| Recent advances and discoveries in the mechanisms and functions of CAR T cells RC Larson, MV Maus Nature Reviews Cancer 21 (3), 145-161, 2021 | 710 | 2021 |
| CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity BD Choi, X Yu, AP Castano, AA Bouffard, A Schmidts, RC Larson, ... Nature biotechnology 37 (9), 1049-1058, 2019 | 495 | 2019 |
| CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma BD Choi, X Yu, AP Castano, H Darr, DB Henderson, AA Bouffard, ... Journal for immunotherapy of cancer 7, 1-8, 2019 | 289 | 2019 |
| CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours RC Larson, MC Kann, SR Bailey, NJ Haradhvala, PM Llopis, AA Bouffard, ... Nature 604 (7906), 563-570, 2022 | 269 | 2022 |
| Reversible ON-and OFF-switch chimeric antigen receptors controlled by lenalidomide M Jan, I Scarfò, RC Larson, A Walker, A Schmidts, AA Guirguis, JA Gasser, ... Science translational medicine 13 (575), eabb6295, 2021 | 217 | 2021 |
| Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma NJ Haradhvala, MB Leick, K Maurer, SH Gohil, RC Larson, N Yao, ... Nature medicine 28 (9), 1848-1859, 2022 | 152 | 2022 |
| Chimeric antigen receptor costimulation domains modulate human regulatory T cell function AC Boroughs, RC Larson, BD Choi, AA Bouffard, LS Riley, E Schiferle, ... JCI insight 4 (8), 2019 | 127 | 2019 |
| Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma A Schmidts, M Ormhøj, BD Choi, AO Taylor, AA Bouffard, I Scarfò, ... Blood Advances 3 (21), 3248-3260, 2019 | 101 | 2019 |
| Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia MB Leick, H Silva, I Scarfò, R Larson, BD Choi, AA Bouffard, K Gallagher, ... Cancer cell 40 (5), 494-508. e5, 2022 | 95 | 2022 |
| Blockade or deletion of IFNγ reduces macrophage activation without compromising CAR T-cell function in hematologic malignancies SR Bailey, S Vatsa, RC Larson, AA Bouffard, I Scarfò, MC Kann, ... Blood Cancer Discovery 3 (2), 136-153, 2022 | 92 | 2022 |
| Chimeric antigen receptor T cells targeting CD79b show efficacy in lymphoma with or without cotargeting CD19 M Ormhøj, I Scarfò, ML Cabral, SR Bailey, SJ Lorrey, AA Bouffard, ... Clinical Cancer Research 25 (23), 7046-7057, 2019 | 80 | 2019 |
| CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity J Joung, PC Kirchgatterer, A Singh, JH Cho, SP Nety, RC Larson, ... Nature Communications 13 (1), 1606, 2022 | 79 | 2022 |
| A distinct transcriptional program in human CAR T cells bearing the 4-1BB signaling domain revealed by scRNA-seq AC Boroughs, RC Larson, ND Marjanovic, K Gosik, AP Castano, ... Molecular Therapy 28 (12), 2577-2592, 2020 | 78 | 2020 |
| Tandem chimeric antigen receptor (CAR) T cells targeting EGFRvIII and IL-13Rα2 are effective against heterogeneous glioblastoma A Schmidts, AA Srivastava, R Ramapriyan, SR Bailey, AA Bouffard, ... Neuro-Oncology Advances 5 (1), vdac185, 2023 | 35 | 2023 |
| SARS-CoV-2 T-cell immunity to variants of concern following vaccination KME Gallagher, MB Leick, RC Larson, TR Berger, K Katsis, JY Yam, ... BioRxiv, 2021 | 34 | 2021 |
| Four challenges to CAR T cells breaking the glass ceiling SR Bailey, TR Berger, C Graham, RC Larson, MV Maus European Journal of Immunology 53 (11), 2250039, 2023 | 29 | 2023 |
| Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2 BA Trombetta, SE Kandigian, RR Kitchen, K Grauwet, PK Webb, GA Miller, ... BMC infectious diseases 21 (1), 580, 2021 | 27 | 2021 |
| Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources A Schmidts, LC Marsh, AA Srivastava, AA Bouffard, AC Boroughs, I Scarfò, ... Journal for immunotherapy of cancer 8 (2), 2020 | 23 | 2020 |
| Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma M Wehrli, S Guinn, F Birocchi, A Kuo, Y Sun, RC Larson, AJ Almazan, ... Clinical Cancer Research 30 (9), 1859-1877, 2024 | 19 | 2024 |
| Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma RC Larson, MC Kann, C Graham, CW Mount, AP Castano, WH Lee, ... Nature Communications 14 (1), 7509, 2023 | 19 | 2023 |
