| Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice KC Luk, V Kehm, J Carroll, B Zhang, P O’Brien, JQ Trojanowski, VMY Lee Science 338 (6109), 949-953, 2012 | 2681 | 2012 |
| Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death LA Volpicelli-Daley, KC Luk, TP Patel, SA Tanik, DM Riddle, A Stieber, ... Neuron 72 (1), 57-71, 2011 | 1736 | 2011 |
| Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice KC Luk, VM Kehm, B Zhang, P O’Brien, JQ Trojanowski, VMY Lee Journal of Experimental Medicine 209 (5), 975-986, 2012 | 1248 | 2012 |
| Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells KC Luk, C Song, P O'Brien, A Stieber, JR Branch, KR Brunden, ... Proceedings of the National Academy of Sciences 106 (47), 20051-20056, 2009 | 1126 | 2009 |
| Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates LA Volpicelli-Daley, KC Luk, VMY Lee Nature protocols 9 (9), 2135-2146, 2014 | 706 | 2014 |
| Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies C Peng, RJ Gathagan, DJ Covell, C Medellin, A Stieber, JL Robinson, ... Nature 557 (7706), 558-563, 2018 | 593 | 2018 |
| Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration KL Paumier, KC Luk, FP Manfredsson, NM Kanaan, JW Lipton, TJ Collier, ... Neurobiology of disease 82, 185-199, 2015 | 429 | 2015 |
| Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease NL Rey, JA Steiner, N Maroof, KC Luk, Z Madaj, JQ Trojanowski, ... Journal of Experimental Medicine 213 (9), 1759-1778, 2016 | 406 | 2016 |
| α-Synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration HT Tran, CHY Chung, M Iba, B Zhang, JQ Trojanowski, KC Luk, VMY Lee Cell reports 7 (6), 2054-2065, 2014 | 387 | 2014 |
| Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons P Van den Munckhof, KC Luk, L Ste-Marie, J Montgomery, PJ Blanchet, ... Oxford University Press for The Company of Biologists Limited 130 (11), 2535 …, 2003 | 354 | 2003 |
| Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism VR Osterberg, KJ Spinelli, LJ Weston, KC Luk, RL Woltjer, VK Unni Cell reports 10 (8), 1252-1260, 2015 | 271 | 2015 |
| Best practices for generating and using alpha-synuclein pre-formed fibrils to model Parkinson’s disease in rodents NK Polinski, LA Volpicelli-Daley, CE Sortwell, KC Luk, N Cremades, ... Journal of Parkinson's disease 8 (2), 303-322, 2018 | 269 | 2018 |
| Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders AJ Schaser, VR Osterberg, SE Dent, TL Stackhouse, CM Wakeham, ... Scientific reports 9 (1), 10919, 2019 | 251 | 2019 |
| Neurogenesis and stereological morphometry of calretinin‐immunoreactive GABAergic interneurons of the neostriatum VV Rymar, R Sasseville, KC Luk, AF Sadikot Journal of comparative neurology 469 (3), 325-339, 2004 | 244 | 2004 |
| Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain P Thakur, LS Breger, M Lundblad, OW Wan, B Mattsson, KC Luk, ... Proceedings of the National Academy of Sciences 114 (39), E8284-E8293, 2017 | 240 | 2017 |
| Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration MF Duffy, TJ Collier, JR Patterson, CJ Kemp, KC Luk, MG Tansey, ... Journal of neuroinflammation 15, 1-18, 2018 | 222 | 2018 |
| Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term NL Rey, S George, JA Steiner, Z Madaj, KC Luk, JQ Trojanowski, ... Acta neuropathologica 135, 65-83, 2018 | 213 | 2018 |
| Molecular and biological compatibility with host alpha-synuclein influences fibril pathogenicity KC Luk, DJ Covell, VM Kehm, B Zhang, IY Song, MD Byrne, RM Pitkin, ... Cell reports 16 (12), 3373-3387, 2016 | 190 | 2016 |
| Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology FP Manfredsson, KC Luk, MJ Benskey, A Gezer, J Garcia, NC Kuhn, ... Neurobiology of disease 112, 106-118, 2018 | 179 | 2018 |
| GABA promotes survival but not proliferation of parvalbumin-immunoreactive interneurons in rodent neostriatum: an in vivo study with stereology KC Luk, AF Sadikot Neuroscience 104 (1), 93-103, 2001 | 155 | 2001 |
abbas sadikotWilliam V. Cone Professor, Montreal Neurological Institute, McGill UniversityVerified email at mcgill.ca
