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Thomas Cotton
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Activation mechanism of PINK1
ZY Gan, S Callegari, SA Cobbold, TR Cotton, MJ Mlodzianoski, ...
Nature 602 (7896), 328-335, 2022
1302022
Structure of the human myostatin precursor and determinants of growth factor latency
TR Cotton, G Fischer, X Wang, JC McCoy, M Czepnik, TB Thompson, ...
The EMBO Journal 37 (3), 367-383, 2018
652018
Chain reactions: molecular mechanisms of RBR ubiquitin ligases
TR Cotton, BC Lechtenberg
Biochemical Society Transactions 48 (4), 1737-1750, 2020
602020
Molecular characterization of latent GDF8 reveals mechanisms of activation
RG Walker, JC McCoy, M Czepnik, MJ Mills, A Hagg, KL Walton, ...
Proceedings of the National Academy of Sciences 115 (5), E866-E875, 2018
402018
The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family
XS Wang, TR Cotton, SJ Trevelyan, LW Richardson, WT Lee, J Silke, ...
Nature Communications 14 (1), 168, 2023
392023
Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216
TR Cotton, SA Cobbold, JP Bernardini, LW Richardson, XS Wang, ...
Molecular cell 82 (3), 598-615. e8, 2022
262022
Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling
MJ Roy, MG Surudoi, A Kropp, J Hou, W Dai, JM Hardy, LY Liang, ...
Nature Communications 14 (1), 3542, 2023
102023
The role of sialic acid synthases in sialic acid biosynthesis
T Cotton, E Parker, D Joseph
Chemistry in New Zealand 78 (2), 69-74, 2014
52014
Probing the determinants of phosphorylated sugar-substrate binding for human sialic acid synthase
TR Cotton, DDA Joseph, W Jiao, EJ Parker
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844 (12), 2257-2264, 2014
32014
Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’signalling axis in triple negative breast cancer
X Yang, X Ma, T Zhao, DR Croucher, EV Nguyen, KC Clark, C Hu, ...
bioRxiv, 2024.02. 14.580406, 2024
12024
The structure of human pro-myostatin and molecular basis of latency
TR Cotton
12019
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