regio‐and stereoselective steroid hydroxylation at C7 by cytochrome P450 monooxygenase mutants A Li, CG Acevedo‐Rocha, L D'Amore, J Chen, Y Peng, M Garcia‐Borràs, ... Angewandte Chemie 132 (30), 12599-12605, 2020 | 110 | 2020 |
| Structural determinants of SecB recognition by SecA in bacterial protein translocation J Zhou, Z Xu Nature Structural & Molecular Biology 10 (11), 942-947, 2003 | 104 | 2003 |
| Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates XD Kong, S Yuan, L Li, S Chen, JH Xu, J Zhou Proceedings of the National Academy of Sciences 111 (44), 15717-15722, 2014 | 97 | 2014 |
| Molecular basis of prodrug activation by human valacyclovirase, an α-amino acid ester hydrolase L Lai, Z Xu, J Zhou, KD Lee, GL Amidon Journal of Biological Chemistry 283 (14), 9318-9327, 2008 | 96 | 2008 |
| Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution Y Cen, W Singh, M Arkin, TS Moody, M Huang, J Zhou, Q Wu, MT Reetz Nature communications 10 (1), 3198, 2019 | 89 | 2019 |
| Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition X Huang, J Feng, J Cui, G Jiang, W Harrison, X Zang, J Zhou, B Wang, ... Nature Catalysis 5 (7), 586-593, 2022 | 85 | 2022 |
| Structural basis of nonribosomal peptide macrocyclization in fungi J Zhang, N Liu, RA Cacho, Z Gong, Z Liu, W Qin, C Tang, Y Tang, J Zhou Nature chemical biology 12 (12), 1001-1003, 2016 | 79 | 2016 |
| Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII C Zheng, H Liu, S Yuan, J Zhou, B Zhang Blood, The Journal of the American Society of Hematology 116 (25), 5698-5706, 2010 | 78 | 2010 |
| Splicing proofreading at 5′ splice sites by ATPase Prp28p F Yang, XY Wang, ZM Zhang, J Pu, YJ Fan, J Zhou, CC Query, YZ Xu Nucleic acids research 41 (8), 4660-4670, 2013 | 70 | 2013 |
| Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding H Zhu, G Xu, K Zhang, X Kong, R Han, J Zhou, Y Ni Scientific reports 6 (1), 27779, 2016 | 66 | 2016 |
| Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4 J Xiao, H Xia, K Yoshino-Koh, J Zhou, Z Xu Journal of molecular biology 374 (3), 655-670, 2007 | 64 | 2007 |
| Surface initiated polymerization from substrates of low initiator density and its applications in biosensors H Ma, J He, X Liu, J Gan, G Jin, J Zhou ACS applied materials & interfaces 2 (11), 3223-3230, 2010 | 61 | 2010 |
