| Metabolic gatekeeper function of B-lymphoid transcription factors LN Chan, Z Chen, D Braas, JW Lee, G Xiao, H Geng, KN Cosgun, C Hurtz, ... Nature 542 (7642), 479-483, 2017 | 237 | 2017 |
| BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition C Duy, C Hurtz, S Shojaee, L Cerchietti, H Geng, S Swaminathan, ... Nature 473 (7347), 384-388, 2011 | 220 | 2011 |
| BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia C Hurtz, K Hatzi, L Cerchietti, M Braig, E Park, Y Kim, S Herzog, ... Journal of Experimental Medicine 208 (11), 2163-2174, 2011 | 200 | 2011 |
| BCL6 is critical for the development of a diverse primary B cell repertoire C Duy, JJ Yu, R Nahar, S Swaminathan, SM Kweon, JM Polo, E Valls, ... Journal of Experimental Medicine 207 (6), 1209-1221, 2010 | 147 | 2010 |
| Erk negative feedback control enables pre-B cell transformation and represents a therapeutic target in acute lymphoblastic leukemia S Shojaee, R Caeser, M Buchner, E Park, S Swaminathan, C Hurtz, ... Cancer cell 28 (1), 114-128, 2015 | 136 | 2015 |
| Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia H Geng, C Hurtz, KB Lenz, Z Chen, D Baumjohann, S Thompson, ... Cancer cell 27 (3), 409-425, 2015 | 135 | 2015 |
| BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint S Swaminathan, C Huang, H Geng, Z Chen, R Harvey, H Kang, C Ng, ... Nature medicine 19 (8), 1014-1022, 2013 | 121 | 2013 |
| Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia B Kharabi Masouleh, H Geng, C Hurtz, LN Chan, AC Logan, MS Chang, ... Proceedings of the National Academy of Sciences 111 (21), E2219-E2228, 2014 | 107 | 2014 |
| High incidence of Philadelphia chromosome-like acute lymphoblastic leukemia in older adults with B-ALL SK Tasian, C Hurtz, GB Wertheim, NG Bailey, MS Lim, RC Harvey, ... Leukemia 31 (4), 981-984, 2017 | 105 | 2017 |
| Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK E Kim, C Hurtz, S Koehrer, Z Wang, S Balasubramanian, BY Chang, ... Blood, The Journal of the American Society of Hematology 129 (9), 1155-1165, 2017 | 96 | 2017 |
| Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia H Geng, S Brennan, TA Milne, WY Chen, Y Li, C Hurtz, SM Kweon, L Zickl, ... Cancer discovery 2 (11), 1004-1023, 2012 | 90 | 2012 |
| SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia P Ramezani-Rad, H Geng, C Hurtz, LN Chan, Z Chen, H Jumaa, ... Blood, The Journal of the American Society of Hematology 121 (1), 148-155, 2013 | 86 | 2013 |
| Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition S Köhrer, O Havranek, F Seyfried, C Hurtz, GP Coffey, E Kim, ... Leukemia 30 (6), 1246-1254, 2016 | 83 | 2016 |
| Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures NA Graham, A Minasyan, A Lomova, A Cass, NG Balanis, M Friedman, ... Molecular systems biology 13 (2), 914, 2017 | 80 | 2017 |
| Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease R Deng, C Hurtz, Q Song, C Yue, G Xiao, H Yu, X Wu, M Muschen, ... Nature communications 8 (1), 978, 2017 | 63 | 2017 |
| Signalling input from divergent pathways subverts B cell transformation LN Chan, MA Murakami, ME Robinson, R Caeser, T Sadras, J Lee, ... Nature 583 (7818), 845-851, 2020 | 56 | 2020 |
| O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia R Parameswaran, M Lim, A Arutyunyan, H Abdel-Azim, C Hurtz, K Lau, ... Journal of Experimental Medicine 210 (4), 805-819, 2013 | 49 | 2013 |
| Activated natural killer cells predict poor clinical prognosis in high-risk B-and T-cell acute lymphoblastic leukemia C Duault, A Kumar, A Taghi Khani, SJ Lee, L Yang, M Huang, C Hurtz, ... Blood, The Journal of the American Society of Hematology 138 (16), 1465-1480, 2021 | 48 | 2021 |
| Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL C Hurtz, GB Wertheim, JP Loftus, D Blumenthal, A Lehman, Y Li, ... The Journal of clinical investigation 130 (7), 3637-3653, 2020 | 40 | 2020 |
| Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia C Hurtz, LN Chan, H Geng, E Ballabio, G Xiao, G Deb, H Khoury, ... Genes & development 33 (17-18), 1265-1279, 2019 | 24 | 2019 |
Huimin GengAssociate Adjunct Professor, UCSFVerified email at ucsf.edu