| AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity CM Chresta, BR Davies, I Hickson, T Harding, S Cosulich, SE Critchlow, ... Cancer research 70 (1), 288-298, 2010 | 946 | 2010 |
| hFis1, a novel component of the mammalian mitochondrial fission machinery DI James, PA Parone, Y Mattenberger, JC Martinou Journal of Biological Chemistry 278 (38), 36373-36379, 2003 | 814 | 2003 |
| Mitochondrial bioenergetics and structural network organization G Benard, N Bellance, D James, P Parrone, H Fernandez, T Letellier, ... Journal of cell science 120 (5), 838-848, 2007 | 761 | 2007 |
| Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA PA Parone, S Da Cruz, D Tondera, Y Mattenberger, DI James, P Maechler, ... PloS one 3 (9), e3257, 2008 | 499 | 2008 |
| Role of mitochondrial membrane permeabilization in apoptosis and cancer J Henry-Mowatt, C Dive, JC Martinou, D James Oncogene 23 (16), 2850-2860, 2004 | 355 | 2004 |
| Selective loss of PARG restores PARylation and counteracts PARP inhibitor-mediated synthetic lethality E Gogola, AA Duarte, JR de Ruiter, WW Wiegant, JA Schmid, R de Bruijn, ... Cancer cell 33 (6), 1078-1093. e12, 2018 | 308 | 2018 |
| Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis PA Parone, DI James, S Da Cruz, Y Mattenberger, O Donzé, F Barja, ... Molecular and cellular biology, 2006 | 285 | 2006 |
| Ca2+ homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1 M Frieden, D James, C Castelbou, A Danckaert, JC Martinou, ... Journal of Biological Chemistry 279 (21), 22704-22714, 2004 | 240 | 2004 |
| The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis E Alirol, D James, D Huber, A Marchetto, L Vergani, JC Martinou, ... Molecular biology of the cell 17 (11), 4593-4605, 2006 | 178 | 2006 |
| Mitochondria: regulating the inevitable PA Parone, D James, JC Martinou Biochimie 84 (2-3), 105-111, 2002 | 178 | 2002 |
| BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1 B Carpenter, KJ Hill, M Charalambous, KJ Wagner, D Lahiri, DI James, ... Molecular and cellular biology 24 (2), 537-549, 2004 | 172 | 2004 |
| Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin Y Mattenberger, DI James, JC Martinou FEBS letters 538 (1-3), 53-59, 2003 | 148 | 2003 |
| First-in-class chemical probes against poly (ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to olaparib DI James, KM Smith, AM Jordan, EE Fairweather, LA Griffiths, ... ACS chemical biology 11 (11), 3179-3190, 2016 | 144 | 2016 |
| Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells P Sini, D James, C Chresta, S Guichard Autophagy 6 (4), 553-554, 2010 | 117 | 2010 |
| DNA replication vulnerabilities render ovarian cancer cells sensitive to poly (ADP-ribose) glycohydrolase inhibitors N Pillay, A Tighe, L Nelson, S Littler, C Coulson-Gilmer, N Bah, A Golder, ... Cancer Cell 35 (3), 519-533. e8, 2019 | 112 | 2019 |
| Specific killing of DNA damage-response deficient cells with inhibitors of poly (ADP-ribose) glycohydrolase P Gravells, E Grant, KM Smith, DI James, HE Bryant DNA repair 52, 81-91, 2017 | 89 | 2017 |
| Novel steroid inhibitors of glucose 6-phosphate dehydrogenase NM Hamilton, M Dawson, EE Fairweather, NS Hamilton, JR Hitchin, ... Journal of medicinal chemistry 55 (9), 4431-4445, 2012 | 73 | 2012 |
| The development of an immunohistochemical method to detect the autophagy-associated protein LC3-II in human tumor xenografts SV Holt, B Wyspianska, KJ Randall, D James, JR Foster, RW Wilkinson Toxicologic pathology 39 (3), 516-523, 2011 | 63 | 2011 |
| Radiosensitization with an inhibitor of poly (ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib P Gravells, J Neale, E Grant, A Nathubhai, KM Smith, DI James, ... DNA repair 61, 25-36, 2018 | 57 | 2018 |
| Regulation of ALT-associated homology-directed repair by polyADP-ribosylation SM Hoang, N Kaminski, R Bhargava, J Barroso-González, ML Lynskey, ... Nature structural & molecular biology 27 (12), 1152-1164, 2020 | 48 | 2020 |