Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA S Yuan, L Peng, JJ Park, Y Hu, SC Devarkar, MB Dong, Q Shen, S Wu, ... Molecular cell 80 (6), 1055-1066. e6, 2020 | 185 | 2020 |
In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma L Ye, JJ Park, MB Dong, Q Yang, RD Chow, L Peng, Y Du, J Guo, X Dai, ... Nature biotechnology 37 (11), 1302-1313, 2019 | 169 | 2019 |
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy L Ye, JJ Park, L Peng, Q Yang, RD Chow, MB Dong, SZ Lam, J Guo, ... Cell metabolism 34 (4), 595-614. e14, 2022 | 126 | 2022 |
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2 Z Fang, L Peng, R Filler, K Suzuki, A McNamara, Q Lin, PA Renauer, ... Nature communications 13 (1), 3250, 2022 | 70 | 2022 |
The chemerin receptor CMKLR1 is a functional receptor for amyloid-β peptide L Peng, Y Yu, J Liu, S Li, H He, N Cheng, RD Ye Journal of Alzheimer’s Disease 43 (1), 227-242, 2014 | 67 | 2014 |
TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage M Magni, G Buscemi, L Maita, L Peng, SY Chan, A Montecucco, D Delia, ... Cell Death & Differentiation 26 (5), 918-931, 2019 | 49 | 2019 |
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells JS Chen, RD Chow, E Song, T Mao, B Israelow, K Kamath, J Bozekowski, ... Science immunology 7 (68), eabl5652, 2021 | 39 | 2021 |
Serum amyloid a differentially activates microglia and astrocytes via the PI3K pathway Y Yu, J Liu, SQ Li, L Peng, RD Ye Journal of Alzheimer’s disease 38 (1), 133-144, 2013 | 36 | 2013 |
CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors L Peng, G Sferruzza, L Yang, L Zhou, S Chen Cellular & Molecular Immunology 21 (10), 1089-1108, 2024 | 20 | 2024 |
Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species L Peng, Z Fang, PA Renauer, A McNamara, JJ Park, Q Lin, X Zhou, ... Cell Reports 40 (5), 2022 | 18 | 2022 |
Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 L Peng, PA Renauer, A Ökten, Z Fang, JJ Park, X Zhou, Q Lin, MB Dong, ... Cell Reports Medicine 3 (5), 2022 | 18 | 2022 |
AAV-mediated delivery of a Sleeping Beauty transposon and an mRNA-encoded transposase for the engineering of therapeutic immune cells L Ye, SZ Lam, L Yang, K Suzuki, Y Zou, Q Lin, Y Zhang, P Clark, L Peng, ... Nature Biomedical Engineering 8 (2), 132-148, 2024 | 17 | 2024 |
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B. 1.617 L Peng, Y Hu, MC Mankowski, P Ren, RE Chen, J Wei, M Zhao, T Li, ... Nature communications 13 (1), 1638, 2022 | 17 | 2022 |
Double knockout CRISPR screen for cancer resistance to T cell cytotoxicity JJ Park, A Codina, L Ye, S Lam, J Guo, P Clark, X Zhou, L Peng, S Chen Journal of Hematology & Oncology 15 (1), 172, 2022 | 11 | 2022 |
TSPYL2 regulates the expression of EZH2 target genes in neurons H Liu, L Peng, J So, KH Tsang, CH Chong, PHS Mak, KM Chan, SY Chan Molecular neurobiology 56, 2640-2652, 2019 | 11 | 2019 |
Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages P Ren, Y Hu, L Peng, L Yang, K Suzuki, Z Fang, M Bai, L Zhou, Y Feng, ... Signal Transduction and Targeted Therapy 8 (1), 281, 2023 | 9 | 2023 |
In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy L Peng, PA Renauer, G Sferruzza, L Yang, Y Zou, Z Fang, JJ Park, ... Nature Biotechnology, 1-10, 2024 | 6 | 2024 |
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2. Nat. Commun. 13, 3250 Z Fang, L Peng, R Filler, K Suzuki, A McNamara, Q Lin, PA Renauer, ... | 6 | 2022 |
RAMIHM generates fully human monoclonal antibodies by rapid mRNA immunization of humanized mice and BCR-seq P Ren, L Peng, L Yang, K Suzuki, Z Fang, PA Renauer, Q Lin, M Bai, T Li, ... Cell chemical biology 30 (1), 85-96. e6, 2023 | 3 | 2023 |
TSPYL1 regulates steroidogenic gene expression and male factor fertility in mice L Peng, EHW Leung, J So, PHS Mak, CL Lee, H Tan, KF Lee, SY Chan F&S Science 1 (2), 115-123, 2020 | 3 | 2020 |