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Lei Peng
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Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA
S Yuan, L Peng, JJ Park, Y Hu, SC Devarkar, MB Dong, Q Shen, S Wu, ...
Molecular cell 80 (6), 1055-1066. e6, 2020
1852020
In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma
L Ye, JJ Park, MB Dong, Q Yang, RD Chow, L Peng, Y Du, J Guo, X Dai, ...
Nature biotechnology 37 (11), 1302-1313, 2019
1692019
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
L Ye, JJ Park, L Peng, Q Yang, RD Chow, MB Dong, SZ Lam, J Guo, ...
Cell metabolism 34 (4), 595-614. e14, 2022
1262022
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2
Z Fang, L Peng, R Filler, K Suzuki, A McNamara, Q Lin, PA Renauer, ...
Nature communications 13 (1), 3250, 2022
702022
The chemerin receptor CMKLR1 is a functional receptor for amyloid-β peptide
L Peng, Y Yu, J Liu, S Li, H He, N Cheng, RD Ye
Journal of Alzheimer’s Disease 43 (1), 227-242, 2014
672014
TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage
M Magni, G Buscemi, L Maita, L Peng, SY Chan, A Montecucco, D Delia, ...
Cell Death & Differentiation 26 (5), 918-931, 2019
492019
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells
JS Chen, RD Chow, E Song, T Mao, B Israelow, K Kamath, J Bozekowski, ...
Science immunology 7 (68), eabl5652, 2021
392021
Serum amyloid a differentially activates microglia and astrocytes via the PI3K pathway
Y Yu, J Liu, SQ Li, L Peng, RD Ye
Journal of Alzheimer’s disease 38 (1), 133-144, 2013
362013
CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors
L Peng, G Sferruzza, L Yang, L Zhou, S Chen
Cellular & Molecular Immunology 21 (10), 1089-1108, 2024
202024
Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species
L Peng, Z Fang, PA Renauer, A McNamara, JJ Park, Q Lin, X Zhou, ...
Cell Reports 40 (5), 2022
182022
Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2
L Peng, PA Renauer, A Ökten, Z Fang, JJ Park, X Zhou, Q Lin, MB Dong, ...
Cell Reports Medicine 3 (5), 2022
182022
AAV-mediated delivery of a Sleeping Beauty transposon and an mRNA-encoded transposase for the engineering of therapeutic immune cells
L Ye, SZ Lam, L Yang, K Suzuki, Y Zou, Q Lin, Y Zhang, P Clark, L Peng, ...
Nature Biomedical Engineering 8 (2), 132-148, 2024
172024
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B. 1.617
L Peng, Y Hu, MC Mankowski, P Ren, RE Chen, J Wei, M Zhao, T Li, ...
Nature communications 13 (1), 1638, 2022
172022
Double knockout CRISPR screen for cancer resistance to T cell cytotoxicity
JJ Park, A Codina, L Ye, S Lam, J Guo, P Clark, X Zhou, L Peng, S Chen
Journal of Hematology & Oncology 15 (1), 172, 2022
112022
TSPYL2 regulates the expression of EZH2 target genes in neurons
H Liu, L Peng, J So, KH Tsang, CH Chong, PHS Mak, KM Chan, SY Chan
Molecular neurobiology 56, 2640-2652, 2019
112019
Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages
P Ren, Y Hu, L Peng, L Yang, K Suzuki, Z Fang, M Bai, L Zhou, Y Feng, ...
Signal Transduction and Targeted Therapy 8 (1), 281, 2023
92023
In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy
L Peng, PA Renauer, G Sferruzza, L Yang, Y Zou, Z Fang, JJ Park, ...
Nature Biotechnology, 1-10, 2024
62024
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2. Nat. Commun. 13, 3250
Z Fang, L Peng, R Filler, K Suzuki, A McNamara, Q Lin, PA Renauer, ...
62022
RAMIHM generates fully human monoclonal antibodies by rapid mRNA immunization of humanized mice and BCR-seq
P Ren, L Peng, L Yang, K Suzuki, Z Fang, PA Renauer, Q Lin, M Bai, T Li, ...
Cell chemical biology 30 (1), 85-96. e6, 2023
32023
TSPYL1 regulates steroidogenic gene expression and male factor fertility in mice
L Peng, EHW Leung, J So, PHS Mak, CL Lee, H Tan, KF Lee, SY Chan
F&S Science 1 (2), 115-123, 2020
32020
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