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Amanda R. Moore
Amanda R. Moore
Unknown affiliation
Verified email at gene.com
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Year
RAS-targeted therapies: is the undruggable drugged?
AR Moore, SC Rosenberg, F McCormick, S Malek
Nature reviews Drug discovery 19 (8), 533-552, 2020
9372020
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma
AR Moore, E Ceraudo, JJ Sher, Y Guan, AN Shoushtari, MT Chang, ...
Nature genetics 48 (6), 675-680, 2016
3412016
Spliceosomal disruption of the non-canonical BAF complex in cancer
D Inoue, GL Chew, B Liu, BC Michel, J Pangallo, AR D’Avino, T Hitchman, ...
Nature 574 (7778), 432-436, 2019
2102019
ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma
I Yen, F Shanahan, J Lee, YS Hong, SJ Shin, AR Moore, J Sudhamsu, ...
Nature 594 (7863), 418-423, 2021
932021
GNA11 Q209L mouse model reveals RasGRP3 as an essential signaling node in uveal melanoma
AR Moore, L Ran, Y Guan, JJ Sher, TD Hitchman, JQ Zhang, C Hwang, ...
Cell reports 22 (9), 2455-2468, 2018
882018
Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma
TD Hitchman, G Bayshtok, E Ceraudo, AR Moore, C Lee, R Jia, N Wang, ...
Clinical Cancer Research 27 (5), 1476-1490, 2021
452021
Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling
E Ceraudo, M Horioka, JM Mattheisen, TD Hitchman, AR Moore, ...
Journal of Biological Chemistry 296, 2021
382021
A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon
D Gao, Y Zhan, W Di, AR Moore, JJ Sher, Y Guan, S Wang, Z Zhang, ...
PLoS One 11 (8), e0161084, 2016
262016
Author Correction: RAS-targeted therapies: is the undruggable drugged?
AR Moore, SC Rosenberg, F McCormick, S Malek
Nature Reviews Drug Discovery 19 (12), 902-902, 2020
202020
The promise and peril of KRAS G12C inhibitors
AR Moore, S Malek
Cancer Cell 39 (8), 1059-1061, 2021
182021
ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer
D Li, Y Zhan, N Wang, F Tang, CJ Lee, G Bayshtok, AR Moore, ...
Science Advances 9 (14), eadc9446, 2023
102023
Uveal Melanoma Oncogene CYSLTR2 Encodes a Constitutively Active GPCR Highly Biased Toward Gq Signaling
E Ceraudo, M Horioka, JM Mattheisen, TD Hitchman, AR Moore, ...
BioRxiv, 663153, 2019
102019
RAS-targeted therapies
AR Moore, SC Rosenberg, F McCormick, S Malek
Nature Reviews Drug Discovery, 1-1, 2021
12021
Abstract A039: RAS signaling strength determines phenotypic response in the colon
AR Moore, SM Carlos, EE Storm, LM McGinnis, S Malek, FJ de Sauvage
Molecular Cancer Research 21 (5_Supplement), A039-A039, 2023
2023
RAS-mutant mouse models confirm tissue-specificity and reveal unique oncogenic activity of KrasQ61R
AR Moore, J Liang, R Piskol, L McGinnis, DS Kirkpatrick, S Malek
Cancer Research 81 (13_Supplement), 2923-2923, 2021
2021
RAS-targeted therapies: is the undruggable drugged?(vol 19, pg 533, 2020)
AR Moore, SC Rosenberg, F McCormick, S Malek
Nature Reviews Drug Discovery 19 (12), 902-902, 2020
2020
Abstract A07: Activating mutations in uveal melanoma convey sensitivity to g-alpha q inhibition
TD Hitchman, E Ceraudo, AR Moore, AN Shoushtari, JH Francis, Y Guan, ...
Cancer Research 80 (19_Supplement), A07-A07, 2020
2020
Activating mutations in uveal melanoma convey sensitivity to g-alpha q inhibition.
TD Hitchman, E Ceraudo, AR Moore, AN Shoushtari, JH Francis, Y Guan, ...
CANCER RESEARCH 80 (19), 35-35, 2020
2020
Nongenomic BAP1 aberrancy drives highly aggressive cutaneous melanoma phenotype.
H Zhu, J Oba, X Yu, CA Creasy, MA Forget, F Carapeto, CL Haymaker, ...
CANCER RESEARCH 80 (19), 24-25, 2020
2020
Abstract PR03: Nongenomic BAP1 aberrancy drives highly aggressive cutaneous melanoma phenotype
H Zhu, J Oba, X Yu, CA Creasy, MA Forget, F Carapeto, CL Haymaker, ...
Cancer Research 80 (19_Supplement), PR03-PR03, 2020
2020
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