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William Brad Ruzicka
William Brad Ruzicka
Assistant Professor of Psychiatry, Harvard Medical School
Verified email at mclean.harvard.edu
Title
Cited by
Cited by
Year
An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability
L Tremolizzo, G Carboni, WB Ruzicka, CP Mitchell, I Sugaya, P Tueting, ...
Proceedings of the National Academy of Sciences 99 (26), 17095-17100, 2002
4702002
Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection
WB Ruzicka, A Zhubi, M Veldic, DR Grayson, E Costa, A Guidotti
Molecular psychiatry 12 (4), 385-397, 2007
2062007
S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis
A Guidotti, W Ruzicka, DR Grayson, M Veldic, G Pinna, JM Davis, E Costa
Neuroreport 18 (1), 57-60, 2007
1242007
Circuit-and diagnosis-specific DNA methylation changes at γ-aminobutyric acid–related genes in postmortem human hippocampus in schizophrenia and bipolar disorder
WB Ruzicka, S Subburaju, FM Benes
JAMA psychiatry 72 (6), 541-551, 2015
1092015
DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients
E Dong, WB Ruzicka, DR Grayson, A Guidotti
Schizophrenia research 167 (1-3), 35-41, 2015
1072015
Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability
E Dong, DR Grayson, A Guidotti, W Ruzicka, M Veldic, E Costa
Epigenetics 2 (1), 29-36, 2007
1062007
GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability
E Costa, Y Chen, E Dong, DR Grayson, M Kundakovic, E Maloku, ...
Expert Review of Neurotherapeutics 9 (1), 87-98, 2009
792009
Fifty years of research on schizophrenia: the ascendance of the glutamatergic synapse
JT Coyle, WB Ruzicka, DT Balu
American Journal of Psychiatry 177 (12), 1119-1128, 2020
642020
Single-cell dissection of schizophrenia reveals neurodevelopmental-synaptic axis and transcriptional resilience
WB Ruzicka, S Mohammadi, J Davila-Velderrain, S Subburaju, DR Tso, ...
MedRxiv, 2020.11. 06.20225342, 2020
622020
Single-cell multi-cohort dissection of the schizophrenia transcriptome
WB Ruzicka, S Mohammadi, JF Fullard, J Davila-Velderrain, S Subburaju, ...
Science 384 (6698), eadg5136, 2024
452024
Epigenetic targets in GABAergic neurons to treat schizophrenia
E Costa, E Dong, DR Grayson, WB Ruzicka, MV Simonini, M Veldic, ...
Advances in pharmacology 54, 95-117, 2006
412006
Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants
JC McAfee, S Lee, J Lee, JL Bell, O Krupa, J Davis, K Insigne, ML Bond, ...
Cell Genomics 3 (10), 2023
252023
Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model
S Subburaju, AJ Coleman, WB Ruzicka, FM Benes
Translational Psychiatry 6 (1), e723-e723, 2016
202016
Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer’s disease
J Davila-Velderrain, H Mathys, S Mohammadi, B Ruzicka, X Jiang, A Ng, ...
bioRxiv, 2021.07. 01.450715, 2021
152021
Epigenetic mechanisms in the pathophysiology of psychotic disorders
WB Ruzicka
Harvard review of psychiatry 23 (3), 212-222, 2015
142015
Variability of DNA methylation within schizophrenia risk loci across subregions of human hippocampus
WB Ruzicka, S Subburaju, FM Benes
Genes 8 (5), 143, 2017
122017
Location matters: distinct DNA methylation patterns in GABAergic interneuronal populations from separate microcircuits within the human hippocampus
WB Ruzicka, S Subburaju, JT Coyle, FM Benes
Human Molecular Genetics 27 (2), 254-265, 2018
72018
Epigenetic regulation of glutamic acid decarboxylase 67 in a hippocampal circuit
S Subburaju, AJ Coleman, MG Cunningham, WB Ruzicka, FM Benes
Cerebral Cortex 27 (11), 5284-5293, 2017
72017
The single-cell opioid responses in the context of HIV (SCORCH) consortium
SA Ament, RR Campbell, MK Lobo, JP Receveur, K Agrawal, A Borjabad, ...
Molecular Psychiatry, 1-12, 2024
32024
643. Sustained Improvement in Mood after 3 Days of Low Field Magnetic Stimulation in Subjects with Bipolar Depression
M Rohan, R Yamamoto, W Ruzicka, M Copersino, S Fuller, M Murphy, ...
Biological Psychiatry 81 (10), S260-S261, 2017
12017
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