| Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions YB Kim, AC Komor, JM Levy, MS Packer, KT Zhao, DR Liu Nature biotechnology 35 (4), 371-376, 2017 | 904 | 2017 |
| Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C: G-to-T: A base editors with higher efficiency and product purity AC Komor, KT Zhao, MS Packer, NM Gaudelli, AL Waterbury, LW Koblan, ... Science advances 3 (8), eaao4774, 2017 | 870 | 2017 |
| Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity MF Richter, KT Zhao, E Eton, A Lapinaite, GA Newby, BW Thuronyi, ... Nature biotechnology 38 (7), 883-891, 2020 | 793 | 2020 |
| Base editing of haematopoietic stem cells rescues sickle cell disease in mice GA Newby, JS Yen, KJ Woodard, T Mayuranathan, CR Lazzarotto, Y Li, ... Nature 595 (7866), 295-302, 2021 | 316 | 2021 |
| Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors TP Huang, KT Zhao, SM Miller, NM Gaudelli, BL Oakes, C Fellmann, ... Nature biotechnology 37 (6), 626-631, 2019 | 278 | 2019 |
| DNA capture by a CRISPR-Cas9–guided adenine base editor A Lapinaite, GJ Knott, CM Palumbo, E Lin-Shiao, MF Richter, KT Zhao, ... Science 369 (6503), 566-571, 2020 | 168 | 2020 |
| Discovery of deaminase functions by structure-based protein clustering J Huang, Q Lin, H Fei, Z He, H Xu, Y Li, K Qu, P Han, Q Gao, B Li, G Liu, ... Cell 186 (15), 3182-3195. e14, 2023 | 114 | 2023 |
| Precise integration of large DNA sequences in plant genomes using PrimeRoot editors C Sun, Y Lei, B Li, Q Gao, Y Li, W Cao, C Yang, H Li, Z Wang, Y Li, ... Nature Biotechnology 42 (2), 316-327, 2024 | 92 | 2024 |
| Base editing rescue of spinal muscular atrophy in cells and in mice M Arbab, Z Matuszek, KM Kray, A Du, GA Newby, AJ Blatnik, A Raguram, ... Science 380 (6642), eadg6518, 2023 | 78 | 2023 |
| Tuning plant phenotypes by precise, graded downregulation of gene expression C Xue, F Qiu, Y Wang, B Li, KT Zhao, K Chen, C Gao Nature Biotechnology 41 (12), 1758-1764, 2023 | 60 | 2023 |
| Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis PC Trippier, KT Zhao, SG Fox, IT Schiefer, R Benmohamed, J Moran, ... ACS chemical neuroscience 5 (9), 823-829, 2014 | 56 | 2014 |
| High efficiency base editors comprising Gam DR Liu, KT Zhao, Y Kim US Patent 11,319,532, 2022 | 33 | 2022 |
| Assigning functionality to cysteines by base editing of cancer dependency genes H Li, T Ma, JR Remsberg, SJ Won, KE DeMeester, E Njomen, ... Nature chemical biology 19 (11), 1320-1330, 2023 | 30 | 2023 |
| An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells YB Kim, KT Zhao, DB Thompson, DR Liu Nature communications 10 (1), 2905, 2019 | 30 | 2019 |
| Strand-preferred base editing of organellar and nuclear genomes using CyDENT J Hu, Y Sun, B Li, Z Liu, Z Wang, Q Gao, M Guo, G Liu, KT Zhao, C Gao Nature Biotechnology 42 (6), 936-945, 2024 | 29 | 2024 |
| Gene editing and agrifood systems C Gao, EM Kikulwe, J Kuzma, M Lema, P Lidder, J Robinson, J Wessler, ... Food and Agriculture Organization of the United Nations, 2022 | 24 | 2022 |
| Tertiary amine pyrazolones and their salts as inhibitors of mutant superoxide dismutase 1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis Y Zhang, KT Zhao, SG Fox, J Kim, DR Kirsch, RJ Ferrante, RI Morimoto, ... Journal of medicinal chemistry 58 (15), 5942-5949, 2015 | 23 | 2015 |
| Prime editing using CRISPR-Cas12a and circular RNAs in human cells R Liang, Z He, KT Zhao, H Zhu, J Hu, G Liu, Q Gao, M Liu, R Zhang, ... Nature biotechnology, 1-9, 2024 | 22 | 2024 |
| T: A TO A: T base editing through adenosine methylation DR Liu, JR Davis, JL Doman, KT Zhao, M Richter US Patent App. 17/436,048, 2022 | 20 | 2022 |
| High efficiency base editors comprising Gam DR Liu, KT Zhao, Y Kim US Patent 11,932,884, 2024 | 13 | 2024 |
David R. LiuHarvard UniversityVerified email at fas.harvard.edu