Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back P Kharel, G Becker, V Tsvetkov, P Ivanov Nucleic acids research 48 (22), 12534-12555, 2020 | 144 | 2020 |
The role of RNA G‐quadruplexes in human diseases and therapeutic strategies P Kharel, S Balaratnam, N Beals, S Basu Wiley Interdisciplinary Reviews: RNA 11 (1), e1568, 2020 | 105 | 2020 |
eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function SM Lyons, P Kharel, Y Akiyama, S Ojha, D Dave, V Tsvetkov, W Merrick, ... Nucleic acids research 48 (11), 6223-6233, 2020 | 84 | 2020 |
Stress promotes RNA G-quadruplex folding in human cells P Kharel, M Fay, EV Manasova, PJ Anderson, AV Kurkin, JU Guo, ... Nature communications 14 (1), 205, 2023 | 71 | 2023 |
Isolation and initial structure-functional characterization of endogenous tRNA-derived stress-induced RNAs Y Akiyama, P Kharel, T Abe, P Anderson, P Ivanov RNA biology 17 (8), 1116-1124, 2020 | 59 | 2020 |
Tumor interferon signaling is regulated by a lncRNA INCR1 transcribed from the PD-L1 locus M Mineo, SM Lyons, M Zdioruk, N von Spreckelsen, R Ferrer-Luna, H Ito, ... Molecular cell 78 (6), 1207-1223. e8, 2020 | 59 | 2020 |
Targeting of G-quadruplex harboring pre-miRNA 92b by LNA rescues PTEN expression in NSCL cancer cells G Mirihana Arachchilage, P Kharel, J Reid, S Basu ACS chemical biology 13 (4), 909-914, 2018 | 38 | 2018 |
Evidence of extensive RNA oxidation in normal appearing cortex of multiple sclerosis brain P Kharel, J McDonough, S Basu Neurochemistry international 92, 43-48, 2016 | 19 | 2016 |
RNA G-quadruplexes and stress: emerging mechanisms and functions P Kharel, P Ivanov Trends in Cell Biology 34 (9), 771-784, 2024 | 15 | 2024 |
Mono-and bilayer smectic liquid crystal ordering in dense solutions of “gapped” DNA duplexes P Gyawali, R Saha, GP Smith, M Salamonczyk, P Kharel, S Basu, R Li, ... Proceedings of the National Academy of Sciences 118 (12), e2019996118, 2021 | 14 | 2021 |
Isolation, identification and antimicrobial activity of a Withanolide [WS-1] from the roots of Withania somnifera P Kharel, MD Manandhar, SK Kalauni, S Awale, J Baral Nepal Journal of Science and Technology 12, 179-186, 2011 | 13 | 2011 |
Volume measurements and fluorescent staining indicate an increase in permeability for organic cation transporter substrates during apoptosis BA Gibbons, P Kharel, LC Robinson, RA Synowicki, MA Model Experimental cell research 344 (1), 112-119, 2016 | 12 | 2016 |
Engineered domain swapping indicates context dependent functional role of RNA G-quadruplexes D Bhattacharyya, MJ Morris, P Kharel, GM Arachchilage, KM Fedeli, ... Biochimie 137, 147-150, 2017 | 9 | 2017 |
NAT8L mRNA oxidation is linked to neurodegeneration in multiple sclerosis P Kharel, NK Singhal, T Mahendran, N West, B Croos, J Rana, L Smith, ... Cell Chemical Biology 30 (3), 308-320. e5, 2023 | 5 | 2023 |
Structure and Functions of RNA G-quadruplexes P Kharel, P Ivanov RNA Structure and Function, 183-203, 2023 | 4 | 2023 |
Identification of bona fide RNA G-quadruplex binding proteins P Kharel, P Ivanov Methods in Enzymology 695, 255-274, 2024 | 3 | 2024 |
Rationally designed DNA therapeutics can modulate human TH expression by controlling specific GQ formation in its promoter N Beals, MM Farhath, P Kharel, B Croos, T Mahendran, J Johnson, ... Molecular Therapy 30 (2), 831-844, 2022 | 3 | 2022 |
Rationally designed DNA therapeutics can modulate human tyrosine hydroxylase expression by controlling specific G-quadruplex formation in its promoter N Beals, M M Farhath, P Kharel, B Croos, T Mahendran, J Johnson, ... Elsevier Ltd., 2021 | 3 | 2021 |
HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide E Deforzh, P Kharel, A Karelin, P Ivanov, AM Krichevsky bioRxiv, 2023 | 1 | 2023 |
Identification of oxidized mitochondrial mRNA in human neurons under oxidative stress J Rana, P Kharel, S Basu The FASEB Journal 33 (S1), 651.21-651.21, 2019 | 1 | 2019 |