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Ünal Metin Tokat
Ünal Metin Tokat
Medicana Health Group - Precision Oncology Center
Η διεύθυνση ηλεκτρονικού ταχυδρομείου έχει επαληθευτεί στον τομέα medicana.com.tr - Αρχική σελίδα
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Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
O Saatci, A Kaymak, U Raza, PG Ersan, O Akbulut, CE Banister, ...
Nature communications 11 (1), 2416, 2020
2722020
Reactivation of cAMP pathway by PDE4D inhibition represents a novel druggable axis for overcoming tamoxifen resistance in ER-positive breast cancer
RR Mishra, N Belder, SA Ansari, M Kayhan, H Bal, U Raza, PG Ersan, ...
Clinical Cancer Research 24 (8), 1987-2001, 2018
562018
Targeting HIF1-alpha/miR-326/ITGA5 axis potentiates chemotherapy response in triple-negative breast cancer
R Assidicky, UM Tokat, IO Tarman, O Saatci, PG Ersan, U Raza, H Ogul, ...
Breast cancer research and treatment 193 (2), 331-348, 2022
322022
TLR ligand loaded exosome mediated immunotherapy of established mammary Tumor in mice
M Yildirim, TC Yildirim, N Turay, T Bildik, B Ibibik, I Evcili, PG Ersan, ...
Immunology Letters 239, 32-41, 2021
272021
HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin
M Biondini, A Kiepas, L El-Houjeiri, MG Annis, BE Hsu, AM Fortier, ...
Oncogene 41 (12), 1701-1717, 2022
152022
Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer
O Saatci, R Alam, KT Huynh-Dam, A Isik, M Uner, N Belder, PG Ersan, ...
Cell Death & Disease 15 (6), 418, 2024
92024
PARP inhibitor combinations with high-dose vitamin C in the treatment of Ewing sarcoma: two case reports and mechanistic overview
A Adibi, ÜM Tokat, E Özgü, E Aydın, İ Demiray, M Demiray
Therapeutic Advances in Medical Oncology 15, 17588359231213841, 2023
62023
Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer. Nat Commun 11: 2416
O Saatci, A Kaymak, U Raza, PG Ersan, O Akbulut, CE Banister, ...
52020
Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer. Nat Commun. 2020; 11: 2416
O Saatci, A Kaymak, U Raza, PG Ersan, O Akbulut, CE Banister, ...
5
Exceptional response to MEK inhibition in a patient with RAF1-mutant myxofibrosarcoma: case report and mechanistic overview
E Özgü, E Aydin, A Adibi, ÜM Tokat, O Tutar, J Hu, I Demiray, R Kurzrock, ...
JCO Precision Oncology 7, e2300299, 2023
32023
Toxic PARP trapping upon cAMP-induced DNA damage reinstates the efficacy of endocrine therapy and CDK4/6 inhibitors in treatment-refractory ER+ breast cancer
O Saatci, M Cetin, M Uner, UM Tokat, I Chatzistamou, PG Ersan, ...
Nature Communications 14 (1), 6997, 2023
32023
Durable radiologic and molecular complete response following nivolumab in an HNSCC patient with UV signature and HIV
A Adibi, ÜM Tokat, E Özgü, N Mamyrov, E Aydın, ŞN Bilgiç, O Tutar, ...
Oral Oncology 154, 106859, 2024
12024
Evaluation of the Relationship between Aromatase/Sirtuin1 Interaction and miRNA Expression in Human Neuroblastoma Cells
Y Kartal, UM Tokat, P Kelicen-Ugur, S Yılmaz, S Karahan, MT Budak
Current molecular pharmacology 16 (6), 609-628, 2023
12023
Precision-Guided Durable Response From Venetoclax With Decitabine in a Patient With a Metastatic Refractory IDH2-Mutant Cholangiocarcinoma
E Özgü, ÜM Tokat, A Adibi, ŞN Bilgiç, E Aydın, O Tutar, M Demiray
JCO Precision Oncology 9, e2400652, 2025
2025
Case report: Near-complete response to neratinib-based treatment in HR-positive HER2-amplified metastatic breast cancer refractory to trastuzumab deruxtecan
ÜM Tokat, A Adibi, E Aydın, ŞN Bilgiç, E Özgü, O Tutar, M Demiray
Frontiers in Oncology 14, 1484750, 2025
2025
Elacestrant plus alpelisib in an ESR1 and PIK3CA co-mutated and heavily pretreated metastatic breast cancer: the first case report for combination efficacy and …
ÜM Tokat, ŞN Bilgiç, E Aydın, A Adibi, E Özgü, O Tutar, M Demiray
Therapeutic Advances in Medical Oncology 16, 17588359241297101, 2024
2024
Therapeutic vulnerabilities and pan-cancer landscape of BRAF class III mutations in epithelial solid tumors
E Özgü, BG Kaplan, S Sivakumar, ES Sokol, E Aydın, ÜM Tokat, A Adibi, ...
BJC reports 2 (1), 77, 2024
2024
Personalized Immunotherapy Achieves Complete Response in Metastatic Adenoid Cystic Carcinoma Despite Lack of Conventional Biomarkers
ÜM Tokat, A Adibi, E Aydın, E Özgü, ŞN Bilgiç, O Tutar, ...
Current Oncology 31 (10), 5838-5849, 2024
2024
Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response
W Wofford, J Kim, D Kim, AH Janneh, HG Lee, FC Atilgan, N Oleinik, ...
Cell reports 43 (8), 2024
2024
Case report: Precision guided reactive cancer management: molecular complete response in heavily pretreated metastatic CRC by dual immunotherapy and sorafenib
E Aydın, ÜM Tokat, A Adibi, E Özgü, ŞN Bilgiç, M Demiray
Frontiers in Oncology 14, 1405170, 2024
2024
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