| Structure of a 16-nm cage designed by using protein oligomers YT Lai, D Cascio, TO Yeates Science 336 (6085), 1129-1129, 2012 | 326 | 2012 |
| Structure of a designed protein cage that self-assembles into a highly porous cube YT Lai, E Reading, GL Hura, KL Tsai, A Laganowsky, FJ Asturias, ... Nature chemistry 6 (12), 1065-1071, 2014 | 314 | 2014 |
| Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 K Xu, P Acharya, R Kong, C Cheng, GY Chuang, K Liu, MK Louder, ... Nature medicine 24 (6), 857-867, 2018 | 301 | 2018 |
| Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli MT Sung, YT Lai, CY Huang, LY Chou, HW Shih, WC Cheng, CH Wong, ... Proceedings of the National Academy of Sciences 106 (22), 8824-8829, 2009 | 203 | 2009 |
| mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron M Gagne, JI Moliva, KE Foulds, SF Andrew, BJ Flynn, AP Werner, ... Cell 185 (9), 1556-1571. e18, 2022 | 174 | 2022 |
| Principles for designing ordered protein assemblies YT Lai, NP King, TO Yeates Trends in cell biology 22 (12), 653-661, 2012 | 169 | 2012 |
| Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529 M Pancera, YT Lai, T Bylund, A Druz, S Narpala, S O'Dell, A Schön, ... Nature chemical biology 13 (10), 1115-1122, 2017 | 143 | 2017 |
| Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV MG Joyce, B Zhang, L Ou, M Chen, GY Chuang, A Druz, WP Kong, YT Lai, ... Nature structural & molecular biology 23 (9), 811-820, 2016 | 143 | 2016 |
| Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly YT Lai, KL Tsai, MR Sawaya, FJ Asturias, TO Yeates Journal of the American Chemical Society 135 (20), 7738-7743, 2013 | 112 | 2013 |
| A universal approach to optimize the folding and stability of prefusion-closed HIV-1 envelope trimers L Rutten, YT Lai, S Blokland, D Truan, IJM Bisschop, NM Strokappe, ... Cell reports 23 (2), 584-595, 2018 | 101 | 2018 |
| Practical approaches to designing novel protein assemblies NP King, YT Lai Current opinion in structural biology 23 (4), 632-638, 2013 | 96 | 2013 |
| Longitudinal analysis reveals early development of three MPER-directed neutralizing antibody lineages from an HIV-1-infected individual SJ Krebs, YD Kwon, CA Schramm, WH Law, G Donofrio, KH Zhou, S Gift, ... Immunity 50 (3), 677-691. e13, 2019 | 92 | 2019 |
| Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice B Ying, SM Scheaffer, B Whitener, CY Liang, O Dmytrenko, S Mackin, ... Cell 185 (9), 1572-1587. e11, 2022 | 82 | 2022 |
| Structure of super-potent antibody CAP256-VRC26. 25 in complex with HIV-1 envelope reveals a combined mode of trimer-apex recognition J Gorman, GY Chuang, YT Lai, CH Shen, JC Boyington, A Druz, H Geng, ... Cell reports 31 (1), 2020 | 66 | 2020 |
| Designing and defining dynamic protein cage nanoassemblies in solution YT Lai, GL Hura, KN Dyer, HYH Tang, JA Tainer, TO Yeates Science advances 2 (12), e1501855, 2016 | 63 | 2016 |
| Solution structure of family 21 carbohydrate-binding module from Rhizopus oryzae glucoamylase YN Liu, YT Lai, WI Chou, MDT Chang, PC Lyu Biochemical Journal 403 (1), 21-30, 2007 | 55 | 2007 |
| Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry YT Lai, T Wang, S O’Dell, MK Louder, A Schön, CSF Cheung, GY Chuang, ... Nature communications 10 (1), 47, 2019 | 50 | 2019 |
| Protection of calves by a prefusion-stabilized bovine RSV F vaccine B Zhang, L Chen, C Silacci, M Thom, JC Boyington, A Druz, MG Joyce, ... npj Vaccines 2 (1), 7, 2017 | 44 | 2017 |
| Automated design by structure-based stabilization and consensus repair to achieve prefusion-closed envelope trimers in a wide variety of HIV strains R Rawi, L Rutten, YT Lai, AS Olia, S Blokland, J Juraszek, CH Shen, ... Cell reports 33 (8), 2020 | 39 | 2020 |
| Mutagenesis study of rice nonspecific lipid transfer protein 2 reveals residues that contribute to structure and ligand binding CS Cheng, MN Chen, YT Lai, T Chen, KF Lin, YJ Liu, PC Lyu Proteins: Structure, Function, and Bioinformatics 70 (3), 695-706, 2008 | 38 | 2008 |
Todd O. YeatesProfessor of Chemistry and Biochemistry, University of California Los Angeles (UCLA)Verified email at mbi.ucla.edu