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Srijit Seal
Srijit Seal
Merck, Broad Institute of MIT and Harvard, University of Cambridge
Verified email at broad.mit.edu - Homepage
Title
Cited by
Cited by
Year
Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection
S Seal, J Carreras-Puigvert, MA Trapotsi, H Yang, O Spjuth, A Bender
Communications Biology 5 (1), 858, 2022
642022
Comparison of cellular morphological descriptors and molecular fingerprints for the prediction of cytotoxicity-and proliferation-related assays
S Seal, H Yang, L Vollmers, A Bender
Chemical Research in Toxicology 34 (2), 422-437, 2021
432021
Using chemical and biological data to predict drug toxicity
A Liu, S Seal, H Yang, A Bender
SLAS Discovery 28 (3), 53-64, 2023
362023
Merging bioactivity predictions from cell morphology and chemical fingerprint models using similarity to training data
S Seal, H Yang, MA Trapotsi, S Singh, J Carreras-Puigvert, O Spjuth, ...
Journal of Cheminformatics 15 (1), 56, 2023
312023
Insights into Drug Cardiotoxicity from Biological and Chemical Data: The First Public Classifiers for FDA Drug-Induced Cardiotoxicity Rank
S Seal, O Spjuth, L Hosseini-Gerami, M García-Ortegón, S Singh, ...
Journal of Chemical Information and Modeling 64 (4), 1172-1186, 2024
202024
From pixels to phenotypes: Integrating image-based profiling with cell health data as BioMorph features improves interpretability
S Seal, J Carreras-Puigvert, S Singh, AE Carpenter, O Spjuth, A Bender
Molecular Biology of the Cell 35 (3), mr2, 2024
152024
Cell Painting: a decade of discovery and innovation in cellular imaging
S Seal, MA Trapotsi, O Spjuth, S Singh, J Carreras-Puigvert, N Greene, ...
Nature Methods, 1-15, 2024
12*2024
Using generative modeling to endow with potency initially inert compounds with good bioavailability and low toxicity
RI Horne, J Wilson-Godber, A González Díaz, ZF Brotzakis, S Seal, ...
Journal of Chemical Information and Modeling 64 (3), 590-596, 2024
112024
Cell morphology with gene expression and chemical structure to aid mitochondrial toxicity
S Seal, J Carreras-Puigvert, MA Trapotsi, H Yang, O Spjuth, A Bender
102022
Improved Detection of Drug-Induced Liver Injury by Integrating Predicted In Vivo and In Vitro Data
S Seal, D Williams, L Hosseini-Gerami, M Mahale, AE Carpenter, ...
Chemical Research in Toxicology 37 (8), 1290-1305, 2024
82024
PKSmart: An Open-Source Computational Model to Predict in vivo Pharmacokinetics of Small Molecules
S Seal, M Trapotsi, V Subramanian, O Spjuth, N Greene, A Bender
bioRxiv, 2024.02. 02.578658, 2024
62024
Understanding Biology in the Age of Artificial Intelligence
E Lawrence, A El-Shazly, S Seal, CK Joshi, P Liò, S Singh, A Bender, ...
arXiv preprint arXiv:2403.04106, 2024
42024
Calibrated prediction of scarce adverse drug reaction labels with conditional neural processes
M Garcia Ortegon, S Seal, S Singh, A Bender, S Bacallado
ICLR 2024 DMLR Workshop, 2024
22024
Out-of-Distribution Validation for Bioactivity Prediction in Drug Discovery: Lessons from Materials Science
US Saha, M Vendruscolo, AE Carpenter, S Singh, A Bender, S Seal
bioRxiv, 2024.07. 02.601740, 2024
2*2024
Learning Molecular Representation in a Cell
G Liu, S Seal, J Arevalo, Z Liang, AE Carpenter, M Jiang, S Singh
arXiv preprint arXiv:2406.12056, 2024
12024
Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes
JD Ewald, KL Titterton, A Bäuerle, A Beatson, DA Boiko, ÀA Cabrera, ...
bioRxiv, 2025.01. 22.634152, 2025
2025
Using Cell Painting and Chemical Data for Small-molecule Bioactivity and Toxicity Prediction
S Seal
2024
Graph neural processes for molecules: an evaluation on docking scores and strategies to improve generalization
M García-Ortegón, S Seal, C Rasmussen, A Bender, S Bacallado
Journal of Cheminformatics 16 (1), 115, 2024
2024
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Articles 1–18