Παρακολούθηση
David E. Place
David E. Place
Principal Investigator, Genentech
Η διεύθυνση ηλεκτρονικού ταχυδρομείου έχει επαληθευτεί στον τομέα gene.com
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ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways
T Kuriakose, SM Man, RK Subbarao Malireddi, R Karki, S Kesavardhana, ...
Science immunology 1 (2), aag2045-aag2045, 2016
6602016
Identification of the PANoptosome: a molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis)
S Christgen, M Zheng, S Kesavardhana, R Karki, RKS Malireddi, ...
Frontiers in cellular and infection microbiology 10, 237, 2020
3692020
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome
P Samir, S Kesavardhana, DM Patmore, S Gingras, RKS Malireddi, ...
Nature 573 (7775), 590-594, 2019
3622019
Recent advances in inflammasome biology
DE Place, TD Kanneganti
Current opinion in immunology 50, 32-38, 2018
3402018
IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes
SM Man, R Karki, M Sasai, DE Place, S Kesavardhana, J Temirov, ...
Cell 167 (2), 382-396. e17, 2016
3062016
Toward targeting inflammasomes: insights into their regulation and activation
S Christgen, DE Place, TD Kanneganti
Cell research 30 (4), 315-327, 2020
2442020
PANoptosis in microbial infection
DE Place, SJ Lee, TD Kanneganti
Current opinion in microbiology 59, 42-49, 2021
1802021
DNA sensing in the innate immune response
B Briard, DE Place, TD Kanneganti
Physiology, 2020
1782020
IRF8 regulates transcription of Naips for NLRC4 inflammasome activation
R Karki, D Place, P Samir, J Mavuluri, BR Sharma, A Balakrishnan, ...
Cell 173 (4), 920-933. e13, 2018
1762018
Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation
SM Man, DE Place, T Kuriakose, TD Kanneganti
Journal of Leucocyte Biology 101 (1), 143-150, 2017
1212017
Galactosaminogalactan activates the inflammasome to provide host protection
B Briard, T Fontaine, P Samir, DE Place, L Muszkieta, RKS Malireddi, ...
Nature 588 (7839), 688-692, 2020
1082020
Cell death–mediated cytokine release and its therapeutic implications
DE Place, TD Kanneganti
Journal of Experimental Medicine 216 (7), 1474-1486, 2019
822019
Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
DE Place, RKS Malireddi, J Kim, P Vogel, M Yamamoto, TD Kanneganti
Nature Communications 12 (1), 496, 2021
772021
Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection
B Briard, R Karki, RKS Malireddi, A Bhattacharya, DE Place, J Mavuluri, ...
Nature microbiology 4 (2), 316-327, 2019
722019
The innate immune system and cell death in autoinflammatory and autoimmune disease
DE Place, TD Kanneganti
Current opinion in immunology 67, 95-105, 2020
662020
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response
S Kesavardhana, P Samir, M Zheng, RKS Malireddi, R Karki, BR Sharma, ...
Journal of Biological Chemistry 296, 2021
452021
A dominant negative Cx43 mutant differentially affects tumorigenic and invasive properties in human metastatic melanoma cells
SN Zucker, TA Bancroft, DE Place, B Des Soye, A Bagati, R Berezney
Journal of cellular physiology 228 (4), 853-859, 2013
322013
Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection-or vaccination-induced immunity against Bordetella pertussis
X Zhang, SE Hester, MJ Kennett, AT Karanikas, L Bendor, DE Place, ...
Infection and immunity 79 (1), 527-541, 2011
252011
First‐in‐human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC‐2394, in healthy volunteers
F Tang, R Kunder, T Chu, A Hains, A Nguyen, JM McBride, Y Zhong, ...
Clinical and Translational Science 16 (9), 1653-1666, 2023
242023
ASK family kinases are required for optimal NLRP3 inflammasome priming
DE Place, P Samir, R Karki, B Briard, P Vogel, TD Kanneganti
The American Journal of Pathology 188 (4), 1021-1030, 2018
242018
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