| pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures DEV Pires, TL Blundell, DB Ascher Journal of medicinal chemistry 58 (9), 4066-4072, 2015 | 4154 | 2015 |
| mCSM: predicting the effects of mutations in proteins using graph-based signatures DEV Pires, DB Ascher, TL Blundell Bioinformatics 30 (3), 335-342, 2014 | 1008 | 2014 |
| DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability CHM Rodrigues, DEV Pires, DB Ascher Nucleic acids research 46 (W1), W350-W355, 2018 | 965 | 2018 |
| DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach DEV Pires, DB Ascher, TL Blundell Nucleic acids research 42 (W1), W314-W319, 2014 | 886 | 2014 |
| A structural biology community assessment of AlphaFold2 applications M Akdel, DEV Pires, EP Pardo, J Jänes, AO Zalevsky, B Mészáros, ... Nature Structural & Molecular Biology 29 (11), 1056-1067, 2022 | 496 | 2022 |
| SDM: a server for predicting effects of mutations on protein stability AP Pandurangan, B Ochoa-Montano, DB Ascher, TL Blundell Nucleic acids research 45 (W1), W229-W235, 2017 | 487 | 2017 |
| Arpeggio: a web server for calculating and visualising interatomic interactions in protein structures HC Jubb, AP Higueruelo, B Ochoa-Montaño, WR Pitt, DB Ascher, ... Journal of molecular biology 429 (3), 365-371, 2017 | 434 | 2017 |
| DynaMut2: Assessing changes in stability and flexibility upon single and multiple point missense mutations CHM Rodrigues, DEV Pires, DB Ascher Protein Science 30 (1), 60-69, 2021 | 392 | 2021 |
| mCSM-PPI2: predicting the effects of mutations on protein–protein interactions CHM Rodrigues, Y Myung, DEV Pires, DB Ascher Nucleic acids research 47 (W1), W338-W344, 2019 | 323 | 2019 |
| Tumour risks and genotype–phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD KA Andrews, DB Ascher, DEV Pires, DR Barnes, L Vialard, RT Casey, ... Journal of medical genetics 55 (6), 384-394, 2018 | 241 | 2018 |
| Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam KE Holt, P McAdam, PVK Thai, NTT Thuong, DTM Ha, NN Lan, NH Lan, ... Nature genetics 50 (6), 849-856, 2018 | 196 | 2018 |
| Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation J Traynelis, M Silk, Q Wang, SF Berkovic, L Liu, DB Ascher, DJ Balding, ... Genome research 27 (10), 1715-1729, 2017 | 194 | 2017 |
| DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair BL Sibanda, DY Chirgadze, DB Ascher, TL Blundell Science 355 (6324), 520-524, 2017 | 186 | 2017 |
| Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health HC Jubb, AP Pandurangan, MA Turner, B Ochoa-Montaño, TL Blundell, ... Progress in biophysics and molecular biology 128, 3-13, 2017 | 179 | 2017 |
| Deep learning in diabetic foot ulcers detection: A comprehensive evaluation MH Yap, R Hachiuma, A Alavi, R Brüngel, B Cassidy, M Goyal, H Zhu, ... Computers in biology and medicine 135, 104596, 2021 | 159 | 2021 |
| Flexibility and small pockets at protein–protein interfaces: new insights into druggability H Jubb, TL Blundell, DB Ascher Progress in biophysics and molecular biology 119 (1), 2-9, 2015 | 151 | 2015 |
| Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker Scientific reports 4 (1), 4765, 2014 | 139 | 2014 |
| mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance DEV Pires, TL Blundell, DB Ascher Scientific reports 6 (1), 29575, 2016 | 136 | 2016 |
| mCSM-AB: a web server for predicting antibody–antigen affinity changes upon mutation with graph-based signatures DEV Pires, DB Ascher Nucleic acids research 44 (W1), W469-W473, 2016 | 129 | 2016 |
| Identification and characterization of a new cognitive enhancer based on inhibition of insulin‐regulated aminopeptidase AL Albiston, CJ Morton, HL Ng, V Pham, HR Yeatman, S Ye, ... The FASEB Journal 22 (12), 4209-4217, 2008 | 129 | 2008 |
Douglas PiresChief Data Officer, XymeVerified email at xyme.ai