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Kaja Kostyrko
Kaja Kostyrko
Verified email at ucsf.edu
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Year
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities
K Han, SE Pierce, A Li, K Spees, GR Anderson, JA Seoane, YH Lo, ...
Nature 580 (7801), 136-141, 2020
2712020
The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses
K Blaszczyk, H Nowicka, K Kostyrko, A Antonczyk, J Wesoly, ...
Cytokine & growth factor reviews 29, 71-81, 2016
1632016
STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1
K Blaszczyk, A Olejnik, H Nowicka, L Ozgyin, YL Chen, S Chmielewski, ...
Biochemical Journal 466 (Pt 3), 511, 2015
1112015
High-level transgene expression by homologous recombination-mediated gene transfer
M Grandjean, PA Girod, D Calabrese, K Kostyrko, M Wicht, F Yerly, ...
Nucleic acids research 39 (15), e104-e104, 2011
812011
Antitumor activity of an engineered decoy receptor targeting CLCF1–CNTFR signaling in lung adenocarcinoma
JW Kim, CP Marquez, K Kostyrko, AL Koehne, K Marini, DR Simpson, ...
Nature medicine 25 (11), 1783-1795, 2019
642019
Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy
KD Marini, DR Croucher, RA McCloy, V Vaghjiani, A Gonzalez-Rajal, ...
Science translational medicine 10 (451), eaat3504, 2018
462018
Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms
K Kostyrko, N Mermod
Nucleic acids research 44 (6), e56-e56, 2016
432016
Combined proteomic and genetic interaction mapping reveals new RAS effector pathways and susceptibilities
MR Kelly, K Kostyrko, K Han, NA Mooney, EE Jeng, K Spees, PT Dinh, ...
Cancer discovery 10 (12), 1950-1967, 2020
372020
The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas
K Valencia, O Erice, K Kostyrko, S Hausmann, E Guruceaga, A Tathireddy, ...
The Journal of clinical investigation 130 (4), 1879-1895, 2020
352020
A role for homologous recombination proteins in cell cycle regulation
K Kostyrko, S Bosshard, Z Urban, N Mermod
Cell Cycle 14 (17), 2853-2861, 2015
322015
MAR‐Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering
K Kostyrko, S Neuenschwander, T Junier, A Regamey, C Iseli, ...
Biotechnology and bioengineering 114 (2), 384-396, 2017
282017
Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance
V Thatikonda, H Lu, S Jurado, K Kostyrko, CA Bristow, K Bosch, N Feng, ...
bioRxiv, 2023
152023
UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma
K Kostyrko, M Román, AG Lee, DR Simpson, PT Dinh, SG Leung, ...
Nature communications 14 (1), 3966, 2023
142023
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance
V Thatikonda, H Lyu, S Jurado, K Kostyrko, CA Bristow, C Albrecht, ...
Nature Cancer 5 (9), 1352-1370, 2024
82024
Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance. bioRxiv, 2023 …
V Thatikonda, H Lu, S Jurado, K Kostyrko, CA Bristow, K Bosch, N Feng, ...
Academic Search, 2023
52023
SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma
BR Daley, NE Sealover, E Sheffels, JM Hughes, D Gerlach, MH Hofmann, ...
bioRxiv, 2023
32023
Reshaping the Tumor Microenvironment of KRASG12D Pancreatic Ductal Adenocarcinoma with Combined SOS1 and MEK Inhibition for Improved Immunotherapy …
RJ Norgard, P Budhani, SA O'Brien, Y Xia, JN Egan, B Flynn, JR Tagore, ...
Cancer Research Communications 4 (6), 1548-1560, 2024
22024
Pharmacological SOS1 inhibitor BI-3406 demonstrates in vivo anti-tumor activity comparable to SOS1 genetic ablation in KRAS mutant tumors
FC Baltanas, M Kramer-Drauberg, R Garcia-Navas, E Patrucco, E Petrini, ...
bioRxiv, 2024.09. 18.613686, 2024
22024
25: STAT2 and IRF9-dependent IFN-I signaling restores ISRE-mediated transcription and anti-viral activity independent of STAT1
K Błaszczyk, A Olejnik, S Chmielewski, K Kostyrko, J Wesoly, CK Lee, ...
Cytokine 63 (3), 248-249, 2013
22013
SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
BR Daley, NE Sealover, BA Finniff, JM Hughes, E Sheffels, D Gerlach, ...
Cancer Research 85 (1), 118-133, 2025
12025
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