Identification of a cellularly active SIRT6 allosteric activator Z Huang, J Zhao, W Deng, Y Chen, J Shang, K Song, L Zhang, C Wang, ... Nature chemical biology 14 (12), 1118-1126, 2018 | 249 | 2018 |
Immunotherapy for Alzheimer’s disease: Targeting β-amyloid and beyond C Song, J Shi, P Zhang, Y Zhang, J Xu, L Zhao, R Zhang, H Wang, ... Translational neurodegeneration 11 (1), 18, 2022 | 187 | 2022 |
Combating COVID-19 with integrated traditional Chinese and Western medicine in China L Ni, L Chen, X Huang, C Han, J Xu, H Zhang, X Luan, Y Zhao, J Xu, ... Acta Pharmaceutica Sinica B 10 (7), 1149-1162, 2020 | 170 | 2020 |
A redox mechanism underlying nucleolar stress sensing by nucleophosmin K Yang, M Wang, Y Zhao, X Sun, Y Yang, X Li, A Zhou, H Chu, H Zhou, ... Nature communications 7 (1), 13599, 2016 | 150 | 2016 |
α-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation Y Wang, Z Xia, JR Xu, YX Wang, LN Hou, Y Qiu, HZ Chen Neuropharmacology 62 (2), 871-881, 2012 | 145 | 2012 |
Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3 T Zhang, J Li, F Yin, B Lin, Z Wang, J Xu, H Wang, D Zuo, G Wang, Y Hua, ... Oncogene 36 (47), 6627-6639, 2017 | 111 | 2017 |
Biomimetic ApoE-reconstituted high density lipoprotein nanocarrier for blood–brain barrier penetration and amyloid beta-targeting drug delivery Q Song, H Song, J Xu, J Huang, M Hu, X Gu, J Chen, G Zheng, H Chen, ... Molecular Pharmaceutics 13 (11), 3976-3987, 2016 | 111 | 2016 |
AlloFinder: a strategy for allosteric modulator discovery and allosterome analyses M Huang, K Song, X Liu, S Lu, Q Shen, R Wang, J Gao, Y Hong, Q Li, ... Nucleic Acids Research 46 (W1), W451-W458, 2018 | 89 | 2018 |
Selective eradication of tumor vascular pericytes by peptide-conjugated nanoparticles for antiangiogenic therapy of melanoma lung metastasis YY Guan, X Luan, JR Xu, YR Liu, Q Lu, C Wang, HJ Liu, YG Gao, ... Biomaterials 35 (9), 3060-3070, 2014 | 76 | 2014 |
Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human colorectal tumor by inhibiting VEGFR2 signaling YY Guan, HJ Liu, X Luan, JR Xu, Q Lu, YR Liu, YG Gao, M Zhao, HZ Chen, ... Phytomedicine 22 (1), 103-110, 2015 | 71 | 2015 |
Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling L Tao, W Ma, L Wu, M Xu, Y Yang, W Zhang, W Sha, H Li, J Xu, R Feng, ... Gut 68 (12), 2214-2227, 2019 | 52 | 2019 |
Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells Q Zhang, Y Chen, D Ni, Z Huang, J Wei, L Feng, JC Su, Y Wei, S Ning, ... Acta Pharmaceutica Sinica B 12 (2), 876-889, 2022 | 47 | 2022 |
Platycodin D inhibits tumor growth by antiangiogenic activity via blocking VEGFR2-mediated signaling pathway X Luan, YG Gao, YY Guan, JR Xu, Q Lu, M Zhao, YR Liu, HJ Liu, C Fang, ... Toxicology and applied pharmacology 281 (1), 118-124, 2014 | 47 | 2014 |
Sesquiterpene Quinones/Hydroquinones from the Marine Sponge Spongia pertusa Esper J Li, BB Gu, F Sun, JR Xu, WH Jiao, HB Yu, BN Han, F Yang, XC Zhang, ... Journal of Natural Products 80 (5), 1436-1445, 2017 | 45 | 2017 |
Targeted inhibition of KCa3. 1 channel attenuates airway inflammation and remodeling in allergic asthma ZH Yu, JR Xu, YX Wang, GN Xu, ZP Xu, K Yang, DZ Wu, YY Cui, HZ Chen American journal of respiratory cell and molecular biology 48 (6), 685-693, 2013 | 42 | 2013 |
Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis L Zhang, J Xiao, J Xu, T Fu, Z Cao, L Zhu, HZ Chen, X Shen, H Jiang, ... Cell research 26 (12), 1330-1344, 2016 | 39 | 2016 |
A graphene oxide coated tapered microfiber acting as a super-sensor for rapid detection of SARS-CoV-2 H Jia, A Zhang, Y Yang, Y Cui, J Xu, H Jiang, S Tao, D Zhang, H Zeng, ... Lab on a Chip 21 (12), 2398-2406, 2021 | 37 | 2021 |
Synthesis and activity evaluation of tilorone analogs as potential anticancer agents D Zhou, W Tuo, H Hu, J Xu, H Chen, Z Rao, Y Xiao, X Hu, P Liu European Journal of Medicinal Chemistry 64, 432-441, 2013 | 37 | 2013 |
M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP‐PKA and PI3K‐Akt LX Zhao, YH Ge, JB Li, CH Xiong, PY Law, JR Xu, Y Qiu, HZ Chen The FASEB Journal 33 (5), 6622-6631, 2019 | 34 | 2019 |
Anti-biofilm activities of coumarin as quorum sensing inhibitor for Porphyromonas gingivalis Z He, W Jiang, Y Jiang, J Dong, Z Song, J Xu, W Zhou Journal of oral microbiology 14 (1), 2055523, 2022 | 33 | 2022 |