The impact of sex on gene expression across human tissues M Oliva, M Muñoz-Aguirre, S Kim-Hellmuth, V Wucher, ADH Gewirtz, ... Science 369 (6509), eaba3066, 2020 | 863 | 2020 |
A quantitative proteome map of the human body L Jiang, M Wang, S Lin, R Jian, X Li, J Chan, G Dong, H Fang, ... Cell 183 (1), 269-283. e19, 2020 | 372 | 2020 |
Organ aging signatures in the plasma proteome track health and disease HSH Oh, J Rutledge, D Nachun, R Pálovics, O Abiose, P Moran-Losada, ... Nature 624 (7990), 164-172, 2023 | 193 | 2023 |
Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease OM de Goede, DC Nachun, NM Ferraro, MJ Gloudemans, AS Rao, ... Cell 184 (10), 2633-2648. e19, 2021 | 145 | 2021 |
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes D Nachun, AT Lu, AG Bick, P Natarajan, J Weinstock, MD Szeto, ... Aging Cell 20 (6), e13366, 2021 | 97 | 2021 |
Clonal hematopoiesis is associated with protection from Alzheimer’s disease H Bouzid, JA Belk, M Jan, Y Qi, C Sarnowski, S Wirth, L Ma, MR Chrostek, ... Nature Medicine 29 (7), 1662-1670, 2023 | 67 | 2023 |
DNA methylation analysis validates organoids as a viable model for studying human intestinal aging SK Lewis, D Nachun, MG Martin, S Horvath, G Coppola, DL Jones Cellular and molecular gastroenterology and hepatology 9 (3), 527-541, 2020 | 66 | 2020 |
Synaptic and gene regulatory mechanisms in schizophrenia, autism, and 22q11. 2 copy number variant–mediated risk for neuropsychiatric disorders JK Forsyth, D Nachun, MJ Gandal, DH Geschwind, AE Anderson, ... Biological psychiatry 87 (2), 150-163, 2020 | 56 | 2020 |
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease MM Uddin, NQH Nguyen, B Yu, JA Brody, A Pampana, T Nakao, ... Nature communications 13 (1), 5350, 2022 | 55 | 2022 |
Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich’s ataxia patients D Nachun, F Gao, C Isaacs, C Strawser, Z Yang, D Dokuru, V Van Berlo, ... Human molecular genetics 27 (17), 2965-2977, 2018 | 50 | 2018 |
Transcriptional profiling of isogenic Friedreich ataxia neurons and effect of an HDAC inhibitor on disease signatures JI Lai, D Nachun, L Petrosyan, B Throesch, E Campau, F Gao, ... Journal of Biological Chemistry 294 (6), 1846-1859, 2019 | 38 | 2019 |
Nonsense-mediated decay is highly stable across individuals and tissues NA Teran, DC Nachun, T Eulalio, NM Ferraro, C Smail, MA Rivas, ... The American Journal of Human Genetics 108 (8), 1401-1408, 2021 | 34 | 2021 |
Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes PJ Rauch, J Gopakumar, AJ Silver, D Nachun, H Ahmad, M McConkey, ... Nature Cardiovascular Research 2 (9), 805-818, 2023 | 27 | 2023 |
Progranulin levels in blood in Alzheimer's disease and mild cognitive impairment YA Cooper, D Nachun, D Dokuru, Z Yang, AM Karydas, G Serrero, B Yue, ... Annals of clinical and translational neurology 5 (5), 616-629, 2018 | 26 | 2018 |
The mitochondrial multi-omic response to exercise training across rat tissues D Amar, NR Gay, D Jimenez-Morales, PMJ Beltran, ME Ramaker, ... Cell Metabolism, 2024 | 24 | 2024 |
Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain AL Lang, T Eulalio, E Fox, K Yakabi, SA Bukhari, CH Kawas, MM Corrada, ... Acta Neuropathologica Communications 10 (1), 174, 2022 | 24 | 2022 |
GADD45A is a protective modifier of neurogenic skeletal muscle atrophy JT Ehmsen, R Kawaguchi, D Kaval, AE Johnson, D Nachun, G Coppola, ... Jci Insight 6 (13), 2021 | 22 | 2021 |
Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes MJ Gloudemans, B Balliu, D Nachun, TM Schnurr, MG Durrant, ... Genome medicine 14 (1), 31, 2022 | 21 | 2022 |
PRC2 clock: a universal epigenetic biomarker of aging and rejuvenation M Moqri, A Cipriano, D Nachun, T Murty, G de Sena Brandine, S Rasouli, ... BioRxiv, 2022.06. 03.494609, 2022 | 19 | 2022 |
Temporal dynamics of the multi-omic response to endurance exercise training across tissues MoTrPAC Study Group, D Amar, NR Gay, PM Jean Beltran, JN Adkins, ... BioRxiv, 2022.09. 21.508770, 2022 | 16 | 2022 |