| The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K JY Gauthier, N Chauret, W Cromlish, S Desmarais, LT Duong, ... Bioorganic & medicinal chemistry letters 18 (3), 923-928, 2008 | 558 | 2008 |
| Diverse functions of macrophages in different tumor microenvironments M Yang, D McKay, JW Pollard, CE Lewis Cancer research 78 (19), 5492-5503, 2018 | 397 | 2018 |
| Theoretical calculation of substituent effects on the O− H bond strength of phenolic antioxidants related to vitamin E JS Wright, DJ Carpenter, DJ McKay, KU Ingold Journal of the American Chemical Society 119 (18), 4245-4252, 1997 | 353 | 1997 |
| Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K WC Black, CI Bayly, DE Davis, S Desmarais, JP Falgueyret, S Léger, ... Bioorganic & medicinal chemistry letters 15 (21), 4741-4744, 2005 | 177 | 2005 |
| How long can you make an oxygen chain? DJ Mckay, JS Wright Journal of the American Chemical Society 120 (5), 1003-1013, 1998 | 131 | 1998 |
| Allele-specific mechanisms of activation of MEK1 mutants determine their properties Y Gao, MT Chang, D McKay, N Na, B Zhou, R Yaeger, NM Torres, ... Cancer discovery 8 (5), 648-661, 2018 | 128 | 2018 |
| Identification of a potent and selective non-basic cathepsin K inhibitor CS Li, D Deschenes, S Desmarais, JP Falgueyret, JY Gauthier, ... Bioorganic & medicinal chemistry letters 16 (7), 1985-1989, 2006 | 98 | 2006 |
| The identification of potent, selective, and bioavailable cathepsin S inhibitors JY Gauthier, WC Black, I Courchesne, W Cromlish, S Desmarais, R Houle, ... Bioorganic & medicinal chemistry letters 17 (17), 4929-4933, 2007 | 80 | 2007 |
| Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro) methyl] phosphonic acid, a potent and orally active small molecule PTP1B inhibitor Y Han, M Belley, CI Bayly, J Colucci, C Dufresne, A Giroux, CK Lau, ... Bioorganic & medicinal chemistry letters 18 (11), 3200-3205, 2008 | 76 | 2008 |
| Allosteric mutant IDH1 inhibitors reveal mechanisms for IDH1 mutant and isoform selectivity X Xie, D Baird, K Bowen, V Capka, J Chen, G Chenail, YS Cho, J Dooley, ... Structure 25 (3), 506-513, 2017 | 64 | 2017 |
| Diastereoselective reductive amination of aryl trifluoromethyl ketones and α‐amino esters G Hughes, PN Devine, JR Naber, PD O'Shea, BS Foster, DJ McKay, ... Angewandte Chemie International Edition 46 (11), 1839-1842, 2007 | 63 | 2007 |
| LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors KA Monaco, S Delach, J Yuan, Y Mishina, P Fordjour, E Labrot, D McKay, ... Clinical cancer research 27 (7), 2061-2073, 2021 | 61 | 2021 |
| Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors Y Han, A Giroux, J Colucci, CI Bayly, DJ Mckay, S Roy, S Xanthoudakis, ... Bioorganic & medicinal chemistry letters 15 (4), 1173-1180, 2005 | 54 | 2005 |
| β-Substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K SN Crane, WC Black, JT Palmer, DE Davis, E Setti, J Robichaud, ... Journal of medicinal chemistry 49 (3), 1066-1079, 2006 | 47 | 2006 |
| Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors Y Han, A Giroux, EL Grimm, R Aspiotis, S Francoeur, CI Bayly, DJ Mckay, ... Bioorganic & medicinal chemistry letters 14 (3), 805-808, 2004 | 45 | 2004 |
| Could AlphaFold revolutionize chemical therapeutics? AB Tong, JD Burch, D McKay, C Bustamante, MA Crackower, H Wu Nature structural & molecular biology 28 (10), 771-772, 2021 | 43 | 2021 |
| Estimation of solvation entropy and enthalpy via analysis of water oxygen–hydrogen correlations C Velez-Vega, DJJ McKay, T Kurtzman, V Aravamuthan, RA Pearlstein, ... Journal of chemical theory and computation 11 (11), 5090-5102, 2015 | 38 | 2015 |
| Nicotinyl aspartyl ketones as inhibitors of caspase-3 E Isabel, WC Black, CI Bayly, EL Grimm, MK Janes, DJ McKay, ... Bioorganic & medicinal chemistry letters 13 (13), 2137-2140, 2003 | 37 | 2003 |
| Uncoupling the structure–activity relationships of β2 adrenergic receptor ligands from membrane binding CJ Dickson, V Hornak, C Velez-Vega, DJJ McKay, J Reilly, DA Sandham, ... Journal of medicinal chemistry 59 (12), 5780-5789, 2016 | 35 | 2016 |
| Time-averaged distributions of solute and solvent motions: exploring proton wires of GFP and PfM2DH C Velez-Vega, DJJ McKay, V Aravamuthan, R Pearlstein, JS Duca Journal of chemical information and modeling 54 (12), 3344-3361, 2014 | 33 | 2014 |
James S. WrightDistinguished Research Professor, Carleton UniversityVerified email at carleton.ca
