| TLR signalling augments macrophage bactericidal activity through mitochondrial ROS AP West, IE Brodsky, C Rahner, DK Woo, H Erdjument-Bromage, ... Nature 472 (7344), 476-480, 2011 | 1770 | 2011 |
| Mitochondrial DNA stress primes the antiviral innate immune response P West Biophysical Journal 108 (2), 3a, 2015 | 1665 | 2015 |
| NF-κB and the immune response MS Hayden, AP West, S Ghosh Oncogene 25 (51), 6758-6780, 2006 | 1619 | 2006 |
| Mitochondria in innate immune responses AP West, GS Shadel, S Ghosh Nature Reviews Immunology 11 (6), 389-402, 2011 | 1514 | 2011 |
| Recognition and signaling by toll-like receptors AP West, AA Koblansky, S Ghosh Annu. Rev. Cell Dev. Biol. 22 (1), 409-437, 2006 | 969 | 2006 |
| Mitochondrial DNA in innate immune responses and inflammatory pathology AP West, GS Shadel Nature Reviews Immunology 17 (6), 363-375, 2017 | 918 | 2017 |
| Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA A Rongvaux, R Jackson, CCD Harman, T Li, AP West, MR De Zoete, ... Cell 159 (7), 1563-1577, 2014 | 806 | 2014 |
| A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1 B Zhao, F Du, P Xu, C Shu, B Sankaran, SL Bell, M Liu, Y Lei, X Gao, X Fu, ... Nature 569 (7758), 718-722, 2019 | 338 | 2019 |
| Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes SB Mizel, AN Honko, MA Moors, PS Smith, AP West The Journal of Immunology 170 (12), 6217-6223, 2003 | 266 | 2003 |
| cGAS drives noncanonical-inflammasome activation in age-related macular degeneration N Kerur, S Fukuda, D Banerjee, Y Kim, D Fu, I Apicella, A Varshney, ... Nature medicine 24 (1), 50-61, 2018 | 257 | 2018 |
| IκBβ acts to inhibit and activate gene expression during the inflammatory response P Rao, MS Hayden, M Long, ML Scott, AP West, D Zhang, A Oeckinghaus, ... Nature 466 (7310), 1115-1119, 2010 | 225 | 2010 |
| Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis CG Weindel, EL Martinez, X Zhao, CJ Mabry, SL Bell, KJ Vail, ... Cell 185 (17), 3214-3231. e23, 2022 | 210 | 2022 |
| The molecular basis of tight nuclear tethering and inactivation of cGAS B Zhao, P Xu, CM Rowlett, T Jing, O Shinde, Y Lei, AP West, WR Liu, P Li Nature 587 (7835), 673-677, 2020 | 206 | 2020 |
| Mitochondrial dysfunction as a trigger of innate immune responses and inflammation AP West Toxicology 391, 54-63, 2017 | 194 | 2017 |
| Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo KF Yambire, C Rostosky, T Watanabe, D Pacheu-Grau, S Torres-Odio, ... Elife 8, e51031, 2019 | 193 | 2019 |
| Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin SB Mizel, AP West, RR Hantgan Journal of Biological Chemistry 278 (26), 23624-23629, 2003 | 188 | 2003 |
| Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL D Sengupta, A Koblansky, J Gaines, T Brown, AP West, D Zhang, ... The journal of immunology 184 (2), 956-964, 2010 | 154 | 2010 |
| Mitochondrial DNA stress signalling protects the nuclear genome Z Wu, S Oeck, AP West, KC Mangalhara, AG Sainz, LE Newman, ... Nature metabolism 1 (12), 1209-1218, 2019 | 115 | 2019 |
| Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity Y Lei, JJ VanPortfliet, YF Chen, JD Bryant, Y Li, D Fails, S Torres-Odio, ... Cell 186 (14), 3013-3032. e22, 2023 | 106 | 2023 |
| MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury P Mannam, AS Shinn, A Srivastava, RF Neamu, WE Walker, M Bohanon, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 306 (7 …, 2014 | 102 | 2014 |
Gerald S. ShadelProfessor, Salk Institute for Biological StudiesVerified email at salk.edu