| Protein sensors for membrane sterols JL Goldstein, RA DeBose-Boyd, MS Brown Cell 124 (1), 35-46, 2006 | 1968 | 2006 |
| Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR J Ou, H Tu, B Shan, A Luk, RA DeBose-Boyd, Y Bashmakov, JL Goldstein, ... Proceedings of the National Academy of Sciences 98 (11), 6027-6032, 2001 | 609 | 2001 |
| Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase RA DeBose-Boyd Cell research 18 (6), 609-621, 2008 | 494 | 2008 |
| Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain N Sever, T Yang, MS Brown, JL Goldstein, RA DeBose-Boyd Molecular cell 11 (1), 25-33, 2003 | 481 | 2003 |
| Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase BL Song, N Sever, RA DeBose-Boyd Molecular cell 19 (6), 829-840, 2005 | 437 | 2005 |
| Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi RA DeBose-Boyd, MS Brown, WP Li, A Nohturfft, JL Goldstein, ... Cell 99 (7), 703-712, 1999 | 395 | 1999 |
| Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol N Sever, BL Song, D Yabe, JL Goldstein, MS Brown, RA DeBose-Boyd Journal of Biological Chemistry 278 (52), 52479-52490, 2003 | 386 | 2003 |
| Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol BL Song, NB Javitt, RA DeBose-Boyd Cell metabolism 1 (3), 179-189, 2005 | 337 | 2005 |
| Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi A Nohturfft, RA DeBose-Boyd, S Scheek, JL Goldstein, MS Brown Proceedings of the National Academy of Sciences 96 (20), 11235-11240, 1999 | 308 | 1999 |
| Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands RA DeBose-Boyd, J Ou, JL Goldstein, MS Brown Proceedings of the National Academy of Sciences 98 (4), 1477-1482, 2001 | 302 | 2001 |
| Regulation of cholesterol and fatty acid synthesis J Ye, RA DeBose-Boyd Cold Spring Harbor perspectives in biology 3 (7), a004754, 2011 | 298 | 2011 |
| SREBPs in lipid metabolism, insulin signaling, and beyond RA DeBose-Boyd, J Ye Trends in biochemical sciences 43 (5), 358-368, 2018 | 288 | 2018 |
| Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase stimulated by δ-and γ-tocotrienols BL Song, RA DeBose-Boyd Journal of Biological Chemistry 281 (35), 25054-25061, 2006 | 230 | 2006 |
| Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage … RB Rawson, R DeBose-Boyd, JL Goldstein, MS Brown Journal of Biological Chemistry 274 (40), 28549-28556, 1999 | 204 | 1999 |
| Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase Y Jo, RA DeBose-Boyd Critical reviews in biochemistry and molecular biology 45 (3), 185-198, 2010 | 200 | 2010 |
| Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8 Y Jo, PCW Lee, PV Sguigna, RA DeBose-Boyd Proceedings of the National Academy of Sciences 108 (51), 20503-20508, 2011 | 184 | 2011 |
| Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78 JN Lee, B Song, RA DeBose-Boyd, J Ye Journal of Biological Chemistry 281 (51), 39308-39315, 2006 | 183 | 2006 |
| Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs AD Nguyen, JG McDonald, RK Bruick, RA DeBose-Boyd Journal of Biological Chemistry 282 (37), 27436-27446, 2007 | 156 | 2007 |
| Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver S Hwang, AD Nguyen, Y Jo, LJ Engelking, J Brugarolas, ... Journal of Biological Chemistry 292 (22), 9382-9393, 2017 | 112 | 2017 |
| Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling … IZ Hartman, P Liu, JK Zehmer, K Luby-Phelps, Y Jo, RGW Anderson, ... Journal of Biological Chemistry 285 (25), 19288-19298, 2010 | 108 | 2010 |
