| Basic concepts in population modeling, simulation, and model-based drug development. D Mould, R Upton Clinical Pharmacology and Therapeutics - Pharmacometrics and Systems …, 2012 | 1200* | 2012 |
| Food, gastrointestinal pH, and models of oral drug absorption AY Abuhelwa, DB Williams, RN Upton, DJR Foster European journal of pharmaceutics and biopharmaceutics 112, 234-248, 2017 | 316 | 2017 |
| Basic concepts in population modeling, simulation, and model‐based drug development: part 3—introduction to pharmacodynamic modeling methods RN Upton, DR Mould CPT: pharmacometrics & systems pharmacology 3 (1), 1-16, 2014 | 307 | 2014 |
| Cardiac output is a determinant of the initial concentrations of propofol after short-infusion administration RN Upton, GL Ludbrook, C Grant, AM Martinez Anesthesia & Analgesia 89 (3), 545, 1999 | 213 | 1999 |
| Reduced intrathoracic blood volume and left and right ventricular dimensions in patients with severe emphysema: an MRI study K Jörgensen, MF Müller, J Nel, RN Upton, E Houltz, SE Ricksten Chest 131 (4), 1050-1057, 2007 | 194 | 2007 |
| Hemodynamic and central nervous system effects of intravenous bolus doses of lidocaine, bupivacaine, and ropivacaine in sheep AJ Rutten, C Nancarrow, LE Mather, AH Ilsley, WB Runciman, RN Upton Anesthesia & Analgesia 69 (3), 291-299, 1989 | 187 | 1989 |
| The Performance of Compartmental and Physiologically Based Recirculatory Pharmacokinetic Models for Propofol: A Comparison Using Bolus, Continuous, and Target-Controlled … K Masui, RN Upton, AG Doufas, JF Coetzee, T Kazama, EP Mortier, ... Anesthesia and Analgesia 111 (2), 2010 | 172 | 2010 |
| Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized … LL Christrup, D Foster, LD Popper, T Troen, R Upton Clinical therapeutics 30 (3), 469-481, 2008 | 161 | 2008 |
| Pharmacokinetic optimisation of opioid treatment in acute pain therapy RN Upton, TJ Semple, PE Macintyre Clinical pharmacokinetics 33, 225-244, 1997 | 148 | 1997 |
| Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery D Foster, R Upton, L Christrup, L Popper Annals of Pharmacotherapy 42 (10), 1380-1387, 2008 | 129 | 2008 |
| A quantitative review and meta-models of the variability and factors affecting oral drug absorption—part I: gastrointestinal pH AY Abuhelwa, DJR Foster, RN Upton The AAPS journal 18, 1309-1321, 2016 | 115 | 2016 |
| Population pharmacokinetic modeling of itraconazole and hydroxyitraconazole for oral SUBA-itraconazole and sporanox capsule formulations in healthy subjects in fed and fasted … AY Abuhelwa, DJR Foster, S Mudge, D Hayes, RN Upton Antimicrobial agents and chemotherapy 59 (9), 5681-5696, 2015 | 108 | 2015 |
| Epinephrine, norepinephrine and dopamine infusions decrease propofol concentrations during continuous propofol infusion in an ovine model JA Myburgh, RN Upton, C Grant, A Martinez Intensive Care Medicine 27, 276-282, 2001 | 105 | 2001 |
| Interactive pharmacometric applications using R and the shiny package J Wojciechowski, AM Hopkins, RN Upton CPT: pharmacometrics & systems pharmacology 4 (3), 146-159, 2015 | 104 | 2015 |
| Organ weights and blood flows of sheep and pig for physiological pharmacokinetic modelling RN Upton Journal of pharmacological and toxicological methods 58 (3), 198-205, 2008 | 104 | 2008 |
| A physiological model of induction of anaesthesia with propofol in sheep. 2. Model analysis and implications for dose requirements. GL Ludbrook, RN Upton British journal of anaesthesia 79 (4), 505-513, 1997 | 96 | 1997 |
| Clinical decision support tools: the evolution of a revolution DR Mould, G D'haens, RN Upton Clinical Pharmacology & Therapeutics 99 (4), 405-418, 2016 | 88 | 2016 |
| A physiologically based, recirculatory model of the kinetics and dynamics of propofol in man RN Upton, G Ludbrook Anesthesiology 103 (2), 344-352, 2005 | 83 | 2005 |
| A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variables RN Upton, GL Ludbrook British journal of anaesthesia 79 (4), 497-504, 1997 | 82 | 1997 |
| A quantitative review and meta-models of the variability and factors affecting oral drug absorption—part II: gastrointestinal transit time AY Abuhelwa, DJR Foster, RN Upton The AAPS journal 18, 1322-1333, 2016 | 81 | 2016 |
Cliff GrantUniversity of AdelaideVerified email at adelaide.edu.au