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Xianwei Chen
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ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response
C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, ...
Cell stem cell 28 (2), 331-342. e5, 2021
2032021
Modeling sporadic Alzheimer's disease in human brain organoids under serum exposure
X Chen, G Sun, E Tian, M Zhang, H Davtyan, TG Beach, EM Reiman, ...
Advanced Science 8 (18), 2101462, 2021
1322021
GFAP mutations in astrocytes impair oligodendrocyte progenitor proliferation and myelination in an hiPSC model of Alexander disease
L Li, E Tian, X Chen, J Chao, J Klein, Q Qu, G Sun, G Sun, Y Huang, ...
Cell stem cell 23 (2), 239-251. e6, 2018
1242018
Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis
Q Cui, K Yin, X Zhang, P Ye, X Chen, J Chao, H Meng, J Wei, D Roeth, ...
Nature cancer 2 (9), 932-949, 2021
1062021
Modeling human cytomegalovirus-induced microcephaly in human iPSC-derived brain organoids
G Sun, F Chiuppesi, X Chen, C Wang, E Tian, J Nguyen, M Kha, D Trinh, ...
Cell Reports Medicine 1 (1), 2020
912020
Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases
Z Wang, J Zhang, Y Wang, R Xing, C Yi, H Zhu, X Chen, J Guo, W Guo, ...
Carcinogenesis 34 (1), 128-138, 2013
862013
A comprehensive proteomics analysis reveals a secretory path-and status-dependent signature of exosomes released from tumor-associated macrophages
Y Zhu, X Chen, Q Pan, Y Wang, S Su, C Jiang, Y Li, N Xu, L Wu, X Lou, ...
Journal of proteome research 14 (10), 4319-4331, 2015
822015
Genomic variants in mouse model induced by azoxymethane and dextran sodium sulfate improperly mimic human colorectal cancer
Q Pan, X Lou, J Zhang, Y Zhu, F Li, Q Shan, X Chen, Y Xie, S Su, H Wei, ...
Scientific reports 7 (1), 25, 2017
512017
Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia
Y Zhu, X He, YC Lin, H Dong, L Zhang, X Chen, Z Wang, Y Shen, M Li, ...
Blood, The Journal of the American Society of Hematology 134 (15), 1257-1268, 2019
362019
Cell‐based therapy for canavan disease using human iPSC‐derived NPCs and OPCs
L Feng, J Chao, E Tian, L Li, P Ye, M Zhang, X Chen, Q Cui, G Sun, ...
Advanced Science 7 (23), 2002155, 2020
272020
Lowering endogenous cathepsin D abundance results in reactive oxygen species accumulation and cell senescence
S Su, X Zhu, L Lin, X Chen, Y Wang, J Zi, Y Dong, Y Xie, Y Zhu, J Zhang, ...
Molecular & Cellular Proteomics 16 (7), 1217-1232, 2017
192017
Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model
Z Liu, J Chao, C Wang, G Sun, D Roeth, W Liu, X Chen, L Li, E Tian, ...
Cell reports 42 (8), 2023
172023
mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances
X Chen, Y Zhu, Z Wang, H Zhu, Q Pan, S Su, Y Dong, L Li, H Zhang, L Wu, ...
Journal of proteomics 136, 13-24, 2016
132016
Therapeutic development for Canavan disease using patient iPSCs introduced with the wild-type ASPA gene
J Chao, L Feng, P Ye, X Chen, Q Cui, G Sun, T Zhou, E Tian, W Li, W Hu, ...
IScience 25 (6), 2022
92022
Nuclear phosphoproteomics analysis reveals that CDK1/2 are involved in EGF-regulated constitutive pre-mRNA splicing in MDA-MB-468 cells
X Chen, D Guo, Y Zhu, F Xian, S Liu, L Wu, X Lou
Journal of Proteomics 141, 77-84, 2016
52016
Human induced pluripotent stem cell–based modeling of Alzheimer’s disease, a glial perspective
X Chen, Q Yang, Z Liu, Y Shi
iPSCs for Modeling Central Nervous System Disorders, 21-35, 2021
32021
Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids
X Chen, G Sun, L Feng, E Tian, Y Shi
Communications Biology 8 (1), 30, 2025
2025
Generating Homogeneous Brain Organoids from Human iPSCs
X Chen, Y Shi
Cerebral Cortex Development: Methods and Protocols, 157-167, 2024
2024
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Articles 1–18