Computational approaches streamlining drug discovery AV Sadybekov, V Katritch Nature 616 (7958), 673-685, 2023 | 558 | 2023 |
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds AA Sadybekov, AV Sadybekov, Y Liu, C Iliopoulos-Tsoutsouvas, ... Nature 601 (7893), 452-459, 2022 | 294 | 2022 |
Structural basis for selectivity and diversity in angiotensin II receptors H Zhang, GW Han, A Batyuk, A Ishchenko, KL White, N Patel, ... Nature 544 (7650), 327-332, 2017 | 241 | 2017 |
An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio A Sadybekov, C Tian, C Arnesano, V Katritch, BE Herring Nature communications 8 (1), 1-13, 2017 | 109 | 2017 |
Optical Control of Cannabinoid Receptor 2-Mediated Ca2+ Release Enabled by Synthesis of Photoswitchable Probes RC Sarott, AEG Viray, P Pfaff, A Sadybekov, G Rajic, V Katritch, ... Journal of the American Chemical Society 143 (2), 736-743, 2021 | 49 | 2021 |
An intellectual disability-related missense mutation in Rac1 prevents LTP induction C Tian, Y Kay, A Sadybekov, S Rao, V Katritch, BE Herring Frontiers in Molecular Neuroscience 11, 223, 2018 | 34 | 2018 |
Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR AA Sadybekov, RL Brouillette, E Marin, AV Sadybekov, A Luginina, ... Biomolecules 10 (12), 1634, 2020 | 26 | 2020 |
Structural insights on ligand recognition at the human leukotriene B4 receptor 1 N Michaelian, A Sadybekov, É Besserer-Offroy, GW Han, ... Nature communications 12 (1), 2971, 2021 | 19 | 2021 |
Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats Y Kay, L Tsan, EA Davis, C Tian, L Décarie-Spain, A Sadybekov, ... Nature Communications 13 (1), 798, 2022 | 16 | 2022 |
Eosinophils protect pressure overload-and β-adrenoreceptor agonist-induced cardiac hypertrophy C Yang, J Li, Z Deng, S Luo, J Liu, W Fang, F Liu, T Liu, X Zhang, Y Zhang, ... Cardiovascular Research 119 (1), 195-212, 2023 | 11 | 2023 |
Germline selection of PTPN11 (HGNC:9644) variants make a major contribution to both Noonan syndrome's high birth rate and the transmission of sporadic cancer … J Eboreime, SK Choi, SR Yoon, A Sadybekov, V Katritch, P Calabrese, ... Human Mutation 43 (12), 2205-2221, 2022 | 8 | 2022 |
Breaking the Enigma Code of Angiotensin II Type 2 Receptor Signaling A Sadybekov, V Katritch Structure 28 (4), 390-392, 2020 | 8 | 2020 |
Virtual Screening of a Chemically Diverse “Superscaffold” Library Enables Ligand Discovery for a Key GPCR Target K Grotsch, AV Sadybekov, S Hiller, S Zaidi, D Eremin, A Le, Y Liu, ... ACS Chemical Biology 19 (4), 866-874, 2024 | 6 | 2024 |
Chiral Me-2-arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates with Stability to COX-2 SP Nikas, L Ji, Y Liu, MO Georgiadis, A Dopeshwarkar, A Straiker, ... ACS Medicinal Chemistry Letters, 2024 | 1 | 2024 |
Development of Calcium-Dependent Phospholipase A2 Inhibitors to Target Cellular Senescence and Oxidative Stress in Neurodegenerative Diseases C Hugo, I Asante, A Sadybekov, V Katritch, HN Yassine Antioxidants & Redox Signaling, 2024 | | 2024 |
Detection of autism spectrum disorder-related pathogenic trio variants by a novel structure-based approach S Rao, A Sadybekov, DC DeWitt, J Lipka, V Katritch, BE Herring Molecular Autism 15 (1), 12, 2024 | | 2024 |