| Recent developments in fragment-based drug discovery M Congreve, G Chessari, D Tisi, AJ Woodhead Journal of medicinal chemistry 51 (13), 3661-3680, 2008 | 751 | 2008 |
| Diverse, high-quality test set for the validation of protein− ligand docking performance MJ Hartshorn, ML Verdonk, G Chessari, SC Brewerton, WTM Mooij, ... Journal of medicinal chemistry 50 (4), 726-741, 2007 | 705 | 2007 |
| Modeling water molecules in protein− ligand docking using GOLD ML Verdonk, G Chessari, JC Cole, MJ Hartshorn, CW Murray, ... Journal of medicinal chemistry 48 (20), 6504-6515, 2005 | 490 | 2005 |
| Discovery of (2, 4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1, 3-dihydroisoindol-2-yl] methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone … AJ Woodhead, H Angove, MG Carr, G Chessari, M Congreve, JE Coyle, ... Journal of medicinal chemistry 53 (16), 5956-5969, 2010 | 316 | 2010 |
| Cancer drug design and discovery S Neidle Elsevier, 2011 | 312 | 2011 |
| From fragment to clinical candidate—a historical perspective G Chessari, AJ Woodhead Drug discovery today 14 (13-14), 668-675, 2009 | 274 | 2009 |
| Application of fragment-based lead generation to the discovery of novel, cyclic amidine β-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency PD Edwards, JS Albert, M Sylvester, D Aharony, D Andisik, O Callaghan, ... Journal of medicinal chemistry 50 (24), 5912-5925, 2007 | 263 | 2007 |
| Trisubstituted acridine derivatives as potent and selective telomerase inhibitors RJ Harrison, J Cuesta, G Chessari, MA Read, SK Basra, AP Reszka, ... Journal of medicinal chemistry 46 (21), 4463-4476, 2003 | 260 | 2003 |
| Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency CW Murray, MG Carr, O Callaghan, G Chessari, M Congreve, S Cowan, ... Journal of medicinal chemistry 53 (16), 5942-5955, 2010 | 231 | 2010 |
| Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors N Howard, C Abell, W Blakemore, G Chessari, M Congreve, S Howard, ... Journal of medicinal chemistry 49 (4), 1346-1355, 2006 | 208 | 2006 |
| Structure-based drug discovery SS Bhat, V Niranjan, SA Bandikatte, S Govindappa, A Vishal Molecular Modeling and Docking Techniques for Drug Discovery and Design, 435-472, 2025 | 186 | 2025 |
| Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of β-secretase M Congreve, D Aharony, J Albert, O Callaghan, J Campbell, RAE Carr, ... Journal of medicinal chemistry 50 (6), 1124-1132, 2007 | 183 | 2007 |
| Application of fragment screening by X-ray crystallography to β-secretase CW Murray, O Callaghan, G Chessari, A Cleasby, M Congreve, ... Journal of medicinal chemistry 50 (6), 1116-1123, 2007 | 172 | 2007 |
| Computational approaches in supramolecular chemistry G Wipff Springer Science & Business Media, 2012 | 131* | 2012 |
| Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function SM Saalau-Bethell, AJ Woodhead, G Chessari, MG Carr, J Coyle, ... Nature chemical biology 8 (11), 920-925, 2012 | 126 | 2012 |
| Quantitative determination of intermolecular interactions with fluorinated aromatic rings H Adams, JL Jimenez Blanco, G Chessari, CA Hunter, CMR Low, ... Chemistry–A European Journal 7 (16), 3494-3503, 2001 | 120 | 2001 |
| Fragment-based drug discovery targeting inhibitor of apoptosis proteins: discovery of a non-alanine lead series with dual activity against cIAP1 and XIAP G Chessari, IM Buck, JEH Day, PJ Day, A Iqbal, CN Johnson, EJ Lewis, ... Journal of medicinal chemistry 58 (16), 6574-6588, 2015 | 103 | 2015 |
| An evaluation of force‐field treatments of aromatic interactions G Chessari, CA Hunter, CMR Low, MJ Packer, JG Vinter, C Zonta Chemistry–A European Journal 8 (13), 2860-2867, 2002 | 95 | 2002 |
| Discovery of a potent nonpeptidomimetic, small-molecule antagonist of cellular inhibitor of apoptosis protein 1 (cIAP1) and X-linked inhibitor of apoptosis protein (XIAP) E Tamanini, IM Buck, G Chessari, E Chiarparin, JEH Day, M Frederickson, ... Journal of Medicinal Chemistry 60 (11), 4611-4625, 2017 | 77 | 2017 |
| ASTX660, a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP, potently induces TNFα-dependent apoptosis in cancer cell lines and inhibits tumor growth GA Ward, EJ Lewis, JS Ahn, CN Johnson, JF Lyons, V Martins, JM Munck, ... Molecular cancer therapeutics 17 (7), 1381-1391, 2018 | 72 | 2018 |
