Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease MW Beck, JS Derrick, RA Kerr, SB Oh, WJ Cho, SJC Lee, Y Ji, J Han, ... Nature Communications 7 (1), 13115, 2016 | 86 | 2016 |
A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease MW Beck, SB Oh, RA Kerr, HJ Lee, SH Kim, S Kim, M Jang, BT Ruotolo, ... Chemical Science 6 (3), 1879-1886, 2015 | 77 | 2015 |
Reactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species AS Pithadia, A Kochi, MT Soper, MW Beck, Y Liu, S Lee, AS DeToma, ... Inorganic chemistry 51 (23), 12959-12967, 2012 | 52 | 2012 |
Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications Y Liu, A Kochi, AS Pithadia, S Lee, Y Nam, MW Beck, X He, D Lee, ... Inorganic chemistry 52 (14), 8121-8130, 2013 | 41 | 2013 |
Human carboxylesterases and fluorescent probes to image their activity in live cells A Singh, M Gao, MW Beck RSC Medicinal Chemistry 12 (7), 1142-1153, 2021 | 34 | 2021 |
Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues MW Beck, RS Kathayat, CM Cham, EB Chang, BC Dickinson Chemical science 8 (11), 7588-7592, 2017 | 31 | 2017 |
A Fluorescent Probe with Improved Water Solubility Permits the Analysis of Protein S-Depalmitoylation Activity in Live Cells T Qiu, RS Kathayat, Y Cao, MW Beck, BC Dickinson Biochemistry 57 (2), 221-225, 2018 | 24 | 2018 |
Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease MW Beck, JS Derrick, JM Suh, M Kim, KJ Korshavn, RA Kerr, WJ Cho, ... ChemMedChem 12 (22), 1828-1838, 2017 | 17 | 2017 |
Ligand Design to Target and Modulate Metal–Protein Interactions in Neurodegenerative Diseases MW Beck, AS Pithadia, AS DeToma, KJ Korshavn, MH Lim Ligand Design in Medicinal Inorganic Chemistry, 257-286, 2014 | 6 | 2014 |
Carbonate‐Based Fluorescent Chemical Tool for Uncovering Carboxylesterase 1 (CES1) Activity Variations in Live Cells A Singh, M Gao, CJ Karns, TP Spidle, MW Beck ChemBioChem 23 (12), e202200069, 2022 | 4 | 2022 |
Fluorogenic chemical tools to shed light on CES1-mediated adverse drug interactions CJ Karns, TP Spidle, E Adusah, M Gao, JE Nehls, MW Beck Chemical Communications, 2024 | 1 | 2024 |
Fluorescein Diacetate (FDA) Should Not Be Used to Study Human Carboxylesterase 2 (CES2) in Complex Biological Systems Without Validation CJ Karns, A Singh, MR Walk, E Adusah, AM Pearson, MW Beck | | 2025 |
Synthetic substrates for enzymes that catalyze reactions of modified cysteines and related methods BC Dickinson, RS Kathayat, MW Beck US Patent 10,413,583, 2019 | | 2019 |
Front Cover: Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease (ChemMedChem 22/2017) MW Beck, JS Derrick, JM Suh, M Kim, KJ Korshavn, RA Kerr, WJ Cho, ... ChemMedChem 12 (22), 1818-1818, 2017 | | 2017 |
Development of Small Molecules as Chemical Tools for Investigating the Role of Metal-Protein Interactions in Neurodegenerative Diseases. MW Beck | | 2015 |