| LRP1 is a master regulator of tau uptake and spread JN Rauch, G Luna, E Guzman, M Audouard, C Challis, YE Sibih, ... Nature 580 (7803), 381-385, 2020 | 477 | 2020 |
| RNA stores tau reversibly in complex coacervates X Zhang, Y Lin, NA Eschmann, H Zhou, JN Rauch, I Hernandez, ... PLoS biology 15 (7), e2002183, 2017 | 293 | 2017 |
| Defining Hsp70 subnetworks in dengue virus replication reveals key vulnerability in flavivirus infection S Taguwa, K Maringer, X Li, D Bernal-Rubio, JN Rauch, JE Gestwicki, ... Cell 163 (5), 1108-1123, 2015 | 278 | 2015 |
| Tau internalization is regulated by 6-O sulfation on heparan sulfate proteoglycans (HSPGs) JN Rauch, JJ Chen, AW Sorum, GM Miller, T Sharf, SK See, ... Scientific reports 8 (1), 6382, 2018 | 200 | 2018 |
| Hsp70–Bag3 interactions regulate cancer-related signaling networks TA Colvin, VL Gabai, J Gong, SK Calderwood, H Li, S Gummuluru, ... Cancer research 74 (17), 4731-4740, 2014 | 185 | 2014 |
| Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro JN Rauch, JE Gestwicki Journal of Biological Chemistry 289 (3), 1402-1414, 2014 | 181 | 2014 |
| Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions Y Lin, J McCarty, JN Rauch, KT Delaney, KS Kosik, GH Fredrickson, ... Elife 8, e42571, 2019 | 155 | 2019 |
| Mapping interactions with the chaperone network reveals factors that protect against tau aggregation SA Mok, C Condello, R Freilich, A Gillies, T Arhar, J Oroz, H Kadavath, ... Nature structural & molecular biology 25 (5), 384-393, 2018 | 155 | 2018 |
| BAG3 is a modular, scaffolding protein that physically links heat shock protein 70 (Hsp70) to the small heat shock proteins JN Rauch, E Tse, R Freilich, SA Mok, LN Makley, DR Southworth, ... Journal of molecular biology 429 (1), 128-141, 2017 | 150 | 2017 |
| Validation of the Hsp70–Bag3 protein–protein interaction as a potential therapeutic target in cancer X Li, T Colvin, JN Rauch, D Acosta-Alvear, M Kampmann, B Dunyak, ... Molecular cancer therapeutics 14 (3), 642-648, 2015 | 143 | 2015 |
| A scalable, easy-to-deploy protocol for Cas13-based detection of SARS-CoV-2 genetic material JN Rauch, E Valois, SC Solley, F Braig, RS Lach, M Audouard, ... Journal of clinical microbiology 59 (4), 10.1128/jcm. 02402-20, 2021 | 139 | 2021 |
| Hsp70 protein complexes as drug targets V A Assimon, A T Gillies, J N Rauch, J E Gestwicki Current pharmaceutical design 19 (3), 404-417, 2013 | 139 | 2013 |
| Cofactors are essential constituents of stable and seeding-active tau fibrils Y Fichou, Y Lin, JN Rauch, M Vigers, Z Zeng, M Srivastava, TJ Keller, ... Proceedings of the National Academy of Sciences 115 (52), 13234-13239, 2018 | 106 | 2018 |
| Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70 Y Miyata, JN Rauch, UK Jinwal, AD Thompson, S Srinivasan, CA Dickey, ... Chemistry & biology 19 (11), 1391-1399, 2012 | 99 | 2012 |
| The proline-rich domain promotes Tau liquid–liquid phase separation in cells X Zhang, M Vigers, J McCarty, JN Rauch, GH Fredrickson, MZ Wilson, ... Journal of Cell Biology 219 (11), e202006054, 2020 | 93 | 2020 |
| A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy I Hernandez, G Luna, JN Rauch, SA Reis, M Giroux, CM Karch, D Boctor, ... Science translational medicine 11 (485), eaat3005, 2019 | 89 | 2019 |
| Stabilizing the Hsp70-Tau complex promotes turnover in models of tauopathy ZT Young, JN Rauch, VA Assimon, UK Jinwal, M Ahn, X Li, BM Dunyak, ... Cell chemical biology 23 (8), 992-1001, 2016 | 84 | 2016 |
| Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks M Meister-Broekema, R Freilich, C Jagadeesan, JN Rauch, ... Nature communications 9 (1), 5342, 2018 | 81 | 2018 |
| Structural and biological interaction of hsc-70 protein with phosphatidylserine in endosomal microautophagy K Morozova, CC Clement, S Kaushik, B Stiller, E Arias, A Ahmad, ... Journal of Biological Chemistry 291 (35), 18096-18106, 2016 | 71 | 2016 |
| Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor B Eftekharzadeh, VC Banduseela, G Chiesa, P Martínez-Cristóbal, ... Nature communications 10 (1), 3562, 2019 | 59 | 2019 |
