| Anticancer activities of histone deacetylase inhibitors JE Bolden, MJ Peart, RW Johnstone Nature reviews Drug discovery 5 (9), 769-784, 2006 | 3625 | 2006 |
| Apoptosis: a link between cancer genetics and chemotherapy RW Johnstone, AA Ruefli, SW Lowe Cell 108 (2), 153-164, 2002 | 3111 | 2002 |
| Histone-deacetylase inhibitors: novel drugs for the treatment of cancer RW Johnstone Nature reviews Drug discovery 1 (4), 287-299, 2002 | 2063 | 2002 |
| Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders KJ Falkenberg, RW Johnstone Nature reviews Drug discovery 13 (9), 673-691, 2014 | 1751 | 2014 |
| New and emerging HDAC inhibitors for cancer treatment AC West, RW Johnstone The Journal of clinical investigation 124 (1), 30-39, 2014 | 1598 | 2014 |
| The TRAIL apoptotic pathway in cancer onset, progression and therapy RW Johnstone, AJ Frew, MJ Smyth Nature Reviews Cancer 8 (10), 782-798, 2008 | 1020 | 2008 |
| Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis M Nguyen, RC Marcellus, A Roulston, M Watson, L Serfass, ... Proceedings of the National Academy of Sciences 104 (49), 19512-19517, 2007 | 832 | 2007 |
| Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors MJ Peart, GK Smyth, RK Van Laar, DD Bowtell, VM Richon, PA Marks, ... Proceedings of the National Academy of Sciences 102 (10), 3697-3702, 2005 | 677 | 2005 |
| The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production … AA Ruefli, MJ Ausserlechner, D Bernhard, VR Sutton, KM Tainton, ... Proceedings of the National Academy of Sciences 98 (19), 10833-10838, 2001 | 634 | 2001 |
| Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? RW Johnstone, JD Licht Cancer cell 4 (1), 13-18, 2003 | 626 | 2003 |
| Epigenetics in cancer: targeting chromatin modifications L Ellis, PW Atadja, RW Johnstone Molecular cancer therapeutics 8 (6), 1409-1420, 2009 | 622 | 2009 |
| Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor T Jin, A Perry, J Jiang, P Smith, JA Curry, L Unterholzner, Z Jiang, ... Immunity 36 (4), 561-571, 2012 | 620 | 2012 |
| Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53 MJ Bywater, G Poortinga, E Sanij, N Hein, A Peck, C Cullinane, M Wall, ... Cancer cell 22 (1), 51-65, 2012 | 603 | 2012 |
| Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy JH Elliott, F Wightman, A Solomon, K Ghneim, J Ahlers, MJ Cameron, ... PLoS pathogens 10 (11), e1004473, 2014 | 577 | 2014 |
| BET inhibitor resistance emerges from leukaemia stem cells CY Fong, O Gilan, EYN Lam, AF Rubin, S Ftouni, D Tyler, K Stanley, ... Nature 525 (7570), 538-542, 2015 | 543 | 2015 |
| Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B–mediated caspase activation VR Sutton, JE Davis, M Cancilla, RW Johnstone, AA Ruefli, K Sedelies, ... The Journal of experimental medicine 192 (10), 1403-1414, 2000 | 528 | 2000 |
| Constitutive type I interferon modulates homeostatic balance through tonic signaling DJ Gough, NL Messina, CJP Clarke, RW Johnstone, DE Levy Immunity 36 (2), 166-174, 2012 | 520 | 2012 |
| Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ... Nature communications 9 (1), 5341, 2018 | 503 | 2018 |
| Multiple physiological functions for multidrug transporter P-glycoprotein? RW Johnstone, AA Ruefli, MJ Smyth Trends in biochemical sciences 25 (1), 1-6, 2000 | 495 | 2000 |
| The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis MJ Smyth, E Krasovskis, VR Sutton, RW Johnstone Proceedings of the National Academy of Sciences 95 (12), 7024-7029, 1998 | 468 | 1998 |