Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer WB Parker Chemical reviews 109 (7), 2880-2893, 2009 | 750 | 2009 |
Metabolism and mechanism of action of 5-fluorouracil WB Parker, YC Cheng Pharmacology & therapeutics 48 (3), 381-395, 1990 | 607 | 1990 |
Metabolism and antiviral activity of ribavirin WB Parker Virus research 107 (2), 165-171, 2005 | 297 | 2005 |
Effects of 2-Chloro-9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)adenine on K562 Cellular Metabolism and the Inhibition of Human Ribonucleotide Reductase and … WB Parker, SC Shaddix, CH Chang, EL White, LM Rose, RW Brockman, ... Cancer research 51 (9), 2386-2394, 1991 | 273 | 1991 |
Failure of cAMP agonists to activate rescued ΔF508 CFTR in CFBE41o– airway epithelial monolayers Z Bebok, JF Collawn, J Wakefield, W Parker, Y Li, K Varga, EJ Sorscher, ... The Journal of physiology 569 (2), 601-615, 2005 | 247 | 2005 |
Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines. EJ Sorscher, S Peng, Z Bebok, PW Allan, LL Bennett Jr, WB Parker Gene therapy 1 (4), 233-238, 1994 | 229 | 1994 |
Interaction of 2-halogenated dATP analogs (F, Cl, and Br) with human DNA polymerases, DNA primase, and ribonucleotide reductase. WB Parker, AR Bapat, JX Shen, AJ Townsend, YC Cheng Molecular pharmacology 34 (4), 485-491, 1988 | 208 | 1988 |
Mitochondrial toxicity of antiviral nucleoside analogs WB Parker Journal of NIH Research 6, 57-57, 1994 | 181 | 1994 |
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3 … WB Parker, EL White, SC Shaddix, LJ Ross, RW Buckheit Jr, JM Germany, ... Journal of Biological Chemistry 266 (3), 1754-1762, 1991 | 176 | 1991 |
Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies JR Bertino, WR Waud, WB Parker, M Lubin Cancer biology & therapy 11 (7), 627-632, 2011 | 165 | 2011 |
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase WB Parker, SA King, PW Allan, LL Bennett Jr, JA Secrist III, ... Human gene therapy 8 (14), 1637-1644, 1997 | 146 | 1997 |
Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases EL White, WB Parker, LJ Macy, SC Shaddix, G McCaleb, JA Secrist III, ... Biochemical and biophysical research communications 161 (2), 393-398, 1989 | 130 | 1989 |
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells WB Parker, PW Allan, SC Shaddix, LM Rose, HF Speegle, GY Gillespie, ... Biochemical pharmacology 55 (10), 1673-1681, 1998 | 126 | 1998 |
Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase EM Bennett, C Li, PW Allan, WB Parker, SE Ealick Journal of Biological Chemistry 278 (47), 47110-47118, 2003 | 125 | 2003 |
Purine nucleoside antimetabolites in development for the treatment of cancer WB Parker, JA Secrist 3rd, WR Waud Current opinion in investigational drugs (London, England: 2000) 5 (6), 592-596, 2004 | 121 | 2004 |
Bystander Killing of Melanoma Cells Using the Human Tyrosinase Promoter to Express the Escherichia coli Purine Nucleoside Phosphorylase Gene BW Hughes, AH Wells, Z Bebok, VK Gadi, RI Garver Jr, WB Parker, ... Cancer research 55 (15), 3339-3345, 1995 | 117 | 1995 |
Anti-AIDS agents, 1. Isolation and characterization of four new tetragalloylquinic acids as a new class of HIV reverse transcriptase inhibitors from tannic acid M Nishizawa, T Yamagishi, GE Dutschman, WB Parker, AJ Bodner, ... Journal of natural products 52 (4), 762-768, 1989 | 116 | 1989 |
Lymphoma chemovirotherapy: CD20-targeted and convertase-armed measles virus can synergize with fludarabine G Ungerechts, C Springfeld, ME Frenzke, J Lampe, PB Johnston, ... Cancer research 67 (22), 10939-10947, 2007 | 106 | 2007 |
An immunocompetent murine model for oncolysis with an armed and targeted measles virus G Ungerechts, C Springfeld, ME Frenzke, J Lampe, WB Parker, ... Molecular Therapy 15 (11), 1991-1997, 2007 | 102 | 2007 |
Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl) adenine, and 2-chloro … WB Parker, SC Shaddix, LM Rose, DS Shewach, LW Hertel, JA Secrist, ... Molecular pharmacology 55 (3), 515-520, 1999 | 100 | 1999 |