| 2, 5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products AD Borthwick Chemical Reviews 112 (7), 3641-3716, 2012 | 987 | 2012 |
| Synthesis of chiral carbocyclic nucleosides AD Borthwick Tetrahedron 48 (4), 571-623, 1992 | 528 | 1992 |
| Design and Synthesis of monocyclic B-lactams as Mechanism-Based inhibitors of Human Cytomegalovirus Protease. AD Borthwick, GG Weingarten, TM Haley, M Tomaszewski, W Wang, Z Hu, ... Bioorganic & Medicinal Chemistry Letters 8, 365, 1998 | 209 | 1998 |
| The discovery of GSK221149A: a potent and selective oxytocin antagonist J Liddle, MJ Allen, AD Borthwick, DP Brooks, DE Davies, RM Edwards, ... Bioorganic & medicinal chemistry letters 18 (1), 90-94, 2008 | 103 | 2008 |
| 2, 5-diketopiperazines in food and beverages: Taste and bioactivity AD Borthwick, NC Da Costa Critical reviews in food science and nutrition 57 (4), 718-742, 2017 | 99 | 2017 |
| 2, 5-Diketopiperazines as potent and selective oxytocin antagonists 1: Identification, stereochemistry and initial SAR PG Wyatt, MJ Allen, AD Borthwick, DE Davies, AM Exall, RJD Hatley, ... Bioorganic & medicinal chemistry letters 15 (10), 2579-2582, 2005 | 90 | 2005 |
| Use of diethylaminosulphur trifluoride (DAST) in the preparation of synthons of carbocyclic nucleosides K Biggadike, AD Borthwick, D Evans, AM Exall, BE Kirk, SM Roberts, ... Journal of the Chemical Society, Perkin Transactions 1, 549-554, 1988 | 77 | 1988 |
| 2, 5-Diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics AD Borthwick, DE Davies, AM Exall, DG Livermore, SL Sollis, F Nerozzi, ... Journal of medicinal chemistry 48 (22), 6956-6969, 2005 | 72 | 2005 |
| Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'-and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-. beta.-D … AD Borthwick, DN Evans, BE Kirk, K Biggadike, AM Exall, P Youds, ... Journal of medicinal chemistry 33 (1), 179-186, 1990 | 70 | 1990 |
| Pyridyl-2,5-Diketopiperazines as Potent, Selective and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics and In-vivo Potency. AD Borthwick, J Liddle, DE Davies, AM Exall, C Hamlett Journal of Medicinal Chemistry 55 (2), 783–796, 2012 | 67 | 2012 |
| The Design of Orally Bioavailable 2,5-Diketopiperazine Oxytocin Antagonists: From Concept to Clinical Candidate for Premature Labour. AD Borthwick, J Liddle Medicinal Research Reviews 31 (4), 576-604, 2011 | 63 | 2011 |
| Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxohexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus … AD Borthwick, AJ Crame, PF Ertl, AM Exall, TM Haley, GJ Hart, AM Mason, ... Journal of medicinal chemistry 45 (1), 1-18, 2002 | 59 | 2002 |
| Factor Xa Inhibitors: S1 Binding Interactions of a Series of N-{(3S)-1-[(1S)-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides C Chan, AD Borthwick, D Brown, CL Burns-Kurtis, M Campbell, ... Journal of medicinal chemistry 50 (7), 1546-1557, 2007 | 57 | 2007 |
| 2, 5-Diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency AD Borthwick, DE Davies, AM Exall, RJD Hatley, JA Hughes, WR Irving, ... Journal of medicinal chemistry 49 (14), 4159-4170, 2006 | 56 | 2006 |
| Synthesis and enzymatic resolution of carbocyclic 2′-ara-fluoro-guanosine: a potent new anti-herpetic agent AD Borthwick, S Butt, K Biggadike, AM Exall, SM Roberts, PM Youds, ... Journal of the Chemical Society, Chemical Communications, 656-658, 1988 | 47 | 1988 |
| Structure-and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs RJ Young, M Campbell, AD Borthwick, D Brown, CL Burns-Kurtis, C Chan, ... Bioorganic & medicinal chemistry letters 16 (23), 5953-5957, 2006 | 44 | 2006 |
| Oral Oxytocin Antagonists AD Borthwick J.Med.Chem. 53 (18), 6525–6538, 2010 | 43 | 2010 |
| Design and Synthesis of Pyrrolidine-5,5‘-trans-Lactams (5-Oxo-hexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human … AD Borthwick, DE Davies, PF Ertl, AM Exall, TM Haley, GJ Hart, ... Journal of medicinal chemistry 46 (21), 4428-4449, 2003 | 42 | 2003 |
| Short convergent route to homochiral carbocyclic-2′-deoxynucleosides and carbocyclic ribonucleosides K Biggadike, AD Borthwick, AM Exall, BE Kirk, SM Roberts, P Youds Journal of the Chemical Society, Chemical Communications, 1083-1084, 1987 | 42 | 1987 |
| Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat GP McCafferty, MA Pullen, C Wu, RM Edwards, MJ Allen, PM Woollard, ... American Journal of Physiology-Regulatory, Integrative and Comparative …, 2007 | 40 | 2007 |
