| Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity AL Kaplan, DN Confair, K Kim, X Barros-Álvarez, RM Rodriguiz, Y Yang, ... Nature 610 (7932), 582-591, 2022 | 178 | 2022 |
| G-protein activation by a metabotropic glutamate receptor AB Seven, X Barros-Álvarez, M de Lapeyrière, MM Papasergi-Scott, ... Nature 595 (7867), 450-454, 2021 | 115 | 2021 |
| The tethered peptide activation mechanism of adhesion GPCRs X Barros-Álvarez, RM Nwokonko, A Vizurraga, D Matzov, F He, ... Nature 604 (7907), 757-762, 2022 | 97 | 2022 |
| Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD C Cao, X Barros-Álvarez, S Zhang, K Kim, MA Dämgen, O Panova, ... Neuron 110 (19), 3154-3167. e7, 2022 | 94 | 2022 |
| Glycosomal targets for anti-trypanosomatid drug discovery X Barros-Alvarez, M Gualdron-Lopez, H Acosta, AJ Caceres, ... Current medicinal chemistry 21 (15), 1679-1706, 2014 | 52 | 2014 |
| The oxytocin signaling complex reveals a molecular switch for cation dependence JG Meyerowitz, MJ Robertson, X Barros-Álvarez, O Panova, ... Nature Structural & Molecular Biology 29 (3), 274-281, 2022 | 46 | 2022 |
| AlphaFold2 structures guide prospective ligand discovery J Lyu, N Kapolka, R Gumpper, A Alon, L Wang, MK Jain, X Barros-Álvarez, ... Science, eadn6354, 2024 | 42 | 2024 |
| Development of methionyl-tRNA synthetase inhibitors as antibiotics for Gram-positive bacterial infections O Faghih, Z Zhang, RM Ranade, JR Gillespie, SA Creason, W Huang, ... Antimicrobial Agents and Chemotherapy 61 (11), 10.1128/aac. 00999-17, 2017 | 35 | 2017 |
| Leishmania mexicana: LACK (Leishmania homolog of receptors for activated C-kinase) is a plasminogen binding protein A Gómez-Arreaza, H Acosta, X Barros-Álvarez, JL Concepción, ... Experimental parasitology 127 (4), 752-761, 2011 | 31 | 2011 |
| Structure-guided design of novel Trypanosoma brucei methionyl-tRNA synthetase inhibitors W Huang, Z Zhang, X Barros-Álvarez, CY Koh, RM Ranade, JR Gillespie, ... European journal of medicinal chemistry 124, 1081-1092, 2016 | 30 | 2016 |
| From cells to mice to target: characterization of NEU-1053 (SB-443342) and its analogues for treatment of human African trypanosomiasis WG Devine, R Diaz-Gonzalez, G Ceballos-Perez, D Rojas, T Satoh, ... ACS infectious diseases 3 (3), 225-236, 2017 | 29 | 2017 |
| The phosphoglycerate kinase isoenzymes have distinct roles in the regulation of carbohydrate metabolism in Trypanosoma cruzi X Barros-Álvarez, AJ Cáceres, PAM Michels, JL Concepción, W Quiñones Experimental parasitology 143, 39-47, 2014 | 20 | 2014 |
| Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts X Barros-Álvarez, KM Kerchner, CY Koh, S Turley, E Pardon, J Steyaert, ... Biochimie 138, 124-136, 2017 | 17 | 2017 |
| Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors W Huang, Z Zhang, RM Ranade, JR Gillespie, X Barros-Álvarez, ... Bioorganic & medicinal chemistry letters 27 (12), 2702-2707, 2017 | 16 | 2017 |
| The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate X Barros-Alvarez, S Turley, RM Ranade, JR Gillespie, NA Duster, ... Acta Crystallographica Section F: Structural Biology Communications 74 (4 …, 2018 | 15 | 2018 |
| AlphaFold2 structures template ligand discovery J Lyu, N Kapolka, R Gumpper, A Alon, L Wang, MK Jain, X Barros-Álvarez, ... BioRxiv, 2023.12. 20.572662, 2024 | 11 | 2024 |
| Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei Z Zhang, X Barros-Álvarez, JR Gillespie, RM Ranade, W Huang, ... RSC Medicinal Chemistry 11 (8), 885-895, 2020 | 11 | 2020 |
| The glycosomal-membrane associated phosphoglycerate kinase isoenzyme A plays a role in sustaining the glucose flux in Trypanosoma cruzi epimastigotes X Barros-Álvarez, AJ Cáceres, MT Ruiz, PAM Michels, JL Concepción, ... Molecular and Biochemical Parasitology 200 (1-2), 5-8, 2015 | 7 | 2015 |
| Aminoacyl-tRNA Synthetases as Targets for Structure Guided Drug Design (SGDD) Against Pathogenic Protozoa and Bacteria X Barros Alvarez | 1 | 2018 |
| Signaling Snapshots of 5-HT 2BR Activated by the Prototypical Psychedelic LSD C Cao, X Barros-Álvarez, S Zhang, K Kim, MA Dämgen, O Panova, ... | 1 | |
Christophe LMJ VerlindeAssociate professor of Biochemistry, University of Washington, SeattleVerified email at u.washington.edu