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Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease PK Auluck, HYE Chan, JQ Trojanowski, VMY Lee, NM Bonini Science 295 (5556), 865-868, 2002 | 1628 | 2002 |
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS AC Elden, HJ Kim, MP Hart, AS Chen-Plotkin, BS Johnson, X Fang, ... Nature 466 (7310), 1069-1075, 2010 | 1470 | 2010 |
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70 JM Warrick, HY Chan, GL Gray-Board, Y Chai, HL Paulson, NM Bonini Nature genetics 23 (4), 425-428, 1999 | 1077 | 1999 |
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila JM Warrick, HL Paulson, GL Gray-Board, QT Bui, KH Fischbeck, ... Cell 93 (6), 939-949, 1998 | 838 | 1998 |
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila S Gunawardena, LS Her, RG Brusch, RA Laymon, IR Niesman, ... Neuron 40 (1), 25-40, 2003 | 789 | 2003 |
The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye NM Bonini, WM Leiserson, S Benzer Cell 72 (3), 379-395, 1993 | 630 | 1993 |
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease Y Chai, SL Koppenhafer, NM Bonini, HL Paulson Journal of Neuroscience 19 (23), 10338-10347, 1999 | 568 | 1999 |
Drosophila as a Model for Human Neurodegenerative Disease J Bilen, NM Bonini Annu. Rev. Genet. 39 (1), 153-171, 2005 | 556 | 2005 |
Spinocerebellar ataxia 3 and Machado‐Joseph disease: clinical, molecular, and neuropathological features A Durr, G Stevanin, G Cancel, C Duyckaerts, N Abbas, O Didierjean, ... Annals of neurology 39 (4), 490-499, 1996 | 546 | 1996 |
Reward learning in normal and mutant Drosophila BL Tempel, N Bonini, DR Dawson, WG Quinn Proceedings of the National Academy of Sciences 80 (5), 1482-1486, 1983 | 483 | 1983 |
A yeast functional screen predicts new candidate ALS disease genes J Couthouis, MP Hart, J Shorter, M DeJesus-Hernandez, R Erion, ... Proceedings of the National Academy of Sciences 108 (52), 20881-20890, 2011 | 462 | 2011 |
The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila N Liu, M Landreh, K Cao, M Abe, GJ Hendriks, JR Kennerdell, Y Zhu, ... Nature 482 (7386), 519-523, 2012 | 454 | 2012 |
Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models HJ Kim, AR Raphael, ES LaDow, L McGurk, RA Weber, JQ Trojanowski, ... Nature genetics 46 (2), 152-160, 2014 | 434 | 2014 |
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson’s disease M Meulener, AJ Whitworth, CE Armstrong-Gold, P Rizzu, P Heutink, ... Current Biology 15 (17), 1572-1577, 2005 | 430 | 2005 |
Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila HYE Chan, JM Warrick, GL Gray-Board, HL Paulson, NM Bonini Human molecular genetics 9 (19), 2811-2820, 2000 | 418 | 2000 |
Poly (ADP-ribose) prevents pathological phase separation of TDP-43 by promoting liquid demixing and stress granule localization L McGurk, E Gomes, L Guo, J Mojsilovic-Petrovic, V Tran, RG Kalb, ... Molecular cell 71 (5), 703-717. e9, 2018 | 399 | 2018 |
Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation MK Perez, HL Paulson, SJ Pendse, SJ Saionz, NM Bonini, RN Pittman The Journal of cell biology 143 (6), 1457-1470, 1998 | 397 | 1998 |
Drosophila as an In Vivo Model for Human Neurodegenerative Disease L McGurk, A Berson, NM Bonini Genetics 201 (2), 377-402, 2015 | 384 | 2015 |
RNA toxicity is a component of ataxin-3 degeneration in Drosophila LB Li, Z Yu, X Teng, NM Bonini Nature 453 (7198), 1107-1111, 2008 | 372 | 2008 |