| Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway L Sun, J Wu, F Du, X Chen, ZJ Chen Science 339 (6121), 786-791, 2013 | 4615 | 2013 |
| Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3 RB Seth, L Sun, CK Ea, ZJ Chen Cell 122 (5), 669-682, 2005 | 3924 | 2005 |
| Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA J Wu, L Sun, X Chen, F Du, H Shi, C Chen, ZJ Chen Science 339 (6121), 826-830, 2013 | 2469 | 2013 |
| TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity MU Gack, YC Shin, CH Joo, T Urano, C Liang, L Sun, O Takeuchi, S Akira, ... Nature 446 (7138), 916-920, 2007 | 1951 | 2007 |
| Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing Q Chen, L Sun, ZJ Chen Nature immunology 17 (10), 1142-1149, 2016 | 1899 | 2016 |
| MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response F Hou, L Sun, H Zheng, B Skaug, QX Jiang, ZJ Chen Cell 146 (3), 448-461, 2011 | 1406 | 2011 |
| Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects XD Li, J Wu, D Gao, H Wang, L Sun, ZJ Chen Science 341 (6152), 1390-1394, 2013 | 1168 | 2013 |
| Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses D Gao, J Wu, YT Wu, F Du, C Aroh, N Yan, L Sun, ZJ Chen Science 341 (6148), 903-906, 2013 | 1131 | 2013 |
| Nonproteolytic functions of ubiquitin in cell signaling ZJ Chen, LJ Sun Molecular cell 33 (3), 275-286, 2009 | 1130 | 2009 |
| TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains A Kanayama, RB Seth, L Sun, CK Ea, M Hong, A Shaito, YH Chiu, L Deng, ... Molecular cell 15 (4), 535-548, 2004 | 1125 | 2004 |
| Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING X Zhang, H Shi, J Wu, X Zhang, L Sun, C Chen, ZJ Chen Molecular cell 51 (2), 226-235, 2013 | 1094 | 2013 |
| Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity XD Li, L Sun, RB Seth, G Pineda, ZJ Chen Proceedings of the National Academy of Sciences of the United States of …, 2005 | 1019 | 2005 |
| The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes L Sun, L Deng, CK Ea, ZP Xia, ZJ Chen Molecular cell 14 (3), 289-301, 2004 | 877 | 2004 |
| The specific and essential role of MAVS in antiviral innate immune responses Q Sun, L Sun, HH Liu, X Chen, RB Seth, J Forman, ZJ Chen Immunity 24 (5), 633-642, 2006 | 758 | 2006 |
| Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity W Zeng, L Sun, X Jiang, X Chen, F Hou, A Adhikari, M Xu, ZJ Chen Cell 141 (2), 315-330, 2010 | 694 | 2010 |
| NLRX1 is a regulator of mitochondrial antiviral immunity CB Moore, DT Bergstralh, JA Duncan, Y Lei, TE Morrison, ... Nature 451 (7178), 573-577, 2008 | 680 | 2008 |
| The novel functions of ubiquitination in signaling L Sun, ZJ Chen Current opinion in cell biology 16 (2), 119-126, 2004 | 659 | 2004 |
| Direct activation of protein kinases by unanchored polyubiquitin chains ZP Xia, L Sun, X Chen, G Pineda, X Jiang, A Adhikari, W Zeng, ZJ Chen Nature 461 (7260), 114-119, 2009 | 658 | 2009 |
| Antiviral innate immunity pathways RB Seth, L Sun, ZJ Chen Cell research 16 (2), 141-147, 2006 | 657 | 2006 |
| cGAS is essential for the antitumor effect of immune checkpoint blockade H Wang, S Hu, X Chen, H Shi, C Chen, L Sun, ZJ Chen Proceedings of the National Academy of Sciences 114 (7), 1637-1642, 2017 | 523 | 2017 |
Daxing GaoUniversity of Science and Technology of ChinaVerified email at ustc.edu.cn