| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 A Kobayashi, MI Kang, H Okawa, M Ohtsuji, Y Zenke, T Chiba, K Igarashi, ... Molecular and cellular biology 24 (16), 7130-7139, 2004 | 2540 | 2004 |
| The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 M Komatsu, H Kurokawa, S Waguri, K Taguchi, A Kobayashi, Y Ichimura, ... Nature cell biology 12 (3), 213-223, 2010 | 2513 | 2010 |
| Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice M Komatsu, S Waguri, M Koike, Y Sou, T Ueno, T Hara, N Mizushima, ... Cell 131 (6), 1149-1163, 2007 | 2439 | 2007 |
| Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers N Wakabayashi, AT Dinkova-Kostova, WD Holtzclaw, MI Kang, ... Proceedings of the National Academy of Sciences 101 (7), 2040-2045, 2004 | 1180 | 2004 |
| Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1 A Kobayashi, MI Kang, Y Watai, KI Tong, T Shibata, K Uchida, ... Molecular and cellular biology 26 (1), 221-229, 2006 | 1101 | 2006 |
| Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer B Padmanabhan, KI Tong, T Ohta, Y Nakamura, M Scharlock, M Ohtsuji, ... Molecular cell 21 (5), 689-700, 2006 | 852 | 2006 |
| Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth T Ohta, K Iijima, M Miyamoto, I Nakahara, H Tanaka, M Ohtsuji, T Suzuki, ... Cancer research 68 (5), 1303-1309, 2008 | 738 | 2008 |
| Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription Y Katoh, K Itoh, E Yoshida, M Miyagishi, A Fukamizu, M Yamamoto Genes to Cells 6 (10), 857-868, 2001 | 696 | 2001 |
| Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes MI Kang, A Kobayashi, N Wakabayashi, SG Kim, M Yamamoto Proceedings of the National Academy of Sciences 101 (7), 2046-2051, 2004 | 691 | 2004 |
| Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity T Yamamoto, T Suzuki, A Kobayashi, J Wakabayashi, J Maher, ... Molecular and cellular biology, 2008 | 580 | 2008 |
| Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism KI Tong, A Kobayashi, F Katsuoka, M Yamamoto Walter de Gruyter 387 (10_11), 1311-1320, 2006 | 571 | 2006 |
| Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response KI Tong, B Padmanabhan, A Kobayashi, C Shang, Y Hirotsu, S Yokoyama, ... Molecular and cellular biology 27 (21), 7511-7521, 2007 | 511 | 2007 |
| Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity H Okawa, H Motohashi, A Kobayashi, H Aburatani, TW Kensler, ... Biochemical and biophysical research communications 339 (1), 79-88, 2006 | 479 | 2006 |
| Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P‐4501A1 gene. H Imataka, K Sogawa, KI Yasumoto, Y Kikuchi, K Sasano, A Kobayashi, ... The EMBO journal 11 (10), 3663-3671, 1992 | 447 | 1992 |
| Carnosic acid, a catechol‐type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S‐alkylation of … T Satoh, K Kosaka, K Itoh, A Kobayashi, M Yamamoto, Y Shimojo, ... Journal of neurochemistry 104 (4), 1116-1131, 2008 | 438 | 2008 |
| Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes M Ohtsuji, F Katsuoka, A Kobayashi, H Aburatani, JD Hayes, ... Journal of Biological Chemistry 283 (48), 33554-33562, 2008 | 379 | 2008 |
| Molecular cloning and functional characterization of a new Cap'n'collar family transcription factor Nrf3 A Kobayashi, E Ito, T Toki, K Kogame, S Takahashi, K Igarashi, N Hayashi, ... Journal of Biological Chemistry 274 (10), 6443-6452, 1999 | 377 | 1999 |
| Protein S-guanylation by the biological signal 8-nitroguanosine 3′, 5′-cyclic monophosphate T Sawa, MH Zaki, T Okamoto, T Akuta, Y Tokutomi, S Kim-Mitsuyama, ... Nature chemical biology 3 (11), 727-735, 2007 | 313 | 2007 |
| Unique function of the Nrf2–Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes A Kobayashi, T Ohta, M Yamamoto Methods in enzymology 378, 273-286, 2004 | 304 | 2004 |
| Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome Y Katoh, K Iida, MIL Kang, A Kobayashi, M Mizukami, KI Tong, ... Archives of biochemistry and biophysics 433 (2), 342-350, 2005 | 264 | 2005 |
Masayuki YamamotoTohoku University, ProfessorVerified email at tohoku.ac.jp
