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| Structure of the FKBP12-rapamycin complex interacting with binding domain of human FRAP J Choi, J Chen, SL Schreiber, J Clardy Science 273 (5272), 239-242, 1996 | 1169 | 1996 |
| Control of p70 S6 kinase by kinase activity of FRAP in vivo EJ Brown, PA Beal, CT Keith, J Chen, T Bum Shin, SL Schreiber Nature 377 (6548), 441-446, 1995 | 909 | 1995 |
| Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. J Chen, X Zheng, EJ Brown, SL Schreiber Proceedings of the National Academy of Sciences 92 (11), 4947-4951, 1995 | 814 | 1995 |
| Regulation of peroxisome proliferator–activated receptor-γ activity by mammalian target of rapamycin and amino acids in adipogenesis JE Kim, J Chen Diabetes 53 (11), 2748-2756, 2004 | 501 | 2004 |
| Probing cellular protein complexes using single-molecule pull-down A Jain, R Liu, B Ramani, E Arauz, Y Ishitsuka, K Ragunathan, J Park, ... Nature 473 (7348), 484-488, 2011 | 476 | 2011 |
| TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin XF Zheng, D Fiorentino, J Chen, GR Crabtree, SL Schreiber Cell 82 (1), 121-130, 1995 | 384 | 1995 |
| Interleukin‐6 and insulin resistance JH Kim, RA Bachmann, J Chen Vitamins & Hormones 80, 613-633, 2009 | 346 | 2009 |
| IGF-II is regulated by microRNA-125b in skeletal myogenesis Y Ge, Y Sun, J Chen Journal of Cell Biology 192 (1), 69-81, 2011 | 291 | 2011 |
| Cytoplasmic–nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation JE Kim, J Chen Proceedings of the National Academy of Sciences 97 (26), 14340-14345, 2000 | 269 | 2000 |
| mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells J Zhou, P Su, L Wang, J Chen, M Zimmermann, O Genbacev, O Afonja, ... Proceedings of the national academy of sciences 106 (19), 7840-7845, 2009 | 242 | 2009 |
| Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis Y Sun, Y Ge, J Drnevich, Y Zhao, M Band, J Chen Journal of Cell Biology 189 (7), 1157-1169, 2010 | 236 | 2010 |
| (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest DT Hung, J Chen, SL Schreiber Chemistry & biology 3 (4), 287-293, 1996 | 236 | 1996 |
| α4 associates with protein phosphatases 2A, 4, and 6 J Chen, RT Peterson, SL Schreiber Biochemical and biophysical research communications 247 (3), 827-832, 1998 | 232 | 1998 |
| Phospholipase D1 is an effector of Rheb in the mTOR pathway Y Sun, Y Fang, MS Yoon, C Zhang, M Roccio, FJ Zwartkruis, M Armstrong, ... Proceedings of the National Academy of Sciences 105 (24), 8286-8291, 2008 | 231 | 2008 |
| PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1 Y Fang, IH Park, AL Wu, G Du, P Huang, MA Frohman, SJ Walker, ... Current biology 13 (23), 2037-2044, 2003 | 223 | 2003 |
| IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients E Erbay, IH Park, PD Nuzzi, CJ Schoenherr, J Chen The Journal of cell biology 163 (5), 931-936, 2003 | 216 | 2003 |
| The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression M Vilella-Bach, P Nuzzi, Y Fang, J Chen Journal of Biological Chemistry 274 (7), 4266-4272, 1999 | 209 | 1999 |
| Duration of rapamycin treatment has differential effects on metabolism in mice Y Fang, R Westbrook, C Hill, RK Boparai, O Arum, A Spong, F Wang, ... Cell metabolism 17 (3), 456-462, 2013 | 206 | 2013 |
| Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization M Simons, WJ Gault, D Gotthardt, R Rohatgi, TJ Klein, Y Shao, HJ Lee, ... Nature cell biology 11 (3), 286-294, 2009 | 204 | 2009 |
