Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart X Fu, H Khalil, O Kanisicak, JG Boyer, RJ Vagnozzi, BD Maliken, ... The Journal of clinical investigation 128 (5), 2127-2143, 2018 | 583 | 2018 |
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling T Oka, J Xu, RA Kaiser, J Melendez, M Hambleton, MA Sargent, A Lorts, ... Circulation research 101 (3), 313-321, 2007 | 568 | 2007 |
An acute immune response underlies the benefit of cardiac stem cell therapy RJ Vagnozzi, M Maillet, MA Sargent, H Khalil, AKZ Johansen, ... Nature 577 (7790), 405-409, 2020 | 521 | 2020 |
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy DP Millay, MA Sargent, H Osinska, CP Baines, ER Barton, G Vuagniaux, ... Nature medicine 14 (4), 442-447, 2008 | 425 | 2008 |
The mitochondrial calcium uniporter selectively matches metabolic output to acute contractile stress in the heart JQ Kwong, X Lu, RN Correll, JA Schwanekamp, RJ Vagnozzi, MA Sargent, ... Cell reports 12 (1), 15-22, 2015 | 379 | 2015 |
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice J Karch, JQ Kwong, AR Burr, MA Sargent, JW Elrod, PM Peixoto, ... elife 2, e00772, 2013 | 327 | 2013 |
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart J Heineke, M Auger-Messier, J Xu, T Oka, MA Sargent, A York, R Klevitsky, ... The Journal of clinical investigation 117 (11), 3198-3210, 2007 | 296 | 2007 |
Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure J Heineke, M Auger-Messier, J Xu, M Sargent, A York, S Welle, ... Circulation 121 (3), 419-425, 2010 | 295 | 2010 |
Fibroblast-specific genetic manipulation of p38 mitogen-activated protein kinase in vivo reveals its central regulatory role in fibrosis JD Molkentin, D Bugg, N Ghearing, LE Dorn, P Kim, MA Sargent, ... Circulation 136 (6), 549-561, 2017 | 288 | 2017 |
Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism DP Millay, SA Goonasekera, MA Sargent, M Maillet, BJ Aronow, ... Proceedings of the National Academy of Sciences 106 (45), 19023-19028, 2009 | 263 | 2009 |
Inhibiting fibronectin attenuates fibrosis and improves cardiac function in a model of heart failure I Valiente-Alandi, SJ Potter, AM Salvador, AE Schafer, T Schips, ... Circulation 138 (12), 1236-1252, 2018 | 261 | 2018 |
Cardiac myosin binding protein C phosphorylation is cardioprotective S Sadayappan, H Osinska, R Klevitsky, JN Lorenz, M Sargent, ... Proceedings of the National Academy of Sciences 103 (45), 16918-16923, 2006 | 250 | 2006 |
A thrombospondin-dependent pathway for a protective ER stress response JM Lynch, M Maillet, D Vanhoutte, A Schloemer, MA Sargent, NS Blair, ... Cell 149 (6), 1257-1268, 2012 | 239 | 2012 |
Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle SA Goonasekera, CK Lam, DP Millay, MA Sargent, RJ Hajjar, EG Kranias, ... The Journal of clinical investigation 121 (3), 1044-1052, 2011 | 232 | 2011 |
Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD J Karch, MJ Bround, H Khalil, MA Sargent, N Latchman, N Terada, ... Science advances 5 (8), eaaw4597, 2019 | 218 | 2019 |
DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility M Maillet, NH Purcell, MA Sargent, AJ York, OF Bueno, JD Molkentin Journal of Biological Chemistry 283 (45), 31246-31255, 2008 | 215 | 2008 |
Decreased cardiac L-type Ca2+ channel activity induces hypertrophy and heart failure in mice SA Goonasekera, K Hammer, M Auger-Messier, I Bodi, X Chen, H Zhang, ... The Journal of clinical investigation 122 (1), 280-290, 2012 | 205 | 2012 |
Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy JQ Kwong, J Davis, CP Baines, MA Sargent, J Karch, X Wang, T Huang, ... Cell Death & Differentiation 21 (8), 1209-1217, 2014 | 191 | 2014 |
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Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy SA Parsons, DP Millay, MA Sargent, EM McNally, JD Molkentin The American journal of pathology 168 (6), 1975-1985, 2006 | 128 | 2006 |