Παρακολούθηση
henk-jan guchelaar
henk-jan guchelaar
Leiden University Medical center
Η διεύθυνση ηλεκτρονικού ταχυδρομείου έχει επαληθευτεί στον τομέα lumc.nl - Αρχική σελίδα
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Genetics of rheumatoid arthritis contributes to biology and drug discovery
Y Okada, D Wu, G Trynka, T Raj, C Terao, K Ikari, Y Kochi, K Ohmura, ...
Nature 506 (7488), 376-381, 2014
26382014
Pharmacogenetics: from bench to byte—an update of guidelines
JJ Swen, M Nijenhuis, A de Boer, L Grandia, AH Maitland‐van der Zee, ...
Clinical Pharmacology & Therapeutics 89 (5), 662-673, 2011
12722011
Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions
A Vermes, HJ Guchelaar, J Dankert
Journal of Antimicrobial Chemotherapy 46 (2), 171-179, 2000
9542000
The risk of cancer in users of statins
MR Graaf, AB Beiderbeck, ACG Egberts, DJ Richel, HJ Guchelaar
Journal of clinical oncology 22 (12), 2388-2394, 2004
6352004
Cardiotoxicity of cytotoxic drugs
KJM Schimmel, DJ Richel, RBA Van den Brink, HJ Guchelaar
Cancer treatment reviews 30 (2), 181-191, 2004
5702004
Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and …
KE Caudle, K Sangkuhl, M Whirl‐Carrillo, JJ Swen, CE Haidar, TE Klein, ...
Clinical and translational science 13 (1), 116-124, 2020
4872020
Clinical pharmacokinetics of tyrosine kinase inhibitors
NP van Erp, H Gelderblom, HJ Guchelaar
Cancer treatment reviews 35 (8), 692-706, 2009
4842009
Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis
JAM Wessels, TWJ Huizinga, HJ Guchelaar
Rheumatology 47 (3), 249-255, 2008
4382008
DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis
LM Henricks, CATC Lunenburg, FM de Man, D Meulendijks, ...
The Lancet Oncology 19 (11), 1459-1467, 2018
4192018
Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer
MR Graaf, DJ Richel, CJF van Noorden, HJ Guchelaar
Cancer treatment reviews 30 (7), 609-641, 2004
3802004
Making sense of big data in health research: towards an EU action plan
C Auffray, R Balling, I Barroso, L Bencze, M Benson, J Bergeron, ...
Genome medicine 8, 1-13, 2016
3582016
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy
MP Goetz, K Sangkuhl, HJ Guchelaar, M Schwab, M Province, ...
Clinical Pharmacology & Therapeutics 103 (5), 770-777, 2018
3352018
Liposomal drug formulations in cancer therapy: 15 years along the road
M Slingerland, HJ Guchelaar, H Gelderblom
Drug discovery today 17 (3-4), 160-166, 2012
3272012
A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study
JJ Swen, CH van der Wouden, LEN Manson, H Abdullah-Koolmees, ...
The Lancet 401 (10374), 347-356, 2023
3232023
Implementing pharmacogenomics in Europe: design and implementation strategy of the ubiquitous pharmacogenomics consortium
CH van der Wouden, A Cambon‐Thomsen, E Cecchin, KC Cheung, ...
Clinical Pharmacology & Therapeutics 101 (3), 341-358, 2017
3212017
Pharmacogenetics: from bench to byte
JJ Swen, I Wilting, AL De Goede, L Grandia, H Mulder, DJ Touw, ...
Clinical pharmacology & therapeutics 83 (5), 781-787, 2008
3052008
A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent‐onset rheumatoid arthritis
JAM Wessels, SM van der Kooij, S le Cessie, W Kievit, P Barerra, ...
Arthritis & Rheumatism 56 (6), 1765-1775, 2007
3052007
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single‐nucleotide polymorphisms in genes coding for folate pathway enzymes
JAM Wessels, JK de Vries‐Bouwstra, BT Heijmans, PE Slagboom, ...
Arthritis & Rheumatism 54 (4), 1087-1095, 2006
3032006
Relationship between Single Nucleotide Polymorphisms and Haplotypes in DPYD and Toxicity and Efficacy of Capecitabine in Advanced Colorectal Cancer
MJ Deenen, J Tol, AM Burylo, VD Doodeman, A De Boer, A Vincent, ...
Clinical Cancer Research 17 (10), 3455-3468, 2011
2682011
Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment
HJ Guchelaar, A Vermes, JH Meerwaldt
Supportive care in cancer 5, 281-288, 1997
2581997
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