Παρακολούθηση
Jianjun Cheng (程建军)
Jianjun Cheng (程建军)
Η διεύθυνση ηλεκτρονικού ταχυδρομείου έχει επαληθευτεί στον τομέα shanghaitech.edu.cn
Τίτλος
Παρατίθεται από
Παρατίθεται από
Έτος
G protein-coupled receptors: structure-and function-based drug discovery
D Yang, Q Zhou, V Labroska, S Qin, S Darbalaei, Y Wu, E Yuliantie, L Xie, ...
Signal transduction and targeted therapy 6 (1), 7, 2021
5222021
5-HT2C receptor structures reveal the structural basis of GPCR polypharmacology
Y Peng, JD McCorvy, K Harpsøe, K Lansu, S Yuan, P Popov, L Qu, M Pu, ...
Cell 172 (4), 719-730. e14, 2018
2542018
Structure-based discovery of nonhallucinogenic psychedelic analogs
D Cao, J Yu, H Wang, Z Luo, X Liu, L He, J Qi, L Fan, L Tang, Z Chen, J Li, ...
Science 375 (6579), 403-411, 2022
2242022
Biased ligands of G protein-coupled receptors (GPCRs): Structure–functional selectivity relationships (SFSRs) and therapeutic potential
L Tan, W Yan, JD McCorvy, J Cheng
Journal of medicinal chemistry 61 (22), 9841-9878, 2018
1282018
Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
L Fan, L Tan, Z Chen, J Qi, F Nie, Z Luo, J Cheng, S Wang
Nature communications 11 (1), 1074, 2020
972020
Structural basis for strychnine activation of human bitter taste receptor TAS2R46
W Xu, L Wu, S Liu, X Liu, X Cao, C Zhou, J Zhang, Y Fu, Y Guo, Y Wu, ...
Science 377 (6612), 1298-1304, 2022
792022
Momilactone and related diterpenoids as potential agricultural chemicals
M Zhao, J Cheng, B Guo, J Duan, CT Che
Journal of Agricultural and Food Chemistry 66 (30), 7859-7872, 2018
572018
5-HT2C agonists modulate schizophrenia-like behaviors in mice
VM Pogorelov, RM Rodriguiz, J Cheng, M Huang, CM Schmerberg, ...
Neuropsychopharmacology 42 (11), 2163-2177, 2017
532017
Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties
Z Chen, L Fan, H Wang, J Yu, D Lu, J Qi, F Nie, Z Luo, Z Liu, J Cheng, ...
Nature Neuroscience 25 (1), 39-49, 2022
482022
Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents
J Cheng, PM Giguère, OK Onajole, W Lv, A Gaisin, H Gunosewoyo, ...
Journal of medicinal chemistry 58 (4), 1992-2002, 2015
442015
Enantioselective Total Synthesis of (−)-(S)-Stepholidine
JJ Cheng, YS Yang
The Journal of Organic Chemistry 74 (23), 9225-9228, 2009
412009
Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral …
D Kong, T Xue, B Guo, J Cheng, S Liu, J Wei, Z Lu, H Liu, G Gong, T Lan, ...
Journal of Medicinal Chemistry 62 (6), 3088-3106, 2019
382019
Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists
J Cheng, JD McCorvy, PM Giguere, H Zhu, T Kenakin, BL Roth, ...
Journal of medicinal chemistry 59 (21), 9866-9880, 2016
362016
Design, synthesis, and structure–activity relationship studies of conformationally restricted mutilin 14-carbamates
L Fu, X Liu, C Ling, J Cheng, X Guo, H He, S Ding, Y Yang
Bioorganic & medicinal chemistry letters 22 (2), 814-819, 2012
362012
Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand
Y Guo, H Zhang, X Chen, W Cai, J Cheng, Y Yang, G Jin, X Zhen
Schizophrenia research 115 (1), 41-49, 2009
362009
Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants
W Duan, D Cao, S Wang, J Cheng
Chemical Reviews 124 (1), 124-163, 2023
322023
Enhancing the signaling of GPCRs via orthosteric ions
HCS Chan, Y Xu, L Tan, H Vogel, J Cheng, D Wu, S Yuan
ACS Central Science 6 (2), 274-282, 2020
322020
Tumor Immunotherapy Using A2A Adenosine Receptor Antagonists
J Zhang, W Yan, W Duan, K Wüthrich, J Cheng
Pharmaceuticals 13 (9), 237, 2020
302020
Further advances in optimizing (2-phenylcyclopropyl) methylamines as novel serotonin 2C agonists: effects on hyperlocomotion, prepulse inhibition, and cognition models
J Cheng, PM Giguere, CM Schmerberg, VM Pogorelov, RM Rodriguiz, ...
Journal of medicinal chemistry 59 (2), 578-591, 2016
302016
Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic …
G Zhang, J Cheng, JD McCorvy, PJ Lorello, BJ Caldarone, BL Roth, ...
Journal of medicinal chemistry 60 (14), 6273-6288, 2017
262017
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