| Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions K Han, EE Jeng, GT Hess, DW Morgens, A Li, MC Bassik Nature biotechnology 35 (5), 463-474, 2017 | 546 | 2017 |
| Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells GT Hess, L Frésard, K Han, CH Lee, A Li, KA Cimprich, SB Montgomery, ... Nature methods 13 (12), 1036-1042, 2016 | 539 | 2016 |
| Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens DW Morgens, M Wainberg, EA Boyle, O Ursu, CL Araya, CK Tsui, ... Nature communications 8 (1), 15178, 2017 | 386 | 2017 |
| Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade JM Hyman, AJ Firestone, VM Heine, Y Zhao, CA Ocasio, K Han, M Sun, ... Proceedings of the National Academy of Sciences 106 (33), 14132-14137, 2009 | 366 | 2009 |
| CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities K Han, SE Pierce, A Li, K Spees, GR Anderson, JA Seoane, YH Lo, ... Nature 580 (7801), 136-141, 2020 | 268 | 2020 |
| A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies DK Breslow, S Hoogendoorn, AR Kopp, DW Morgens, BK Vu, ... Nature genetics 50 (3), 460-471, 2018 | 178 | 2018 |
| KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics B Milic, A Chakraborty, K Han, MC Bassik, SM Block Proceedings of the National Academy of Sciences 115 (20), E4613-E4622, 2018 | 61 | 2018 |
| Parallel measurement of dynamic changes in translation rates in single cells K Han, A Jaimovich, G Dey, D Ruggero, O Meyuhas, N Sonenberg, ... Nature methods 11 (1), 86-93, 2014 | 49 | 2014 |
| The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling T Cupido, PG Rack, AJ Firestone, JM Hyman, K Han, S Sinha, CA Ocasio, ... Angewandte Chemie 121 (13), 2357-2360, 2009 | 47 | 2009 |
| E2A-PBX1 remodels oncogenic signaling networks in B-cell precursor acute lymphoid leukemia J Duque-Afonso, CH Lin, K Han, MC Wei, J Feng, JH Kurzer, ... Cancer research 76 (23), 6937-6949, 2016 | 39 | 2016 |
| Combined proteomic and genetic interaction mapping reveals new RAS effector pathways and susceptibilities MR Kelly, K Kostyrko, K Han, NA Mooney, EE Jeng, K Spees, PT Dinh, ... Cancer discovery 10 (12), 1950-1967, 2020 | 37 | 2020 |
| The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity L Gan, A Seki, K Shen, H Iyer, K Han, A Hayer, R Wollman, X Ge, JR Lin, ... Nature cell biology 21 (5), 614-626, 2019 | 37 | 2019 |
| The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity M Yoshinaga, K Han, DW Morgens, T Horii, R Kobayashi, T Tsuruyama, ... Nature Communications 13 (1), 6435, 2022 | 25 | 2022 |
| Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins DW Morgens, C Chan, AJ Kane, NR Weir, A Li, MM Dubreuil, CK Tsui, ... Elife 8, e48434, 2019 | 23 | 2019 |
| Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens. Nat Commun 8, 15178 DW Morgens, M Wainberg, EA Boyle, O Ursu, CL Araya, CK Tsui, ... | 22 | 2017 |
| Gene fusions create partner and collateral dependencies essential to cancer cell survival R Gillani, BKA Seong, J Crowdis, JR Conway, NV Dharia, S Alimohamed, ... Cancer research 81 (15), 3971-3984, 2021 | 18 | 2021 |
| CBP Modulates Sensitivity to Dasatinib in Pre-BCR+ Acute Lymphoblastic Leukemia J Duque-Afonso, CH Lin, K Han, DW Morgens, EE Jeng, Z Weng, J Jeong, ... Cancer research 78 (22), 6497-6508, 2018 | 12 | 2018 |
| Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia PK Grüninger, F Uhl, H Herzog, G Gentile, M Andrade-Martinez, ... Cancer Gene Therapy 29 (11), 1751-1760, 2022 | 11 | 2022 |
| Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens. Nat Commun. 2017; 8: 15178 DW Morgens, M Wainberg, EA Boyle, O Ursu, CL Araya, CK Tsui, ... Epub 2017/05/06. https://doi. org/10.1038/ncomms15178 PMID: 28474669, 0 | 11 | |
| Development of combination therapies with BTK inhibitors and dasatinib to treat CNS-infiltrating E2A-PBX1+/preBCR+ ALL G Gentile, T Poggio, A Catalano, M Voutilainen, M Lahnalampi, ... Blood Advances 8 (11), 2846-2860, 2024 | 2 | 2024 |
