| Structural insight into small molecule action on Frizzleds P Kozielewicz, A Turku, CF Bowin, J Petersen, J Valnohova, MCA Cañizal, ... Nature communications 11 (1), 414, 2020 | 60 | 2020 |
| Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs L Xu, B Chen, H Schihada, SC Wright, A Turku, Y Wu, GW Han, ... Cell research 31 (12), 1311-1314, 2021 | 37 | 2021 |
| Molecular pharmacology of class F receptor activation P Kozielewicz, A Turku, G Schulte Molecular pharmacology 97 (2), 62-71, 2020 | 36 | 2020 |
| Deconvolution of WNT-induced Frizzled conformational dynamics with fluorescent biosensors H Schihada, M Kowalski-Jahn, A Turku, G Schulte Biosensors and Bioelectronics 177, 112948, 2021 | 32 | 2021 |
| Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity A Turku, MK Rinne, G Boije af Gennäs, H Xhaard, D Lindholm, ... PLoS One 12 (6), e0178526, 2017 | 31 | 2017 |
| A NanoBRET-based binding assay for smoothened allows real-time analysis of ligand binding and distinction of two binding sites for BODIPY-cyclopamine P Kozielewicz, CF Bowin, A Turku, G Schulte Molecular pharmacology 97 (1), 23-34, 2020 | 30 | 2020 |
| Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain M Kowalski-Jahn, H Schihada, A Turku, T Huber, TP Sakmar, G Schulte Science Advances 7 (46), eabj7917, 2021 | 29 | 2021 |
| Azulene-based compounds for targeting orexin receptors TO Leino, A Turku, J Yli-Kauhaluoma, JP Kukkonen, H Xhaard, ... European Journal of Medicinal Chemistry 157, 88-100, 2018 | 28 | 2018 |
| Residue 6.43 defines receptor function in class F GPCRs A Turku, H Schihada, P Kozielewicz, CF Bowin, G Schulte Nature Communications 12 (1), 3919, 2021 | 26 | 2021 |
| Insights into the mechanism of membrane pyrophosphatases by combining experiment and computer simulation NR Shah, C Wilkinson, SPD Harborne, A Turku, KM Li, YJ Sun, S Harris, ... Structural Dynamics 4 (3), 2017 | 26 | 2017 |
| Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine Y Zhou, GH Arribas, A Turku, T Jürgenson, S Mkrtchian, K Krebs, Y Wang, ... Science Advances 7 (36), eabi6856, 2021 | 25 | 2021 |
| Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands A Turku, A Borrel, TO Leino, L Karhu, JP Kukkonen, H Xhaard Journal of Medicinal Chemistry 59 (18), 8263-8275, 2016 | 25 | 2016 |
| Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor K Vidilaseris, A Kiriazis, A Turku, A Khattab, NG Johansson, TO Leino, ... Science Advances 5 (5), eaav7574, 2019 | 24 | 2019 |
| Modeling of the OX1R–orexin-A complex suggests two alternative binding modes L Karhu, A Turku, H Xhaard BMC structural biology 15, 1-17, 2015 | 22 | 2015 |
| Pharmacological characterization of the orexin/hypocretin receptor agonist Nag 26 MK Rinne, TO Leino, A Turku, PM Turunen, Y Steynen, H Xhaard, ... European Journal of Pharmacology 837, 137-144, 2018 | 17 | 2018 |
| Discovery of membrane-bound pyrophosphatase inhibitors derived from an isoxazole fragment NG Johansson, A Turku, K Vidilaseris, L Dreano, A Khattab, ... ACS Medicinal Chemistry Letters 11 (4), 605-610, 2020 | 15 | 2020 |
| Structure–Activity Relationships of 1‐Benzoylazulenes at the OX1 and OX2 Orexin Receptors A Turku, TO Leino, L Karhu, J Yli‐Kauhaluoma, JP Kukkonen, ... ChemMedChem 14 (9), 965-981, 2019 | 13 | 2019 |
| Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C R Provenzani, I Tarvainen, G Brandoli, A Lempinen, S Artes, A Turku, ... PLoS One 13 (4), e0195668, 2018 | 12 | 2018 |
| Defining dynamics of membrane-bound pyrophosphatases by experimental and computational single-molecule fret SPD Harborne, J Strauss, A Turku, MA Watson, R Tuma, SA Harris, ... Methods in Enzymology 607, 93-130, 2018 | 4 | 2018 |
| Screening for Thermotoga maritima Membrane-Bound Pyrophosphatase Inhibitors K Vidilaseris, NG Johansson, A Turku, A Kiriazis, GB af Gennäs, ... JoVE (Journal of Visualized Experiments), e60619, 2019 | 3 | 2019 |
