| Overcoming mutation-based resistance to antiandrogens with rational drug design MD Balbas, MJ Evans, DJ Hosfield, J Wongvipat, VK Arora, PA Watson, ... elife 2, e00499, 2013 | 459 | 2013 |
| Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair BR Chapados, DJ Hosfield, S Han, J Qiu, B Yelent, B Shen, JA Tainer Cell 116 (1), 39-50, 2004 | 353 | 2004 |
| Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis DJ Hosfield, Y Guan, BJ Haas, RP Cunningham, JA Tainer Cell 98 (3), 397-408, 1999 | 339 | 1999 |
| Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3′ ends justify the means CD Mol, DJ Hosfield, JA Tainer Mutation Research/DNA Repair 460 (3-4), 211-229, 2000 | 334 | 2000 |
| Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis DJ Hosfield, Y Zhang, DR Dougan, A Broun, LW Tari, RV Swanson, J Finn Journal of Biological Chemistry 279 (10), 8526-8529, 2004 | 331 | 2004 |
| Structural Basis for Isozyme-specific Regulation of Electron Transfer in Nitric-oxide Synthase*[boxs] ED Garcin, CM Bruns, SJ Lloyd, DJ Hosfield, M Tiso, R Gachhui, ... Journal of biological chemistry 279 (36), 37918-37927, 2004 | 323 | 2004 |
| Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity DJ Hosfield, CD Mol, B Shen, JA Tainer Cell 95 (1), 135-146, 1998 | 317 | 1998 |
| Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans S Adak, AM Bilwes, K Panda, D Hosfield, KS Aulak, JF McDonald, ... Proceedings of the National Academy of Sciences 99 (1), 107-112, 2002 | 175 | 2002 |
| Envisioning the molecular choreography of DNA base excision repair SS Parikh, CD Mol, DJ Hosfield, JA Tainer Current opinion in structural biology 9 (1), 37-47, 1999 | 148 | 1999 |
| Kinase inhibitors Q Dong, DJ Hosfield, BR Paraselli, N Scorah, JA Stafford, MB Wallace, ... US Patent 7,713,973, 2010 | 140 | 2010 |
| Conformational flexibility in crystal structures of human 11β-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation DJ Hosfield, Y Wu, RJ Skene, M Hilgers, A Jennings, GP Snell, ... Journal of Biological Chemistry 280 (6), 4639-4648, 2005 | 126 | 2005 |
| A fully integrated protein crystallization platform for small-molecule drug discovery D Hosfield, J Palan, M Hilgers, D Scheibe, DE McRee, RC Stevens Journal of structural biology 142 (1), 207-217, 2003 | 126 | 2003 |
| DNA apurinic-apyrimidinic site binding and excision by endonuclease IV ED Garcin, DJ Hosfield, SA Desai, BJ Haas, M Björas, RP Cunningham, ... Nature structural & molecular biology 15 (5), 515-522, 2008 | 118 | 2008 |
| Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes SE Tsutakawa, DS Shin, CD Mol, T Izumi, AS Arvai, AK Mantha, ... Journal of Biological Chemistry 288 (12), 8445-8455, 2013 | 104 | 2013 |
| The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells SW Fanning, R Jeselsohn, V Dharmarajan, CG Mayne, M Karimi, ... Elife 7, e37161, 2018 | 101 | 2018 |
| Structural insights into the conformational selectivity of STI-571 and related kinase inhibitors. CD Mol, D Fabbro, DJ Hosfield Current opinion in drug discovery & development 7 (5), 639-648, 2004 | 94 | 2004 |
| Discovery of CC-90011: a potent and selective reversible inhibitor of lysine specific demethylase 1 (LSD1) T Kanouni, C Severin, RW Cho, NYY Yuen, J Xu, L Shi, C Lai, ... Journal of Medicinal Chemistry 63 (23), 14522-14529, 2020 | 93 | 2020 |
| Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication BR Chapados, Q Chai, DJ Hosfield, J Qiu, B Shen, JA Tainer Journal of Molecular Biology 307 (2), 541-556, 2001 | 90 | 2001 |
| Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1 DJ Hosfield, G Frank, Y Weng, JA Tainer, B Shen Journal of Biological Chemistry 273 (42), 27154-27161, 1998 | 90 | 1998 |
| Flap endonuclease homologs in archaebacteria exist as independent proteins B Shen, J Qiu, D Hosfield, JA Tainer Trends in biochemical sciences 23 (5), 171-173, 1998 | 85 | 1998 |
