| β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE R Vassar, BD Bennett, S Babu-Khan, S Kahn, EA Mendiaz, P Denis, ... science 286 (5440), 735-741, 1999 | 5337 | 1999 |
| Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque … H Oakley, SL Cole, S Logan, E Maus, P Shao, J Craft, ... Journal of Neuroscience 26 (40), 10129-10140, 2006 | 3682 | 2006 |
| Topographic organization of sensory projections to the olfactory bulb R Vassar, SK Chao, R Sitcheran, JM Nun, LB Vosshall, R Axel Cell 79 (6), 981-991, 1994 | 1548 | 1994 |
| Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation Y Luo, B Bolon, S Kahn, BD Bennett, S Babu-Khan, P Denis, W Fan, ... Nature neuroscience 4 (3), 231-232, 2001 | 1447 | 2001 |
| Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium R Vassar, J Ngai, R Axel Cell 74 (2), 309-318, 1993 | 1080 | 1993 |
| The secretases: enzymes with therapeutic potential in Alzheimer disease B De Strooper, R Vassar, T Golde Nature reviews neurology 6 (2), 99-107, 2010 | 982 | 2010 |
| APP mouse models for Alzheimer's disease preclinical studies H Sasaguri, P Nilsson, S Hashimoto, K Nagata, T Saito, B De Strooper, ... The EMBO journal 36 (17), 2473-2487, 2017 | 799 | 2017 |
| Targeting the β secretase BACE1 for Alzheimer's disease therapy R Yan, R Vassar The Lancet Neurology 13 (3), 319-329, 2014 | 790 | 2014 |
| The β-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential R Vassar, DM Kovacs, R Yan, PC Wong Journal of neuroscience 29 (41), 12787-12794, 2009 | 734 | 2009 |
| BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease M Ohno, EA Sametsky, LH Younkin, H Oakley, SG Younkin, M Citron, ... Neuron 41 (1), 27-33, 2004 | 707 | 2004 |
| The Alzheimer's disease β-secretase enzyme, BACE1 SL Cole, R Vassar Molecular neurodegeneration 2, 1-25, 2007 | 699 | 2007 |
| Anti-inflammatory drug therapy alters β-amyloid processing and deposition in an animal model of Alzheimer's disease Q Yan, J Zhang, H Liu, S Babu-Khan, R Vassar, AL Biere, M Citron, ... Journal of Neuroscience 23 (20), 7504-7509, 2003 | 676 | 2003 |
| The β-secretase BACE1 in Alzheimer’s disease H Hampel, R Vassar, B De Strooper, J Hardy, M Willem, N Singh, J Zhou, ... Biological psychiatry 89 (8), 745-756, 2021 | 591 | 2021 |
| Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease R Vassar, PA Coulombe, L Degenstein, K Albers, E Fuchs Cell 64 (2), 365-380, 1991 | 521 | 1991 |
| Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. R Vassar, E Fuchs Genes & development 5 (5), 714-727, 1991 | 517 | 1991 |
| Phosphorylation of the translation initiation factor eIF2α increases BACE1 levels and promotes amyloidogenesis T O'Connor, KR Sadleir, E Maus, RA Velliquette, J Zhao, SL Cole, ... Neuron 60 (6), 988-1009, 2008 | 516 | 2008 |
| Bace 1: The β-secretase enzyme in alzheimer’s disease R Vassar Journal of Molecular Neuroscience 23, 105-113, 2004 | 512 | 2004 |
| BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease R Vassar Alzheimer's research & therapy 6 (9), 89, 2014 | 475 | 2014 |
| Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. R Vassar, M Rosenberg, S Ross, A Tyner, E Fuchs Proceedings of the National Academy of Sciences 86 (5), 1563-1567, 1989 | 468 | 1989 |
| Expression analysis of BACE2 in brain and peripheral tissues BD Bennett, S Babu-Khan, R Loeloff, JC Louis, E Curran, M Citron, ... Journal of Biological Chemistry 275 (27), 20647-20651, 2000 | 452 | 2000 |