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Megha Aggarwal
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Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation
R Abdella, M Aggarwal, T Okura, RA Lamb, Y He
Proceedings of the National Academy of Sciences 117 (9), 4931-4941, 2020
1022020
4′-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication
J Sourimant, CM Lieber, M Aggarwal, RM Cox, JD Wolf, JJ Yoon, M Toots, ...
Science 375 (6577), 161-167, 2022
822022
Evaluation of antiviral activity of piperazine against Chikungunya virus targeting hydrophobic pocket of alphavirus capsid protein
M Aggarwal, R Kaur, A Saha, R Mudgal, R Yadav, PK Dash, M Parida, ...
Antiviral Research 146, 102-111, 2017
622017
Kinetic characterization of trans-proteolytic activity of Chikungunya virus capsid protease and development of a FRET-based HTS assay
M Aggarwal, R Sharma, P Kumar, M Parida, S Tomar
Scientific reports 5 (1), 14753, 2015
532015
Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein in complex with an amino-terminal peptide of the phosphoprotein
M Aggarwal, GP Leser, CA Kors, RA Lamb
Journal of virology 92 (5), 10.1128/jvi. 01304-17, 2018
402018
Repurposing papaverine as an antiviral agent against influenza viruses and paramyxoviruses
M Aggarwal, GP Leser, RA Lamb
Journal of virology 94 (6), 10.1128/jvi. 01888-19, 2020
352020
trans-Protease Activity and Structural Insights into the Active Form of the Alphavirus Capsid Protease
M Aggarwal, S Dhindwal, P Kumar, RJ Kuhn, S Tomar
Journal of Virology 88 (21), 12242-12253, 2014
342014
Crystal structure of aura virus capsid protease and its complex with dioxane: new insights into capsid-glycoprotein molecular contacts
M Aggarwal, S Tapas, Preeti, A Siwach, P Kumar, RJ Kuhn, S Tomar
PLoS One 7 (12), e51288, 2012
312012
Progress and pitfalls of a year of drug repurposing screens against COVID-19
J Sourimant, M Aggarwal, RK Plemper
Current Opinion in Virology 49, 183-193, 2021
292021
Structural insight into paramyxovirus and pneumovirus entry inhibition
M Aggarwal, RK Plemper
Viruses 12 (3), 342, 2020
162020
Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1
R Mudgal, C Bharadwaj, A Dubey, S Choudhary, P Nagarajan, ...
Antimicrobial Agents and Chemotherapy 66 (3), e01943-21, 2022
152022
4’-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses
CM Lieber, M Aggarwal, JJ Yoon, RM Cox, HJ Kang, J Sourimant, ...
Plos Pathogens 19 (4), e1011342, 2023
122023
Resveratrol inhibits Venezuelan equine encephalitis virus infection by interfering with the AKT/GSK pathway
CW Lehman, K Kehn-Hall, M Aggarwal, NR Bracci, HC Pan, L Panny, ...
Plants 10 (2), 346, 2021
72021
Crystallization, high-resolution data collection and preliminary crystallographic analysis of Aura virus capsid protease and its complex with dioxane
M Aggarwal, S Dhindwal, S Pratap, RJ Kuhn, P Kumar, S Tomar
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2011
62011
Structure and Function of Alphavirus Proteases
S Tomar, M Aggarwal
Viral Proteases and Their Inhibitors., 105-136, 2017
52017
Influenza A virus resistance to 4’-fluorouridine coincides with viral attenuation in vitro and in vivo
CM Lieber, HJ Kang, M Aggarwal, NA Lieberman, EB Sobolik, JJ Yoon, ...
Plos Pathogens 20 (2), e1011993, 2024
42024
4’-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication
J Sourimant, CM Lieber, M Aggarwal, RM Cox, JD Wolf, JJ Yoon, M Toots, ...
bioRxiv, 2021.05. 19.444875, 2021
42021
In silico and proteomic analysis of protein methyltransferase CheR from Bacillus subtilis
M Batra, R Sharma, V Chandra, M Aggarwal, U Agarwal, P Gupta, ...
International journal of biological macromolecules 77, 168-180, 2015
42015
Respiratory syncytial virus disease burden and nirsevimab effectiveness in young children from 2023-2024
HL Moline, AP Toepfer, A Tannis, GA Weinberg, MA Staat, NB Halasa, ...
JAMA pediatrics 179 (2), 179-187, 2025
2025
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Articles 1–19