| Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation G Canettieri, L Di Marcotullio, A Greco, S Coni, L Antonucci, P Infante, ... Nature cell biology 12 (2), 132-142, 2010 | 391 | 2010 |
| Hedgehog controls neural stem cells through p53‐independent regulation of Nanog A Po, E Ferretti, E Miele, E De Smaele, A Paganelli, G Canettieri, S Coni, ... The EMBO journal 29 (15), 2646-2658, 2010 | 258 | 2010 |
| Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal L Di Marcotullio, A Greco, D Mazzà, G Canettieri, L Pietrosanti, P Infante, ... Oncogene 30 (1), 65-76, 2011 | 144 | 2011 |
| Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma A Po, M Silvano, E Miele, C Capalbo, A Eramo, V Salvati, M Todaro, ... Oncogene 36 (32), 4641-4652, 2017 | 111 | 2017 |
| Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma E De Smaele, L Di Marcotullio, M Moretti, M Pelloni, MA Occhione, ... Neoplasia 13 (4), 374-IN23, 2011 | 102 | 2011 |
| Non-canonical Hedgehog/AMPK-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth D D’Amico, L Antonucci, L Di Magno, S Coni, G Sdruscia, A Macone, ... Developmental cell 35 (1), 21-35, 2015 | 89 | 2015 |
| Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy S Coni, L Antonucci, D D'Amico, L Di Magno, P Infante, E De Smaele, ... PLoS One 8 (6), e65718, 2013 | 81 | 2013 |
| The coactivator CRTC1 promotes cell proliferation and transformation via AP-1 G Canettieri, S Coni, M Della Guardia, V Nocerino, L Antonucci, ... Proceedings of the National Academy of Sciences 106 (5), 1445-1450, 2009 | 81 | 2009 |
| Digging a hole under Hedgehog: downstream inhibition as an emerging anticancer strategy L Di Magno, S Coni, L Di Marcotullio, G Canettieri Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1856 (1), 62-72, 2015 | 77 | 2015 |
| Control of stem cells and cancer stem cells by Hedgehog signaling: pharmacologic clues from pathway dissection S Coni, P Infante, A Gulino Biochemical pharmacology 85 (5), 623-628, 2013 | 75 | 2013 |
| Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma S Coni, AB Mancuso, L Di Magno, G Sdruscia, S Manni, SM Serrao, ... Scientific reports 7 (1), 44079, 2017 | 69 | 2017 |
| Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis P Infante, R Faedda, F Bernardi, F Bufalieri, L Lospinoso Severini, ... Nature communications 9 (1), 976, 2018 | 65 | 2018 |
| Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation S Coni, SM Serrao, ZN Yurtsever, L Di Magno, R Bordone, C Bertani, ... Cell death & disease 11 (12), 1045, 2020 | 64 | 2020 |
| An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma E De Smaele, C Fragomeli, E Ferretti, M Pelloni, A Po, G Canettieri, ... Neoplasia 10 (1), 89-IN36, 2008 | 64 | 2008 |
| Phenformin inhibits hedgehog-dependent tumor growth through a complex I-independent redox/corepressor module L Di Magno, S Manni, F Di Pastena, S Coni, A Macone, S Cairoli, ... Cell reports 30 (6), 1735-1752. e7, 2020 | 59 | 2020 |
| Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth L Di Magno, D Manzi, D D’Amico, S Coni, A Macone, P Infante, ... Cell Cycle 13 (21), 3404-3413, 2014 | 57 | 2014 |
| The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint L Di Magno, A Basile, S Coni, S Manni, G Sdruscia, D D'Amico, ... Oncotarget 7 (8), 9538, 2016 | 51 | 2016 |
| Targeting class I histone deacetylases by the novel small molecule inhibitor 4 SC‐202 blocks oncogenic hedgehog‐GLI signaling and overcomes smoothened inhibitor resistance W Gruber, E Peer, DP Elmer, C Sternberg, S Tesanovic, P Del Burgo, ... International Journal of Cancer 142 (5), 968-975, 2018 | 50 | 2018 |
| The mechanism of action of biguanides: New answers to a complex question L Di Magno, F Di Pastena, R Bordone, S Coni, G Canettieri Cancers 14 (13), 3220, 2022 | 42 | 2022 |
| Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation L Antonucci, L Di Magno, D D’Amico, S Manni, SM Serrao, F Di Pastena, ... International journal of oncology 54 (2), 505-514, 2018 | 33 | 2018 |
